The prooxidant effect of sodium metabisulfite in rat liver and kidney

Elmas, Oğuz; Aslan, Mutay; Caglar, Serkan; Derın, Narin; Ağar, Ayşel; Alicigüzel, Yakup; Yargiçoğlu, Pi̇raye

doi:10.1016/j.yrtph.2005.01.010

Cited by 57 publications

(47 citation statements)

References 45 publications

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“…It has been suggested that many of the clinical and pathological manifestations result from an imbalance between free radical defense system and free radical production. The increase in free radical production has increased the potential for free radicalmediated tissue damage (Ercan et al, 2010 (Elmas et al, 2005). The result of the present study showed that there was significant increase in the activity of SOD of MBS-treated rats when compared to the control.…”

Section: Discussionmentioning

confidence: 52%

“…and a sulfate radical (SO 4 -. ), which in turn reacts with lipids (Elmas et al, 2005;Ercan et al, 2010). Also, the oneelectron oxidation of bisulphate produces the sulfur trioxide radical anion, which reacts rapidly with molecular oxygen to form peroxyl radical.…”

Section: Discussionmentioning

confidence: 99%

“…The increase activity of SOD in the dismutation of superoxide radicals is expected to result in increase hydrogen peroxide generation. SOD is considered as the first line of defense against oxygen toxicity (Meng and Zhan, 2001;Meng and Zhang, 2003 (Elmas et al, 2005) or catalase, another primary scavengers of hydrogen peroxide (Laggner et al, 2005), which cannot be saturated by H 2 O 2 at any concentration. SOD and CAT also remove (O 2 . )…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Considerable amount of sulfites is generated in vivo from the catabolism of sulfur-containing amino acids such as cysteine and methionine Elmas et al, 2005). Five sulfite salts including sodium metabisulfite (Na 2 S 2 O 5 ), potassium metabisulfite (K 2 S 2 O 5 ), sodium sulfite (Na 2 SO 3 ), sodium bisulfite (NaHSO 3 ), potassium sulfite (K 2 SO 3 ) are commonly used as antioxidants in food preparations (Elmas et al, 2005). In addition to this, studies have postulated that under certain conditions, sodium metabisulfite may act through cell disruption and compromise membrane permeability and lipid peroxidation (Derin et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Oxidative damage on the testes of adult rats by sodium metabisulfite (MBS)

Adebayo¹,

Adenuga²

2012

Int. J. Bio. Chem. Sci

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The effect of sodium metabisulfite (MBS, Na 2 S 2 O 5 ) on the level of malondialdehyde (MDA), testes weight and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) as well as the level of glutathione (GSH) were investigated in the testes of Wistar albino rats. The study was performed to elucidate the effect of MBS (520 mg/kg/day) ingestion on lipid peroxidation and the antioxidant enzymes activities. The results showed that MDA level as well as the activity of SOD was significantly increased in MBS-treated rats whereas the weight of the testes as well as the level of GSH was not significantly affected. However, there was significant reduction in the activity of CAT in the MBS-treated rats compared to the control. The presented data showed that ingestion of MBS has adverse effect on testes as it induced oxidative damage, reflected by increase lipid peroxidation and impairment in the activities of antioxidant enzymes.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Oxidative damage on the testes of adult rats by sodium metabisulfite (MBS)

Adebayo¹,

Adenuga²

2012

Int. J. Bio. Chem. Sci

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Sulfite increases lipoperoxidation and decreases the activity of catalase in brain of rats

et al. 2007

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The main objective of this study was to investigate the in vitro effects of sulfite, a metabolite accumulated in isolated sulfite oxidase deficiency, on Na (+), K (+)-ATPase activity and on some parameters of oxidative stress, namely thiobarbituric acid-reactive substances (TBARS) and catalase activity (antioxidant enzyme) in cerebral cortex, striatum and hippocampus from 10- and 60-day-old rats. Results showed that 500 microM sulfite significantly increased TBARS and reduced catalase activity in the cerebral structures studied from neonates and adults rats; in contrast, sulfite did not alter Na(+), K(+)-ATPase activity. Our present findings show that sulfite increases lipid peroxidation and decreases antioxidant enzyme defenses in rat brain, suggesting an induction of oxidative stress. We presumed that oxidative stress might be, at least in part, associated with the neuronal dysfunction of patients affected by isolated sulfite oxidase deficiency.

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Inactivation of deoxynivalenol-contaminated cereal grains with sodium metabisulfite: a review of procedures and toxicological aspects

et al. 2012

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Both hydrothermal treatment and wet preservation of mainly deoxynivalenol (DON)-containing, Fusarium toxin (FUS)-contaminated cereal grains with sodium metabisulfite (Na2S2O5 [SBS]) were successfully demonstrated to reduce the DON contamination through formation of the sulfonated derivative of DON, termed as DON sulfonate (DONS). The wet preservation is particularly interesting from a practical viewpoint as it can be easily performed at the farm level where the cereal grains are harvested and utilized in pig feeding. This review compiles the literature with regard to the chemical characterization and the detection of DONS, technical procedures and their efficacies, toxicological aspects and toxic effects of DON, DONS and SBS, and detection of DONS, DON and further metabolites in physiological specimens of pigs.

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The prooxidant effect of sodium metabisulfite in rat liver and kidney

Cited by 57 publications

References 45 publications

Oxidative damage on the testes of adult rats by sodium metabisulfite (MBS)

Oxidative damage on the testes of adult rats by sodium metabisulfite (MBS)

Sulfite increases lipoperoxidation and decreases the activity of catalase in brain of rats

Inactivation of deoxynivalenol-contaminated cereal grains with sodium metabisulfite: a review of procedures and toxicological aspects

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