The promise of lentiviral gene therapy for liver cancer

CPNE1 silencing inhibits the proliferation, invasion and migration of human osteosarcoma cells

“…It was previously reported that the C2 domains of CPNE1 may function in cell signaling and/or membrane trafficking pathways, and the A domain facilitates the binding of CPNE1 with various intracellular proteins (8,9). Lentivirus-based vectors with small hairpin RNA (shRNA) have been used as a successful tool for silencing target gene expression, particularly in cancer cells, with high specificity, stability and efficiency in vitro and in vivo (10,11). However, no valid evidence concerning the biological function of CPNE1 in osteosarcoma exists to date.…”

A Potential Targeting Gene Vector Based on Biotinylated Polyethyleneimine/Avidin Bioconjugates

“…Only a few patients with early HCC undergo orthotopic liver transplantation; nonetheless, the vast majority of patients with advanced HCC remain untreated, since other conventional therapies are mostly palliative (2). Moreover, the prognosis of patients suffering from advanced HCC remains poor despite a large number of therapeutic options (3).…”

“…Since advanced liver cancer lacks effective therapy in most cases, a considerable interest has been drawn towards the new HCC therapeutic strategies, particularly gene-based therapy (4). Despite gene therapy offering an exciting approach for treating liver cancer, it has largely been confined to preclinical and experimental settings (2,3). Fortunately, significant advances in gene therapy have been made over the past years, attributed to the development of effective gene transfer vectors (4,5).…”

Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice

“…New therapeutic strategies therefore are required to improve outcome in HCC. Among various experimental molecular anticancer treatments [4][5][6][7][8][9], anti-angiogenic treatment has emerged as a particularly exciting development [10][11][12]. Angiogenesis, required for invasive tumor growth and metastasis, represents an important control point in cancer progression [13][14][15].…”