The properties of disorders of carbohydrate metabolism in elderly patients with gout and metabolic syndrome

Kunitskaya, N.; Ariev, A L

doi:10.1134/s2079057012040108

Cited by 3 publications

(3 citation statements)

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“…High levels of serum LPS can induce chronic inflammation, which is closely related to metabolic syndromes such as obesity, insulin resistance, and other diseases. 172,173 In a metabolic disorder model, serum LPS levels were reduced when mice were treated with probiotics. 18 Chronic inflammation caused by elevated serum LPS levels is often accompanied by an increase in XOD activity.…”

Section: Modulation Of the Effects Of Probiotics On Hyperuricemia-ind...mentioning

confidence: 99%

The potential of probiotics in the amelioration of hyperuricemia

Zhao

2022

Food Funct.

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Section: Modulation Of the Effects Of Probiotics On Hyperuricemia-ind...mentioning

confidence: 99%

The potential of probiotics in the amelioration of hyperuricemia

Zhao

2022

Food Funct.

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“…This indicates that there is no evidence for the association of uric acid with cognitive impairment. Complementary to that, a recent study demonstrated the neuroprotective effect of uric acid in the development of Alzheimer's disease and dementia in Parkinson's disease patients, while hypouricemia was found to be associated with the progression of these diseases [33]. Further investigation inti the role of uric acid in the development of memory disorders at the predementia stage requires a separate study.…”

Section: Discussionmentioning

confidence: 83%

The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of Russia

Poskotinova,

Kontsevaya,

Kudryavtsev

2023

Brain Sciences

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The prevention of memory decline requires better knowledge of biological markers. We studied the associations between kidney function biomarkers and memory decline (assessed with the Mini-Mental State Examination—MMSE) in elderly individuals without dementia (MMSE 24–30, age 60–74 years, n = 643, Arkhangelsk, Russia). Participants were divided by sex and into three groups according to the delayed memory performance: recall of 0–1, 2, and 3 out of 3 words. The median of serum creatinine was 82 μmol/L in men who recalled 2 words and both medians in those recalling 3 and 0–1 words were 87 μmol/L. The 90th percentile for creatinine in men recalling 0–1 words (115.0 μmol/L) exceeded the upper limit of the normal range (110.5 μmol/L), while those who recalled 3 and 2 words had 90th percentiles within the normal range (109 and 101 μmol/L, respectively). Glomerular filtration rates were normal (≥60 mL/min/1.73 m2) with a median of 92.0 mL/min/1.73 m2 in men who recalled 2 words, 84.4 and 84.9 mL/min/1.73 m2 in men who recalled 3 and 0–1 words, respectively. None of these associations were observed in women. A reduced serum creatinine in older non-demented men may indicate the initial stages of memory decline, while the increased creatinine may reflect further stages of memory impairment.

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“…Another interesting study found that gut dysbacteriosis can increase intestinal permeability and promote the translocation of bacteria or bacterial products, such as lipopolysaccharide [LPS ( 136 )]. High levels of serum LPS can induce chronic inflammation and increase the risk of hyperuricemia ( 137 ). The high levels of LPS sustained in gout are positively related to the abundance of Gram-negative bacteria in the intestine, especially Proteobacteria ( 138 ).…”

Section: Manuscript Formattingmentioning

confidence: 99%

The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout

Fang

Chen

et al. 2022

Front. Nutr.

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With the worldwide epidemics of hyperuricemia and associated gout, the diseases with purine metabolic disorders have become a serious threat to human public health. Accumulating evidence has shown that they have been linked to increased consumption of fructose in humans, we hereby made a timely review on the roles of fructose intake and the gut microbiota in regulating purine metabolism, together with the potential mechanisms by which excessive fructose intake contributes to hyperuricemia and gout. To this end, we focus on the understanding of the interaction between a fructose-rich diet and the gut microbiota in hyperuricemia and gout to seek for safe, cheap, and side-effect-free clinical interventions. Furthermore, fructose intake recommendations for hyperuricemia and gout patients, as well as the variety of probiotics and prebiotics with uric acid-lowering effects targeting the intestinal tract are also summarized to provide reference and guidance for the further research.

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The properties of disorders of carbohydrate metabolism in elderly patients with gout and metabolic syndrome

Cited by 3 publications

References 23 publications

The potential of probiotics in the amelioration of hyperuricemia

The potential of probiotics in the amelioration of hyperuricemia

The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of Russia

The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout

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