The Progress of Diallyl Disulfide in Anti-Cancer

Lz, Xia; Liao, Qianjin; Wang, H; Nie, Song; Q, Liu; Oyang, Linda; X, Chen; Tan, Shuhua; Yo, Tian; Su, Meirong; Lin, Kun-You; J, Xia Luo; Zhou, Yujuan

doi:10.4172/2167-7700.1000246

Cited by 61 publications

(77 citation statements)

References 112 publications

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“…Furthermore, the nutrient uptake at harvest i.e., N, P, and K under the well-watered condition increased by 38-53% (Figure 6A), 31-50% (Figure 6B), and 33-51% (Figure 6C), respectively among the genotypes. The greater uptake could be associated with the improved root system and enhanced the above-ground biomass production, as the soil water status influences the uptake, translocation, and assimilation of nutrients (particularly N in wheat) (Li et al, 2009;Shi et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Above and below-ground growth, accumulated dry matter and nitrogen remobilization of wheat (Triticum aestivum) genotypes grown in PVC tubes under well- and deficit-watered conditions

et al. 2023

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The continuing decline in water resources under the ever-changing climate compels us to re-orient our focus to a more sustainable practice. This study investigates the performance of Triticum aestivum wheat genotypes viz. HD-2967, HD-3086, HD-3249, DBW-187, and HD-3226 under well- and deficit-watered conditions for their root-traits, biomass and nitrogen accumulation and remobilization, and water use efficiencies, grown in PVC-tubes. The genotypes HD-2967, HD-3086, HD-3249, DBW-187, and HD-3226 under well-watered (WW) resulted in 36, 35, 38, 33, and 42% more grain yield compared to deficit-watered (DW). Among the genotypes, HD-3249 had the highest grain yield under both well- and deficit-watered conditions. Compared to DW, the WW had 28%, 30%, and 28% greater root length, biomass, and root length density at flowering {102 days (d), Z61}, while among the genotypes, HD-3249 had relatively greater root-traits. At flowering (Z61) and maturity (132 d, Z89), genotypes under WW accumulated 30-46% and 30-53%, respectively greater shoot biomass over the DW. Furthermore, the shoot biomass remobilised for HD-2967, HD-3086, HD-3249, DBW-187, and HD-3226 under the WW was 32, 37, 39, 35, and 35% greater than the DW. The nitrogen partitioning to different plant parts at flowering (Z61) and maturity (Z89) was significantly greater with the WW than with DW. The total nitrogen- remobilized and contribution to grain-N under the WW was 55, 58, 52, 53, 58% and 9, 19, 15, 17, 17% greater than the DW for the genotypes HD-2967, HD-3086, HD-3249, DBW-187, and HD-3226. The irrigation water use efficiency (WUE) at flowering (Z61) was more under the deficit-watered, but the biomass and grain total WUE was improved with the well-watered condition. Hence, it is apparent that proper scheduling of irrigation and N applications, along with the adoption of a genotype suited to a particular environment, will result in better WUE and grain yields, along with better utilization of scarce resources.

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Section: Discussionmentioning

confidence: 99%

Above and below-ground growth, accumulated dry matter and nitrogen remobilization of wheat (Triticum aestivum) genotypes grown in PVC tubes under well- and deficit-watered conditions

et al. 2023

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“…MEK and IKKα, which activates NFkB signalling, were shown to be downstream targets of LYN in an analysis of the kinomes of imatinib-sensitive and resistant leukaemia cells (Cooper et al, 2013). LYN is required for TLR2-mediated NFkB activation though PI3K signalling in HEK293 cells engineered to express TLR2 (Toubiana et al, 2015) while TLR4mediated NFkB activation in macrophages as a response to LPS treatment is associated with LYN activation and subsequent activation of downstream MAP pathways (Li et al, 2022). Furthermore, Lyn -/mast cells show less MAPK and IkB phosphorylation and less NFkB nuclear translocation after TLR4 triggering than wild type cells (Avila et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Conditionalin vivodeletion of LYN kinase has little effect on aBRCA1loss-of-function-associated mammary tumour model

