The projected public health and economic impact of vitamin D fortified dairy products for fracture prevention in France

Hiligsmann, Mickaël; Reginster, Jean‐Yves

doi:10.1080/14737167.2017.1375406

Cited by 8 publications

(14 citation statements)

References 15 publications

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“…With reference to vitamin D food fortification, there are only a few reports available on its cost-effectiveness. The available studies have reported that systematic vitamin D fortification may indeed be highly cost-effective [102]. The following distribution of costs for a typical food fortification programme was determined as follows: 80% recurrent production costs, 8% marketing and education costs, 7% food control and monitoring costs, and 5% other production costs [103].…”

Section: Vitamin D Fortification Strategiesmentioning

confidence: 99%

Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis

et al. 2020

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Background: Vitamin D and calcium are important dietary compounds that affect bone mass, even if other minerals (potassium, zinc, etc.) and vitamins (A, C and K) are also involved. Vitamin D and certain minerals, in fact, play an important role in calcium homeostasis and calcium absorption. Hip fracture incidence is higher in Europe and the United States, where calcium is frequently included in the human diet; while the occurrence of these fractures is lower in developing countries, where diets are often poor in calcium. This condition is named the “calcium paradox”, and may be partially explained by phosphate toxicity, which can negatively affect mineral metabolism. It is important to maintain correct dietary calcium-phosphate balance in order to have a healthy life, reducing the risk of osteoporotic fractures in older people. Vitamin D can also act as a hormone; vitamin D2 (ergocalciferol) is derived from the UV-B radiation of ergosterol, the natural vitamin D precursor detected in plants, fungi, and invertebrates. Vitamin D3 (cholecalciferol) is synthesized by sunlight exposure from 7-dehydrocholesterol, a precursor of cholesterol that can also act as provitamin D3. Dietary intake of vitamin D3 is essential when the skin is exposed for short periods to ultraviolet B light (UV-B), a category of invisible light rays such as UV-A and UV-C. This can be considered the usual situation in northern latitudes during the winter season, or the typical lifestyle for older people and/or for people with very white delicate skin. The actual recommended daily intake of dietary vitamin D is strictly correlated with age, ranging from 5 μg for infants, children, teenagers, and adults—including pregnant and lactating women—to 15 μg for people over 65 years.

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Section: Vitamin D Fortification Strategiesmentioning

confidence: 99%

Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis

et al. 2020

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“…Previous scenario analyses have modeled changes in healthcare costs from beneficial shifts in dietary patterns and provide an indication of the potentially substantial economic impact associated with modifications to the population's diet [7][8][9][10][11]. The purpose of this study is to estimate the impact on healthcare costs associated with a reduced incidence of total CVD based on modeling incremental increases in whole grains consumption as a proportion of total grains up to levels recommended in the DGA.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Healthcare Cost Savings Associated with Increased Whole Grains Consumption among Adults in the United States

Murphy

Schmier

2020

Nutrients

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Little is known about the potential health economic impact of increasing the proportion of total grains consumed as whole grains to align with Dietary Guidelines for Americans (DGA) recommendations. Health economic analysis estimating difference in costs developed using (1) relative risk (RR) estimates between whole grains consumption and outcomes of cardiovascular disease (CVD) and a selected component (coronary heart disease, CHD); (2) estimates of total and whole grains consumption among US adults; and (3) annual direct and indirect medical costs associated with CVD. Using reported RR estimates and assuming a linear relationship, risk reductions per serving of whole grains were calculated and cost savings were estimated from proportional reductions by health outcome. With a 4% reduction in CVD incidence per serving and a daily increase of 2.24 oz-eq of whole grains, one-year direct medical cost savings were estimated at US$21.9 billion (B) (range, US$5.5B to US$38.4B). With this same increase in whole grains and a 5% reduction in CHD incidence per serving, one-year direct medical cost savings were estimated at US$14.0B (US$8.4B to US$22.4B). A modest increase in whole grains of 0.25 oz-eq per day was associated with one-year CVD-related savings of $2.4B (US$0.6B to US$4.3B) and CHD-related savings of US$1.6B (US$0.9B to US$2.5B). Increasing whole grains consumption among US adults to align more closely with DGA recommendations has the potential for substantial healthcare cost savings.

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“…This new policy would require formal Government approval and careful modelling of the current level of vitamin D intake taking into account voluntary fortification and self-supplementation. However, it could have significant benefits in terms of bone and musculoskeletal health (economically and socially) [43][44][45] in addition to the suggested immune health benefits. Moreover this is particularly timely given current lock-down arrangements and government advice e.g.…”

Section: Discussionmentioning

confidence: 99%

COVID-19: the heart and other issues

2020

Br J Cardiol

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BackgroundVitamin D is a micronutrient which is essential to help maintain bone and musculoskeletal health 1 . However, recent research has highlighted a crucial supportive role for vitamin D in immune cell function, particularly in modulating the inflammatory response to viral infection 2,3 . At a cellular level, vitamin D modulates both the adaptive and innate immune system through cytokines and regulation of cell signalling pathways 4 . Vitamin D receptor (VDR) is present on both T and B immune cells; Vitamin D modulates the proliferation, inhibition and differentiation of these cells 5 . In experimental models of lipopolysaccharide-induced inflammation, vitamin D is associated with lower concentrations of the pro-inflammatory cytokine Interleukin-6 (IL-6) 6 , which plays a significant role in Covid-19 induced acute respiratory distress syndrome (ARDS) 7 . Vitamin D also reduces lipolysaccharide-induced lung injury in mice by blocking

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The projected public health and economic impact of vitamin D fortified dairy products for fracture prevention in France

Cited by 8 publications

References 15 publications

Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis

Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis

Cardiovascular Healthcare Cost Savings Associated with Increased Whole Grains Consumption among Adults in the United States

COVID-19: the heart and other issues

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