The properties of ACh-induced BK currents in guinea pig type II vestibular hair cells

Kong, Weijia; Guo, Chang-Kai; Zhang, Song; Jin, Hao; Wang, Yanjun; Li, Zhiwang

doi:10.1016/j.heares.2005.06.001

Cited by 32 publications

(46 citation statements)

References 56 publications

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“…Experiments on the cholinergic modulation of the fAHP current have produced more conflicting results. Cholinergic agonists either cause fAHP increase (Bordey et al 2000;Kong et al 2005), no change in fAHP (Lorenzon and Foehring 1992;Storm 1987), or affect fAHP depending on the membrane potential, but probably causes increase under normal conditions (Akins et al 1990;Cox et al 1997;Hicks and Marrion 1998;Kong et al 2007;Nakajima et al 1986;Schreiber and Salkoff 1997). These physiological findings are described in further detail and compared with model parameters in the Section 2.…”

Section: Acetylcholine Alters After-hyperpolarization Currentmentioning

confidence: 94%

“…A variety of later work, albeit mainly non-cortical or non-pyramidal, supports the hypothesis that ACh stimulation causes an increase in fAHP conductance. Stimulation with ACh elevates fAHP current via muscarinic receptors in cancerous astrocytes of human neocortex (Bordey et al 2000) and amplifies fAHP currents via nicotinic receptors in vestibular hair cells of pigs (Kong et al 2005). Similarly, in rat sympathetic neurons, BK channels activate with calcium influx as a result of ACh receptor activation (Prakriya et al 1996;Prakriya and Lingle 1999).…”

Section: Modeling Acetylcholine Modulationmentioning

confidence: 99%

“…Nonetheless, at hyperpolarized membrane voltage near rest, approximately −70 mV, it appears that both studies show an increase in fAHP from the modulatory signal. In the vestibular hair cells of the guinea pig, ACh-induced BK currents exhibit a reversal potential of around −65 mV (Kong et al 2005;. The studies from Kong and colleagues are of particular interest, because they show graded changes in BK current with rising levels of ACh.…”

Section: Modeling Acetylcholine Modulationmentioning

confidence: 99%

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After-hyperpolarization currents and acetylcholine control sigmoid transfer functions in a spiking cortical model

2011

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Recurrent networks are ubiquitous in the brain, where they enable a diverse set of transformations during perception, cognition, emotion, and action. It has been known since the 1970's how, in rate-based recurrent on-center off-surround networks, the choice of feedback signal function can control the transformation of input patterns into activity patterns that are stored in short term memory. A sigmoid signal function may, in particular, control a quenching threshold below which inputs are suppressed as noise and above which they may be contrast enhanced before the resulting activity pattern is stored. The threshold and slope of the sigmoid signal function determine the degree of noise suppression and of contrast enhancement. This article analyses how sigmoid signal functions and their shape may be determined in biophysically realistic spiking neurons. Combinations of fast, medium, and slow after-hyperpolarization (AHP) currents, and their modulation by acetylcholine (ACh), can control sigmoid signal threshold and slope. Instead of a simple gain in excitability that was previously attributed to ACh, cholinergic modulation may cause translation of the sigmoid threshold. This property clarifies how activation of ACh by basal forebrain circuits, notably the nucleus basalis of Meynert, may alter the vigilance of category learning circuits, and thus their sensitivity to predictive mismatches, thereby controlling whether learned categories code concrete or abstract information, as predicted by Adaptive Resonance Theory.

