The promise of metabolomic approaches in toxicological studies

Abstract

Metabolomics as a progressive tool for pharmaco-toxicological research is gradually proving its value in toxicity according to the strategy for making a chronological assessment of new and developing diseases. The aim of the new approaches is to use the most complete statistics to summarize information protocols using food safety protocol approaches, and to reduce the number of cases in biomodeling studies and time. The term "metabolomics" refers to the measurement of small molecules, which are the particular probability of biological systems (cells, tissues, organisms, etc.) at a particular point in time. The main purpose of the review is to give an idea of planning and a number of metabolic studies to use an arsenal of methodological approaches, incl. in arbitration toxicology.The collection and analysis of scientific publications was carried out according to the recommendation of H. Snyder for writing review articles. In Russian, they are presented in various bibliographic databases (Elibrary, Pubmed, Scopus (Elsevier), Web of Science (Clarivate)) later publications.The need for a toxicological assessment of new cases identified highlights metabolomics as the most promising method for testing the safety of pharmaceutical substances. Metabolomic studies have a high potential to detect biomarkers that indicate the toxicity of natural compounds.

Metabolomic studies for medicinal plant raw materials

“…Метаболизм растений изменяется в зависимости от генетических факторов, а также различных физиологических факторов и факторов окружающей среды. На помощь в таких масштабных исследованиях приходит метаболомика [4]. Понятие «метаболом» впервые было предложено в 1998 г. Стивену Оливеру за обозначение низкомолекулярных соединений, синтезируемых организмом [5].…”