The promise of pharmacogenetics in labor analgesia…tantalizing, but not there yet

Wong, Cynthia A.

doi:10.1016/j.ijoa.2012.02.003

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…The major challenge remains to design studies with a crisp phenotype in the context of labor pain. [48]. Most existing studies seem to have been underpowered [19,49], or to not have taken into account ethnic and cultural differences [22] or the impact of hospital and local practice [10].…”

Section: Comt and Intravenous Fentanyl For Labor Analgesiamentioning

confidence: 99%

The Impact of Genetics and Other Factors on Intra- and Post-partum Pain

Landau

Ortner

Vuilleumier

2013

Curr Anesthesiol Rep

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In an attempt to provide some explanation for the observed differences in pain perception and analgesic requirements during labor and delivery between women, the idea that genetic variability is an important factor has emerged over the past decade. Bearing in mind the challenges posed when evaluating pain during childbirth as a phenotype, recent findings in the field of genetics and obstetric anesthesia are presented in this review; in particular those related to differences in labor analgesia requirements between women, the response to opioids after cesarean delivery, as well as theories on why post-cesarean pain may be different from other types of post-surgical pain.

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Section: Comt and Intravenous Fentanyl For Labor Analgesiamentioning

confidence: 99%

The Impact of Genetics and Other Factors on Intra- and Post-partum Pain

Landau

Ortner

Vuilleumier

2013

Curr Anesthesiol Rep

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“…Interindividual variability is a key fea ture of human pain at all levels, with labor pain being no exception [96,97]. Influences of nurture include psychological and personality factors, such as previous pain experience, emotionality, cognition, somatization, catastrophizing, acute and chronic stressful life events, fatigue, anxiety, fear and anticipation, and socioeconomic factors, such as social support, incentives, education and quality of life.…”

Section: Genetics Labor Pain and The Futurementioning

confidence: 99%

Analgesia for Childbirth: Modern Insights Into an Age-Old Challenge and the Quest for an Ideal Approach

Tulp

Paech

2013

Pain Manage.

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It is widely recognized that childbirth may be the most painful experience in a woman's lifetime and that women have a right to relief. There are many options, but the efficacy of only a few is supported by robust evidence. Many influences determine which method of pain relief is chosen, including social and cultural factors, availability, cost and personal preference. Due to human diversity and the differing perspectives of consumers, obstetric care providers and health administrators, there is no such thing as 'an ideal approach'. In resource-rich societies, major advances in parturient safety and outcome flow from technique development and better monitoring. Greater awareness of the negative impact of untreated pain and of the relevance of genetic, cultural and social factors motivates research into better predictive models, novel therapies and optimization of existing methods.

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Pharmacogenetics in obstetric anesthesia

Landau

Smiley

2017

Best Practice & Research Clinical Anaesthesiology

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The promise of pharmacogenetics in labor analgesia…tantalizing, but not there yet

Cited by 6 publications

References 28 publications

The Impact of Genetics and Other Factors on Intra- and Post-partum Pain

The Impact of Genetics and Other Factors on Intra- and Post-partum Pain

Analgesia for Childbirth: Modern Insights Into an Age-Old Challenge and the Quest for an Ideal Approach

Pharmacogenetics in obstetric anesthesia

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