The prolonged treatment of castrated and ovariectomized rats with testosterone propionate

Abstract

MIESCHER et at. [1936, 1, 2] found that the activity of testosterone on male sexual organs was greatly increased by esterification. Of the various esters prepared the propionate, as judged by short-duration experiments, proved to be the most effective. It brought about a greater increase in the size of the male sexual organs in castrated rats and also a longer duration of the effect than was obtained with other esters; e.g. after a single injection of 2 mg. of testosterone propionate, dissolved in 2 ml. of sesame oil, or after two injections of 1 mg. in 1 ml. of sesame oil with a 5-day interval, the maximum effect was obtained on about the 11th day after the first injection, the activity lasting at least 2-4 weeks. With testosterone the activity had disappeared by the 11th day, the maximum effect being observed a few days after the injection. Parkes [1936] also confirmed the results quoted above in short-duration experiments on the prostate and seminal vesicles. Such properties of the propionate would be important from a therapeutic viewpoint and it is also possible that testosterone is normally present in the body as an ester. On the basis of the experiments with the esters of testosterone Miescher et al. [1936, 2] confirmed the conclusion which we have repeatedly emphasized in our

The Influence of Sex Hormones on the Weight of the Adrenal Gland in the Rat

“…(1) The female Effect of androgen The finding that TP causes a decrease in the weight of the adrenal glands of female rats is in agreement with the reports of many workers, who have carried out experiments with various androgens [Korenchevsky, Dennison & Eldridge, 1937;Wolfe & Hamilton, 1939;Korenchevsky, Hall & Burbank, 1939;Mazer & Mazer, 1939;Selye, 1940;Schilling & Laqueur, 1942]. …”

“…This effect of androgen has frequently been demonstrated [Hall & Korenchevsky, 1938;Korenchevsky et al 1937; Koren¬ chevsky, Hall & Ross, 1939;Greep & Chester Jones, 1950].…”

Histoire des traitements antipsychotiques à action prolongée dans la schizophrénie

“…Cette approche avait été initiée à partir des années 1930 chez l'animal et largement déve-loppée chez l'homme dans les années 1950. La testostérone était ainsi injectée sous forme estérifiée avec du propionate [17] ou de l'énanthate [18]. On trouve à partir de 1961 les premières utilisations du mot depot en langue anglaise pour désigner des préparations hormonales injectables à libéra-tion prolongée, avant que ce même terme soit utilisé en anglais pour les NAP.…”

Some effects of compounds of the androsterone‐testosterone series on ovariectomized mice

“…None of these has been found to be entirely without gynsecogenic effects. Injection of all but androsterone causes appreciable increase in the weight of the uterus and vagina of the ovariectomized rat [Korenchevsky & Dennison, 1935Korenchevsky et al 1937] and stimulates the vagina of the immature female rat to open precociously [Deanesly & Parkes, 1936a]. Testosterone, androstenedione, transdehydroandrosterone and trans-androstenediol stimulate the growth of the immature rabbit uterus [Deanesly & Parkes, 1937], the others listed above not having been investigated.…”

“…Testosterone, androstenedione, transdehydroandrosterone and trans-androstenediol stimulate the growth of the immature rabbit uterus [Deanesly & Parkes, 1937], the others listed above not having been investigated. The same four substances are able to feminize the plumage of the Sebright bantam in doses of 1 mg. daily, but androsterone in large doses [Callow & Parkes, 1936] [Korenchevsky & Dennison, 1936b;Korenchevsky & Hall, 1937]. Hypertrophy of the female preputial glands in the rat has accompanied the gynsecogenic action of all the androgens [Korenchevsky et al 1935-7].…”