The promoting effect of adiponectin in hepatocellular carcinoma

Chen, Ming-Jenn; Yeh, Yao‐Tsung; Lee, King-Teh; Tsai, Chi‐Cheng; Lee, Hao-Hsien; Wang, Shen‐Nien

doi:10.1002/jso.23059

Cited by 47 publications

(45 citation statements)

References 31 publications

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“…[34, 35], [36] Elevated adiponectin expression may also correlate with worsened outcome, as noted by a report from Taiwan which suggested that high cytoplasmic staining of HCC tumors with adiponectin was associated with recurrence and worsened survival, possibly via upregulation of AKT. This finding persisted after controlling for BMI and fasting blood sugar.…”

Section: Discussionmentioning

confidence: 99%

Serum Adiponectin Is Associated with Worsened Overall Survival in a Prospective Cohort of Hepatocellular Carcinoma Patients

et al. 2014

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Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. The rise in metabolic syndrome has contributed to this trend. Adipokines, such as adiponectin, are associated with prognosis in several cancers, but have not been well studied in HCC. Methods: We prospectively enrolled 140 patients with newly diagnosed or recurrent HCC with Child-Pugh (CP) class A or B cirrhosis. We examined associations between serum adipokines, clinicopathological features of HCC, and time to death. We also examined a subset of tumors with available pathology for tissue adiponectin receptor (AR) expression by immunohistochemistry. Results: The median age of subjects was 62 years; 79% were men, 59% had underlying hepatitis C, and 36% were diabetic. Adiponectin remained a significant predictor of time to death (hazard ratio 1.90; 95% confidence interval 1.05-3.45; p = 0.03) in a multivariable adjusted model that included age, alcohol history, CP class, stage, and serum E-fetoprotein level. Cytoplasmic AR expression (AR1 and AR2) in tumors trended higher in those with higher serum adiponectin levels and in those with diabetes mellitus, but the association was not statistically significant. Conclusions: In this hypothesis-generating study, we found the serum adiponectin level to be an independent predictor of overall survival in a diverse cohort of HCC patients. Impact: Understanding how adipokines affect the HCC outcome may help develop novel treatment and prevention strategies. i 2014 S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

Serum Adiponectin Is Associated with Worsened Overall Survival in a Prospective Cohort of Hepatocellular Carcinoma Patients

et al. 2014

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“…p27 has been considered as a tumor suppressor gene, with p27 dysfunction causing excess cell cycle activity and carcinogenosis 68 . In these HepG2 and MCF-7 cell lines, gAcrp induced Fas ligand activity and hence promoted apoptosis 67 .…”

Section: Apn Signallingmentioning

confidence: 99%

Evolving role of adiponectin in cancer-controversies and update

Katira¹,

Tan²

2016

Cancer Biology &Amp; Medicine

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Adiponectin (APN), an adipokine produced by adipocytes, has been shown to have a critical role in the pathogenesis of obesityassociated malignancies. Through its receptor interactions, APN may exert its anti-carcinogenic effects including regulating cell survival, apoptosis and metastasis via a plethora of signalling pathways. Despite the strong evidence supporting this notion, some work may indicate otherwise. Our review addresses all controversies critically. On the whole, hypoadiponectinaemia is associated with increased risk of several malignancies and poor prognosis. In addition, various genetic polymorphisms may predispose individuals to increased risk of obesity-associated malignancies. We also provide an updated summary on therapeutic interventions to increase APN levels that are of key interest in this field. To date efforts to manipulate APN levels have been promising, but much work remains to be done.

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“…In chronic hepatitis B, 40 patients with cirrhosis and 120 patients with HCC demonstrated markedly increased serum adiponectin levels [31]. Increased serum levels in HCC patients were also observed in another study which showed increased adiponectin expression in HCC tumor samples [32]. Another study assessing cirrhotic and non-cirrhotic HCC patients found increased serum levels of both adiponectin and leptin in this patient population [33].…”

Section: Adipocytokines and Their Role In Hccmentioning

confidence: 77%

Adipocytokines and Hepatocellular Carcinoma

Wieser

Moschen²,

Tilg³

2012

Dig Dis

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Adipocytokines are primarily adipocyte-derived products, although certain members are also synthesized by other cell types. These adipocytokines, similarly to classical cytokines, are characterized by very pleiotropic functions affecting biological processes throughout the body. An increasing number of adipocytokines has recently been recognized, such as adiponectin, leptin, pre-B cell colony-enhancing factor/Nampt/visfatin, resistin, progranulin, and others. Adiponectin has emerged as the most abundant circulating adipocytokine, is produced almost exclusively by adipocytes, and has mainly anti-inflammatory and anti-diabetic functions. In contrast, leptin is produced by many cell types beyond adipocytes, regulates immunity and T cell functions, and acts in a more pro-inflammatory fashion. Adipocytokines play a fundamental role in adipose tissue homeostasis (i.e. health) and disease, especially in obesity-related disorders such as non-alcoholic fatty liver diseases (NAFLD) and their complications, including hepatocellular carcinoma (HCC). Lack of adiponectin as observed in NAFLD drives steatosis and inflammation in the liver, and evidence is increasing that this adipocytokine has many anti-tumor properties and might play a rather protective role in HCC. The role of leptin in NAFLD is still unclear and this adipocytokine seems to have opposite effects in HCC, acting more as a tumor promoter. Evidence is increasing that HCC tissue produces various adipocytokines, and adiponectin expression in HCC seems to be decreased whereas leptin expression is rather increased. In conclusion, adipocytokines are increasingly recognized as pleiotropic molecules involved in the pathophysiology of HCC, which might lead to therapeutic approaches targeting these mediators.

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The promoting effect of adiponectin in hepatocellular carcinoma

Abstract: Increased adiponectin expressions were found in HCC and this increase might contribute to tumor growth.

Cited by 47 publications

References 31 publications

Serum Adiponectin Is Associated with Worsened Overall Survival in a Prospective Cohort of Hepatocellular Carcinoma Patients

Serum Adiponectin Is Associated with Worsened Overall Survival in a Prospective Cohort of Hepatocellular Carcinoma Patients

Evolving role of adiponectin in cancer-controversies and update

Adipocytokines and Hepatocellular Carcinoma

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