Tornillo

Warrington

Kendrick

et al. 2023

Preprint

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We have previously demonstrated that the SRC-family kinase LYN is expressed in mammary tumours from a BRCA1 loss-of-function-dependent mouse mammary tumour model, as well as in the cells of origin of such tumours, the mammary luminal epithelial stem/progenitor cells, and in human basal-like/hormone receptor negative breast cancers. We have also shown that suppressing LYN kinase activity in BRCA1-defective cell lines, as well as in in vitro cultures of Brca1-null mouse mammary tumours, is deleterious to their growth. Here, we have examined the interaction between LYN kinase and BRCA1 loss-of-function in an in vivo mouse mammary tumour model, using conditional knockout Brca1 and Lyn alleles. Comparison of tumour cohorts carrying Brca1 conditional alleles on a p53 heterozygous background and also either wild type, heterozygous or homozygous for the conditional Lyn allele, demonstrated that homozygous conditional Lyn cohorts had a small, but significant, decrease in median survival time compared to the other genotypes. However, this was confounded by the development of multiple tumours in some animals, and continued expression of LYN in some Lynfl/fl tumours (as well as low levels of LYN in some Lynwt/wt tumours). We therefore carried out a transcriptomic analysis of Lynwt/wt, Lynfl/wt and Lynfl/fl tumours, identifying differentially expressed genes between tumour groups categorised on the basis of supervised (comparison between tumours with high and low Lyn levels as measured directly by RNAseq) and unsupervised (Principal Component Analysis-based) methods. There was substantial overlap between tumours determined by the supervised and unsupervised approaches, suggesting levels of Lyn expression were, at least in part, responsible for biological differences between the tumours. The analysis also showed that Lyn high tumours had a significantly slower doubling time than Lyn low tumours and were enriched in inflammatory pathways and canonical NfkB signalling. Taken together with our previous findings, these results suggest a context-dependency to LYN signalling in mammary epithelial tumour cells, similar to its biology in B-cells.

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“…However, at a constant pollutant concentration, the excess catalyst will reduce the pollutant concentration and ozone content per unit area due to the saturation of the ozone and internal active sites of the catalyst, and the newly added active sites cannot be effectively utilized, thus reducing the catalyst efficiency. 95 Hence, it is essential to improve the amount of catalyst according to the study results to achieve a better degradation effect.…”

Section: Catalyst Dosagementioning

confidence: 99%

Research Progress of Iron-Based Catalysts in Ozonation Wastewater Treatment

Zou

et al. 2023

ACS EST Water

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On account of the rich contents of iron-based catalysts, low preparation costs, and good effects, they play important roles in various fields of water treatment. There are many kinds of iron oxides, which have been employed in catalytic ozone oxidation processes. However, a thorough analysis of their syntheses, characterization techniques, reactions affecting variables, and mechanistic applications is lacking in the catalytic ozone oxidation sector. It is necessary to search for the catalytic efficiencies of different types of iron-based catalysts in the ozone system and elucidate the activation mechanisms of hydroxyl radicals by iron-based catalysts. In this paper, the synthesis methods, characterization techniques, and practical application fields are summarized in detail. The catalytic performances of iron-based catalysts in the ozone system are explored. The effects of solution pH, reaction temperature, catalyst addition amount, ozone concentration, and inorganic anions on the degradations of organic pollutants and the stability of an iron-based catalyst/oxidant system are also discussed. The activation mechanisms of free radicals and the removal mechanisms of organic pollutants in the iron-based catalyst/ozone system are revealed by a detection method, characterization technology, and theoretical analysis. The potential preparation methods, practical applications, auxiliary technologies, and influences on ozone catalysis are prospected.

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The Progress of Diallyl Disulfide in Anti-Cancer

Cited by 61 publications

References 112 publications

Above and below-ground growth, accumulated dry matter and nitrogen remobilization of wheat (Triticum aestivum) genotypes grown in PVC tubes under well- and deficit-watered conditions

Above and below-ground growth, accumulated dry matter and nitrogen remobilization of wheat (Triticum aestivum) genotypes grown in PVC tubes under well- and deficit-watered conditions

Conditionalin vivodeletion of LYN kinase has little effect on aBRCA1loss-of-function-associated mammary tumour model

Research Progress of Iron-Based Catalysts in Ozonation Wastewater Treatment

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