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Section: Acetylcholine Alters After-hyperpolarization Currentmentioning

confidence: 94%

Section: Modeling Acetylcholine Modulationmentioning

confidence: 99%

Section: Modeling Acetylcholine Modulationmentioning

confidence: 99%

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After-hyperpolarization currents and acetylcholine control sigmoid transfer functions in a spiking cortical model

2011

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“…The muscarinic receptor subtypes are further divided into two groups in terms of their intracellular cascades [17,18] . The M1, M3 and M5 subtypes are linked through Gq and phospholipase C to cause inositol 1, 4, 5-triphosphate-mediated intracellular Ca 2+ release and diacylglycerol-mediated activation of protein kinase C. The M2 and M4 subtypes inhibit adenylyl cyclase via Gi proteins or Go proteins [17][18][19][20] , the groups sharing some similar biochemical features [18] .In the previous studies, we found ACh could stimulate a large conductance, Ca 2+ -activated K + current (BK) in guinea pig VHCs Ⅱ by activating the influx of Ca 2+ ions, which is mediated by an ACh receptor that could not be definitely identified as the odd-number muscarinic receptor [21] . Physiological, immunohistochemical, and molecular biological techniques have been utilized to demonstrate the presence of functional mAChRs in the vestibule [10,13,22,23] .…”

mentioning

confidence: 96%

“…In the previous studies, we found ACh could stimulate a large conductance, Ca 2+ -activated K + current (BK) in guinea pig VHCs Ⅱ by activating the influx of Ca 2+ ions, which is mediated by an ACh receptor that could not be definitely identified as the odd-number muscarinic receptor [21] . Physiological, immunohistochemical, and molecular biological techniques have been utilized to demonstrate the presence of functional mAChRs in the vestibule [10,13,22,23] .…”

mentioning

confidence: 99%

Muscarinic acetylcholine receptor subtype expression in type vestibular hair cells of guinea pigs

Yao

Cheng

Guo

et al. 2011

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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Recent studies have demonstrated that five subtypes (M1-M5) of muscarinic acetylcholine receptor (mAChR) are expressed in the vestibular periphery. However, the exact cellular location of the mAChRs is not clear. In this study, we investigated whether there is the expression of M1-M5 muscarinic receptor mRNA in isolated type II vestibular hair cells of guinea pig by using single-cell RT-PCR. In vestibular end-organ, cDNA of the expected size was obtained by RT-PCR. Moreover, mRNA was identified by RT-PCR from individually isolated type II vestibular hair cells (single-cell RT-PCR). Sequence analysis confirmed that the products were M1-M5 mAChR. These results demonstrated that M1-M5 mAChR was expressed in the type II vestibular hair cells of the guinea pig, which lends further support for the role of M1-M5 mAChR as a mediator of efferent cholinergic signalling pathway in vestibular hair cells.

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Purinergic signaling in the peripheral vestibular system

Kim

Choi

2022

Purinergic Signalling

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The inner ear comprises the cochlea and vestibular system, which detect sound and acceleration stimulation, respectively. The function of the inner ear is regulated by ion transport activity among sensory epithelial cells, neuronal cells, non-sensory epithelial cells, and luminal fluid with a unique ionic composition of high [K + ] and low [Na + ], which enables normal hearing and balance maintenance. One of the important mechanisms regulating ion transport in the inner ear is purinergic signaling. Various purinergic receptors are distributed throughout inner ear epithelial cells and neuronal cells. To date, most studies have focused on the role of purinergic receptors in the cochlea, and few studies have examined these receptors in the vestibular system. As purinergic receptors play an important role in the cochlea, they would likely do the same in the vestibular system, which is fairly similar to the cochlea in cellular structure and function. Based on available studies performed to date, purinergic signaling is postulated to be involved in the regulation of ion homeostasis, protection of hair cells, otoconia formation, and regulation of electrical signaling from the sensory epithelium to vestibular neurons. In this review, the distribution and roles of purinergic receptors in the peripheral vestibular system are summarized and discussed.

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The properties of ACh-induced BK currents in guinea pig type II vestibular hair cells

Cited by 32 publications

References 56 publications

After-hyperpolarization currents and acetylcholine control sigmoid transfer functions in a spiking cortical model

After-hyperpolarization currents and acetylcholine control sigmoid transfer functions in a spiking cortical model

Muscarinic acetylcholine receptor subtype expression in type vestibular hair cells of guinea pigs

Purinergic signaling in the peripheral vestibular system

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