The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN)

Alhazmi, Nada; Pai, Chun Peng; Albaqami, Aljawharah; Wang, Han; Zhao, Xuan; Chen, Minyue; Hu, Po; Guo, Shuang; Starost, Kyle A.; Hajihassani, Omid; Miyagi, Masaru; Kao, Hung Ying

doi:10.1016/j.bbamcr.2020.118707

Cited by 12 publications

(8 citation statements)

References 34 publications

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“…Previous cell-based and human studies have indicated that sulforaphane exposure is associated with decreased breast cancer progression, including initiating cell cycle arrest and apoptosis ( Kuran et al, 2020 ). Sulforaphane treatment led to the inhibition of cell proliferation of breast cancer cells lines, MCF-7 and MDA-MB-231 and provoked cytotoxic activity by changing cysteine residues of the promyelocytic leukemia protein, known to promote proliferation of the MCF-7 breast cancer cell line ( Alhazmi et al, 2020 ). Sulforaphane has also been shown to modify cell migration and expression of epithelial mesenchymal transition markers that play a large role in breast cancer metastasis ( Bagheri et al, 2020 ).…”

Section: Glucosinolates From Cruciferous Vegetables and Human Healthmentioning

confidence: 99%

Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence

et al. 2021

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An increasing body of evidence highlights the strong potential for a diet rich in fruit and vegetables to delay, and often prevent, the onset of chronic diseases, including cardiometabolic, neurological, and musculoskeletal conditions, and certain cancers. A possible protective component, glucosinolates, which are phytochemicals found almost exclusively in cruciferous vegetables, have been identified from preclinical and clinical studies. Current research suggests that glucosinolates (and isothiocyanates) act via several mechanisms, ultimately exhibiting anti-inflammatory, antioxidant, and chemo-protective effects. This review summarizes the current knowledge surrounding cruciferous vegetables and their glucosinolates in relation to the specified health conditions. Although there is evidence that consumption of a high glucosinolate diet is linked with reduced incidence of chronic diseases, future large-scale placebo-controlled human trials including standardized glucosinolate supplements are needed.

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Section: Glucosinolates From Cruciferous Vegetables and Human Healthmentioning

confidence: 99%

Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence

et al. 2021

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“…Like Ub, SUMO can be conjugated either as a monomer or as a polymeric chain. Mono‐sumoylation mainly regulates protein–protein interactions through SUMO‐interacting motifs (SIMs), which help assemble multisubunit complexes and mediate protein accumulation in subnuclear compartments such as NPCs or PML nuclear bodies [10,11]. In mammals, poly‐SUMO chains are formed by SUMO2/3 linked through their Lys11 residue, while SUMO1 can act as a chain terminator, capping a poly‐SUMO2/3 chain [6,7,12].…”

Section: Mechanisms Of Ubiquitination and Sumoylationmentioning

confidence: 99%

SUMO in the regulation of DNA repair and transcription at nuclear pores

Gasser,

Stutz

2023

FEBS Letters

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Two related post‐translational modifications, the covalent linkage of Ubiquitin and the Small Ubiquitin‐related MOdifier (SUMO) to lysine residues, play key roles in the regulation of both DNA repair pathway choice and transcription. Whereas ubiquitination is generally associated with protein degradation, the impact of sumoylation has been more mysterious. Sumoylation effects are largely mediated by the subnuclear localization of its targets, particularly in response to DNA damage. This is governed in part by the concentration of SUMO protease at nuclear pores (1,2). We review here the roles of sumoylation in determining subnuclear locus positioning relative to the nuclear envelope and the nuclear envelope to facilitate repair and to regulate transcription.

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“…PML is an exquisitely oxidation-sensitive protein and a physiological sensor for ROS, which promote PML NB formation, similar to ATO ( Guan et al, 2014 ; Guo et al, 2014b ; Niwa-Kawakita et al, 2017 ; Sahin et al, 2014b ). Importantly, PML was implicated in multiple forms of oxidative stress responses ( Alhazmi et al, 2020 ; Niwa-Kawakita et al, 2017 ; Sahin et al, 2014b ) and hypoxia signaling ( Bernardi et al, 2006 ; Salsman et al, 2017 ; Yuan et al, 2011 ). P53 targets and the antioxidant response (NRF2 targets) are activated following acute oxidative stress in a PML-dependent manner ( Guo et al, 2014b ; Malloy et al, 2013 ; Niwa-Kawakita et al, 2017 ).…”

Section: Pml Nuclear Bodies Are Dynamic and Stress-sensitive Structuresmentioning

confidence: 99%

The PML hub: An emerging actor of leukemia therapies

Rérolle

Thé

2023

Journal of Experimental Medicine

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PML assembles into nuclear domains that have attracted considerable attention from cell and cancer biologists. Upon stress, PML nuclear bodies modulate sumoylation and other post-translational modifications, providing an integrated molecular framework for the multiple roles of PML in apoptosis, senescence, or metabolism. PML is both a sensor and an effector of oxidative stress. Emerging data has demonstrated its key role in promoting therapy response in several hematological malignancies. While these membrane-less nuclear hubs can enforce efficient cancer cell clearance, their downstream pathways deserve better characterization. PML NBs are druggable and their known modulators may have broader clinical utilities than initially thought.

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The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN)

Cited by 12 publications

References 34 publications

Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence

Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence

SUMO in the regulation of DNA repair and transcription at nuclear pores

The PML hub: An emerging actor of leukemia therapies

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