The progression of BMI status over time in Irish ambulant children with cerebral palsy

Brady, Karen; Kiernan, Damien; Marron, A.

doi:10.1007/s11845-021-02635-x

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Children with cerebral palsy are not immune to the devastating impact of this disease, as the prevalence of obesity in ambulatory individuals with cerebral palsy was shown to increase from a rate of 7.7% in the years 1994-1997 to 16.5% in 2003-2004, based on retrospective electronic health record data including age, gender, weight, height, and cerebral palsy classification. 15 Moreover, it has been suggested that the risk of obesity and overweight body classification is greater in children suffering from chronic disease or disability. 16 There are several reasons why children with cerebral palsy may be at increased risk for obesity.…”

Section: Discussionmentioning

confidence: 99%

Odds of Cardiometabolic Diseases and Medications in Children With Cerebral Palsy

et al. 2023

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Introduction/Objectives Individuals with cerebral palsy may be at risk of obesity, but outcomes and risk factors are understudied. The study objectives are to evaluate the frequency of body mass index (BMI) weight categories of individuals with cerebral palsy and the odds of cardiometabolic-specific diseases and medications. We hypothesize subjects with cerebral palsy and an increased body mass index will have higher odds of cardiometabolic specific diseases and medications. Methods This is a retrospective observational cohort study utilizing TriNetX, an electronic health record database, in subjects with cerebral palsy aged 2-18 years with an available body mass index. The study population was divided into 4 body mass index percentile categories, underweight (<5th body mass index percentile), healthy weight (≥5th to <85th percentile), overweight (≥85th to <95th percentile), and obese (≥95th percentile), and the odds of the following variables were evaluated: diagnostic codes and medication codes. We computed the odds ratio to test for associations between the body mass index categories and the variables of interest. Results A total of 5993 subjects were included: underweight (251, 4.2%), healthy weight (2390, 39.9%), overweight (943, 15.7%), and obese (2409, 40.2%). Obese subjects had a higher odds of asthma, diabetes mellitus, hypertension, and sleep apnea when compared to the health weight group. Conclusions This study found patients with cerebral palsy classified as obese had higher odds of cardiometabolic comorbidity and medication codes that influence weight. Body mass index measurements are limited in this population but may be used cautiously to evaluate the body type of children with cerebral palsy and monitor cardiometabolic-associated comorbidity occurrence.

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Section: Discussionmentioning

confidence: 99%

Odds of Cardiometabolic Diseases and Medications in Children With Cerebral Palsy

et al. 2023

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“…Children with CP are not immune to the devastating impact of this disease, as the prevalence of obesity in ambulatory individuals with CP was shown to increase from a rate of 7.7% from the years 1994-1997 to 16.5% from 2003-2004, based on retrospective EHR data including age, gender, weight, height, and cerebral palsy classi cation. [15] Moreover, it has been suggested that the risk of obesity and overweight body classi cation is greater in children suffering from chronic disease or disability. [15] There are several reasons why children with CP may be at increased risk for obesity.…”

Section: Discussionmentioning

confidence: 99%

“…[15] Moreover, it has been suggested that the risk of obesity and overweight body classi cation is greater in children suffering from chronic disease or disability. [15] There are several reasons why children with CP may be at increased risk for obesity. Both being small for gestational age and prematurity are known to be risk factors for obesity later in life, likely secondary to changes in insulin sensitivity and disruptions of the growth hormone-insulin-like growth factor axis, [16] and intrauterine growth restriction, [17] respectively.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Cardiometabolic Diseases and Medications in Children with Cerebral Palsy

Dum

Walter

Thomas

et al. 2022

Preprint

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Introduction/Objectives: Cerebral palsy (CP) patients may be at risk of obesity, but outcomes and risk factors are understudied. The objectives of this study are to evaluate the body mass index (BMI) types of CP patients and to evaluate the presence of cardiometabolic specific diseases and medications. We hypothesize CP subjects with an increased BMI have a higher frequency of cardiometabolic specific diseases and medications. Methods: This is a retrospective observational cohort study utilizing TriNetX ®, an electronic health record (EHR) database, in CP subjects aged 2 to 18 years who had a BMI value available. The study population was divided into 4 BMI percentile groups, underweight (<5th BMI percentile), healthy weight (≥5th to <85th percentile), overweight (≥85th to <95th percentile), and obese (≥95th percentile), and the following variables were evaluated: demographics, diagnostic codes, and medication codes. Results: A total of 5993 subjects were included [underweight (251, 4.2%), healthy weight (2390, 39.9%), overweight (943, 15.7%), and obese (2409, 40.2%)]. Obese subjects had a higher frequency of the following: asthma [811 (33.7%), p=0.0001], diabetes mellitus [102 (4.2%), p=0.0001], hypertension [213 (8.8%), p=0.0001], and sleep apnea [686 (28.5%), p=0.0001]. Overweight subjects had a higher frequency of spastic diplegic cerebral palsy [574 (60.9%), p=0.0001). Conclusions: This study found CP patients classified as obese had a higher frequency of cardiometabolic comorbidity and medication codes that influence weight. BMI measurements are limited in this population but may be used cautiously to evaluate the body type of CP children, and monitor the occurrence of cardiometabolic associated comorbidities.

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The impact of BMI progression on gait kinematics in children with cerebral palsy

Brady

Kiernan²

2022

Gait & Posture

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The progression of BMI status over time in Irish ambulant children with cerebral palsy

Cited by 3 publications

References 21 publications

Odds of Cardiometabolic Diseases and Medications in Children With Cerebral Palsy

Odds of Cardiometabolic Diseases and Medications in Children With Cerebral Palsy

Frequency of Cardiometabolic Diseases and Medications in Children with Cerebral Palsy

The impact of BMI progression on gait kinematics in children with cerebral palsy

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