The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene

Application of Fullerenes in Nanomedicine: An Update

“…This ability to scavenge free radicals has led to their potential as a new way for treating a wide range of diseases and pathologies; these include multiple sclerosis (MS) [7] , neurodegenerative [8] , anti-HIV activity [9,10] , cancer [11] , radiation exposure [12] , ischemia [13] , osteoporosis [14] , general inflammation [15] and selective antimicrobial agents against bacteria [16] . Interestingly, mice and rats chronically treated with water-solubilized carboxylated fullerenes have significantly extended lifespans compared with littermate controls [17,18] . There are almost endless possibilities for adding side groups to the carbon cage to induce functionality, resulting in potential answers to some of modern medicine's most elusive problems.…”

“…Even more recently these original studies were formally addressed by a follow-up publication, which stated that the original Oberdorster study was 'compromised by experimental artifacts' [94] . On the opposite end of the spectrum, studies in mice demonstrate that similar C 60 preparations significantly increase the lifespan of mice [17] and rats [18] . Thus, it is difficult for researchers, and the general public, to determine if fullerenes are dangerous nanostructures that should be banned or a potential novel platform for developing new medicines.…”

“…Furthermore, several experimental studies revealed that mice treated with excessive dosages (2000 mg/kg) of fullerenes have shown no overt toxicity [96,97] . In fact, some studies have shown that fullerene treatment in mice and rats can improve cognitive function and extend lifespan by 11% (in the mouse model) and 90% (in the rat model) [17,18] . Clearly contrasting results and limited longterm data need to be addressed and efforts on creating reliable, reproducible results are still required for successful translation of these molecules into human systems.…”

Fullerenes: Characteristics of the substance, biological effects and occupational exposure levels

“…Maksymalne stężenie fulerenu we krwi (0,52±0,16 µg/ml) odnotowano po 8 godz., a półokres wydalania wyniósł 12,6±0,9 godz. [20].…”

“…[20]) podawali szczurom przez zgłębnik roztwór fulerenu w oliwie z oliwek w dawce 4 mg/kg m.c./dzień przez 7 dni. Narzą-dy do badań (wątroba, śledziona i mózg) pobierano w 1. i 8. dniu trwania eksperymentu.…”