The Pronuclei - 20 Years Later

Analysis for the Combinations of Histone Modifications inS.Cerevisiae

“…Subsequently, it has emerged that lysine acetylation and other posttranslational modifications of histones generated binding sites for specific protein-protein interaction domains, such as the acetyl-lysine binding bromodomain (2). In general, acetylation of core histone tails correlates with opening of chromatin structure to allow transcription activation (14,24).…”