The prognostic value of tumor-stroma proportion in laryngeal squamous cell carcinoma

Abstract

This is the first series investigating tumor-stroma proportion as a prognostic marker in laryngeal carcinomas proposing a new method, but the findings do not support tumor-stroma proportion as a prognostic marker.

Scoring the tumor-stroma ratio in colon cancer: procedure and recommendations

“…Most studies have validated our findings of the prognostic impact of the TSR in various kinds of malignant epithelial tumors. However, three studies have not been able to demonstrate validation of the TSR [ 22 , 26 , 27 ]. Discrepancies were caused by a different interpretation of the TSR scoring method.…”

“…Discrepancies were caused by a different interpretation of the TSR scoring method. Instead of using the highest stroma percentage, these studies used either the mean percentage in case of heterogeneity [ 26 ], only one area of 9 mm 2 at the tumor leading or non-leading edge [ 22 ], or the mean percentage of five image fields from not only the deepest invasive margin but also adjacent tumor areas [ 27 ]. The latter two studies both used semi-automated image analysis.…”

Correlation of Carcinoma Percentage (CP) in Colorectal Adenocarcinoma with Several Clinical Pathological Aspects in Anatomical Pathology Department Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital Jakarta in Year 2012-2013

“…has better prognosis. 7,11,12 Similar methods was also used by Courrech Stall et al to determine CP in oesophageal adenocarcinoma and CP evaluation in breast tumour by Moorman et al 11,12,14 In this retrospective study, the number of colorectal carcinoma tend to be relatively more common in male compared to female. 58 cases (63.05%) were found in male patients with 36 cases (39.13%) of CP-Low and 22 cases (23.92%) of CP-High.…”

“…Myofibroblast was a component from desmoplastic stroma which has important role in tumour development process, invasion process, metastasis process or even as a prognostic indicator in primary tumour. 14,15 Myofibroblast which is close to the nest of tumour cells may express α-smooth muscle actin (α-SMA)-positive myofibroblast though secretion of metalloproteinase (MMP), cytokines, chemokines, and neoplastic cells, which can produce lytic enzymes to degrade basal membrane and membrane around the tumour gland. One of the important mediators is transforming growth factor (TGF-β).…”

The Tumor Microenvironment in Liver Metastases from Colorectal Carcinoma in the Context of the Histologic Growth Patterns

“…Moreover, in different types of cancer, the quantity of CAFs is associated with bad prognosis [42][43][44]. However, the existence of different CAF subpopulations associated with different functions has been demonstrated [45,46].…”