The Prolongation of Renal Allograft Survival by an Immunosuppressive Peptide Isolated From Human Plasma

Menzoı́an, James O.; Glasgow, Arthur H.; Nimberg, Richard B.; Constantian, Mark B.; Stevens, Richard L; Cooperband, Sidney R.; Schmid, Karl; Mannick, John A.

doi:10.1097/00007890-197411000-00002

Cited by 5 publications

(1 citation statement)

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“…Occino et al 6) demonstrated a polypeptide that is present in human serum, and its molecular weight is below 10,000 dalton. Menzoian et al 7 , 8) suggested that the polypeptide suppresses many immunologic reactions which are mediated by T lymphocyte. Also, Viet and Mechael demonstrated an inhibitor of immunologic response increased whenever the immune system was stimulated.…”

Section: Introductionmentioning

confidence: 99%

Effect of β-endorphin and Cortisol on the PHA Stimulated Lymphoblastogenesis

Yang

Yoon

Cho

et al. 1986

Korean J Intern Med

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The mechanism of immune suppression in a severely stressful condition is not known. Since the demonstration of β-endorphin receptor on the surface of the circulating lymphocyte, it was reported that β-endorphin could suppress PHA stimulated lymphoblastogenesis. Because the concentration of β-endorphin was supraphysiologically high, it is doubtful that β-endorphin can suppress the lymphoblastogenesis directly in vivo. We investigated the suppression of PHA stimulated lymphoblastogenesis by β-endorphin in vitro and the effect of β-endorphin in some conditions where β-endorphin increases in vivo.PHA induced lymphoblastogenesis of T lymphocyte was maximal at the concentration of 5 μg/ml. β-endorphin could not suppress the blastogenesis even at the highest concentration. In the five healthy men who received metyrapone the previous night, PHA stimulated blastogeneses were not significantly suppressed. In a patient with Nelson’s syndrome, the lymphoblastogenesis was suppressed at all concentrations of PHA.Cortisol significant suppressed the blastogenesis even at the concentration of 10 μg/dl and its suppressive effect was shown in dose dependant manner.Our results suggested that β-endorphin could not suppress the lymphoblastogenesis directly in vivo.

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Section: Introductionmentioning

confidence: 99%

Effect of β-endorphin and Cortisol on the PHA Stimulated Lymphoblastogenesis

Yang

Yoon

Cho

et al. 1986

Korean J Intern Med

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Serum-mediated immunosuppression in lung cancer

Giuliano

Rangel

Golub

et al. 1979

Cancer

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Immunosuppression in 45 patients with lung cancer was studied by examining delayed cutaneous hypersensitivity reactions to DNCB and by analyzing the effect of the patient's serum on the proliferative response of normal donor lymphocytes. Both diminution of DNCB reactivity and inhibition of the pro-liferative response of normal donor lymphocytes to mitogens were associated with the stage of the disease and the presence of unresected tumor. Suppres-sive sera were associated with poor prognosis. The suppressive effects of patients' sera on lymphocytes from a normal donor suggest that the immuno-suppression seen in lung cancer may be mediated by serum factors. The significant association of clinically evident tumor with this serum-mediated im-munosuppression further suggests that the tumor itself could account for the appearance of these factors in the host. The clinical implications of these findings may be useful for designing new clinical trials. Cancer 43:917-924, 1979.

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