The prominence of smoking‐related mortality among individuals with alcohol‐ or drug‐use disorders

Callaghan, Russell C.; Gatley, Jodi M.; Sykes, Jenna; Taylor, Lawren

doi:10.1111/dar.12475

Cited by 27 publications

(20 citation statements)

References 43 publications

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“…Individuals in SUD treatment are more likely to die from tobacco-related diseases compared to the general population (Bandiera et al, 2015;Hurt et al, 1996). For example, (Callaghan et al, 2018) extracted discharge records for all patients hospitalized in California (1990California ( -2005 and matched them to death records. They found that among hospital discharges reporting drug or alcohol use disorders, 36-49% of all deaths were attributable to smoking-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Smoking related outcomes before and after implementation of tobacco-free grounds in residential substance use disorder treatment programs

Gubner

Williams

et al. 2019

Drug and Alcohol Dependence

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Background: This study examined the impact of a tobacco-free grounds (TFG) policy and the California $2.00/pack tobacco tax increase on tobacco use among individuals in residential substance use disorder (SUD) treatment. Methods: We conducted three cross-sectional surveys of clients enrolled in three residential SUD treatment programs. Wave 1 (Pre-TFG) included 190 clients, wave 2 (post-TFG and pre-tax increase) included 200 clients, and wave 3 (post-tax increase) included 201 clients. Demographic and tobacco-use characteristics were first compared between waves using bivariate comparisons. Regression models were used to compare each outcome with survey wave as the predictor, while adjusting for demographic characteristics and nesting of participants within programs. Results: Odds of clients being current smokers was lower (AOR=0.43, 95%CI = 0.30,0.60) after implementation of TFG compared to baseline. Adjusted mean ratio (AMR) for cigarettes per day was lower post-TFG compared to baseline (AMR=0.70, CI=0.59, 0.83). There were no differences, across waves, in tobacco-related knowledge, attitudes, or services received by

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Section: Introductionmentioning

confidence: 99%

Smoking related outcomes before and after implementation of tobacco-free grounds in residential substance use disorder treatment programs

Gubner

Williams

et al. 2019

Drug and Alcohol Dependence

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“…Further, those with opioid use disorder (OUD) had a significantly higher risk of mortality from all 19 tested smoking related conditions (i.e. cardiovascular, respiratory diseases and cancers) when compared to the general population ( Callaghan, Gatley, Sykes, & Taylor, 2018 ). The observed relationship between tobacco smoking and health among people with OUD is particularly concerning given the high prevalence of smoking in this population.…”

Section: Introductionmentioning

confidence: 99%

The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder

Palis

Marchand

Karamouzian

et al. 2018

Addictive Behaviors Reports

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IntroductionPeople with chronic opioid use disorder often present to treatment with individual and structural vulnerabilities and remain at risk of reporting adverse health outcomes. This risk is greatly compounded by tobacco smoking, which is highly prevalent among people with chronic opioid use disorder. Despite the known burden of tobacco smoking on health, the relationship between nicotine dependence and health has not been studied among those receiving injectable opioid agonist treatment. As such, the present study aims to explore the association between nicotine dependence and physical health among participants of the Study to Assess Longer-Term Opioid Medication Effectiveness (SALOME) at baseline and six-months.MethodsSALOME was a double-blind phase III clinical trial testing the non-inferiority of injectable hydromorphone to injectable diacetylmorphine for chronic opioid use disorder. Participants reporting tobacco smoking were included in a linear regression analysis of physical health at baseline (before receiving treatment) and at six-months.ResultsAt baseline, nicotine dependence score, lifetime history of emotional, physical, or sexual abuse and prior month safe injection site access were independently and significantly associated with physical health. At six-months nicotine dependence score was the only variable that maintained this significant and independent association with physical health.ConclusionsFindings indicate that after six-months, the injectable treatment effectively brought equity to patients' physical health status, yet the association with nicotine dependence remained. Findings could inform whether the provision of treatment for nicotine dependence should be made a priority in settings where injectable opioid agonist treatment is delivered to achieve improvements in overall physical health in this population.

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“…It is two to 13 times more prevalent in people with other substance use disorders (SUDs) than in control subjects [2], and SUD individuals present many risk factors for more severe patterns of tobacco smoking [3]. Consequently, tobaccorelated diseases may account for 36-49% deaths of people who ever received inpatient treatment for other SUDs [4].…”

Section: Introductionmentioning

confidence: 99%

Gene-Gene interactions and pleiotropy in the brain nicotinic pathway associated with the heaviness and precocity of tobacco smoking among outpatients with multiple substance use disorders

Icick

Besson

Zerdazi

et al. 2019

Preprint

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Introduction: Tobacco smoking is a major health burden worldwide, especially in populations suffering from other substance use disorders (SUDs). Several smoking phenotypes have been associated with single nucleotide polymorphisms (SNPs) of nicotinic acetylcholine receptors (nAChRs). Yet, little is known about the genetics of tobacco smoking in populations with other SUDs, particularly regarding gene-gene interactions and pleiotropy, which are likely involved in the polygenic architecture of SUDs. Thus, we undertook a candidate pathway association study of nAChR-related genes and smoking phenotypes in a sample of SUD patients.Methods: 493 patients with genetically-verified Caucasian ancestry were characterized extensively regarding patterns of tobacco smoking, other SUDs, and 83 SNPs from the nicotinic pathway, encompassing all brain nAChR subunits and metabolic/chaperone/trafficking proteins. Single-SNP, gene-based and SNP x SNP interactions analyses were performed to investigate associations with relevant tobacco smoking phenotypes. This included Bayesian analyses to detect pleiotropy, and adjustment on clinical and sociodemographic confounders. Results:After multiple adjustment, we found independent associations between CHRNA3 rs8040868 and a higher number of cigarettes per day (CPD), and between RIC3 rs11826236 and a lower age at smoking initiation. Two SNP x SNP interactions were associated with age at onset (AAO) of daily smoking. There was pleiotropy regarding three SNPs in CHRNA3 (CPD, AAO daily smoking), ACHE (CPD, HSI) and CHRNB4 (CPD, both AAOs). Discussion:Despite limitations, the present study shows that the genetics of tobacco smoking in SUD patients are both distinct and partially shared across smoking phenotypes, and involve metabolic and chaperone effectors of the nicotinic pathway.

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The prominence of smoking‐related mortality among individuals with alcohol‐ or drug‐use disorders

Cited by 27 publications

References 43 publications

Smoking related outcomes before and after implementation of tobacco-free grounds in residential substance use disorder treatment programs

Smoking related outcomes before and after implementation of tobacco-free grounds in residential substance use disorder treatment programs

The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder

Gene-Gene interactions and pleiotropy in the brain nicotinic pathway associated with the heaviness and precocity of tobacco smoking among outpatients with multiple substance use disorders

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