The prophylactic effect of intravenous magnesium infusion on postoperative sore throat after thyroid surgery. A randomized clinical trial

Mostafa, Raham Hasan; Saleh, Ashraf Nabil; Ibrahim, Ibrahim Mohamed

doi:10.25237/revchilanestv49n04-09

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many routes of administration have been used for MgSO 4 such as IV, nebulization, gargle, and lozenges. [15][16][17][18][19] The incidence of POST was less with group nebulized with magnesium, that is, Group N (29% at 0 h) compared to Group I where magnesium was administered intravenously (52.86% at 0 h). The incidence at the 1 st h (29.17% vs. 52.86%) and at the 6 th h (25% vs. 48.57%) also showed lesser POST in Group N nebulized with magnesium sulfate.…”

Section: Discussionmentioning

confidence: 99%

“…Incidence of POST in the previous studies with IV magnesium sulfate was 37.5-50% and with nebulized magnesium sulfate was 19.2-30%. 15,[19][20][21] Hence, sample size was estimated based on the previous study of Sheikh et al, 17 where the incidence of POST was 48% with IV magnesium sulfate. Assuming a reduction of 50% in incidence with nebulized magnesium sulfate with alpha error 0.05 and power 80%, we acquired sample size of 68 per group.…”

Section: Sample Size Calculation and Statistical Analysismentioning

confidence: 99%

See 1 more Smart Citation

Comparison of intravenous route versus nebulization of magnesium sulfate (MgSO4) for post-operative sore throat and hoarseness: A randomized comparative double-blinded clinical trial

2022

View full text Add to dashboard Cite

Background: Multiple drugs in different routes have been studied for the treatment of post-operative sore throat (POST). We are studying effect of magnesium sulfate on POST in two different routes. Aims and Objectives: This study aims to compare the efficacy of nebulization versus intravenous (IV) magnesium sulfate in reducing incidence of POST and hoarseness of voice. Materials and Methods: This prospective randomized double-blind study was done on 150 patients undergoing unilateral percutaneous nephrolithotomy (PCNL) surgeries under general anesthesia. Patients were randomly allocated into Group N (n=75) and Group I (n=75). Group N received 10 mg/kg MgSO4 in 5 mL of normal saline as nebulization 20 min before induction and 100 mL normal saline IV over 20 min post-induction. Group I received 5 mL of normal saline as nebulization pre-induction and 10 mg/kg MgSO4 in 100 mL saline IV over 20 min post-induction. Postoperatively, visual analog scale (VAS) score was used for the assessment of sore throat at rest and dynamic VAS (DyVAS) for pain during swallowing at the 0, 1st, 6th, 12th, and 24th h. Post-operative hoarseness graded on 4-point score was also assessed. Results: Incidence of POST in Group N was 29.17% compared to 52.86% in Group I at 0 h which was lower and statistically significant and results were alike at the 1st and 6th h. The VAS at rest and DyVAS were lower and statistically significant in Group N compared to Group I at the 0, 1st, and 6th h. Conclusion: Incidence of POST was significantly less with nebulized route of magnesium sulfate compared to IV route of magnesium sulfate.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Sample Size Calculation and Statistical Analysismentioning

confidence: 99%

Comparison of intravenous route versus nebulization of magnesium sulfate (MgSO4) for post-operative sore throat and hoarseness: A randomized comparative double-blinded clinical trial

2022

View full text Add to dashboard Cite

show abstract

“…The reports regarding the analgesic efficacy of magnesium sulfate have been controversial [13,[18][19][20]. Mostafa et al [15] evaluated the prophylactic effect of intravenous infusion of magnesium on postoperative sore throat after thyroid surgery. They evaluated 80 female patients in two groups of 30 mg/kg magnesium sulfate (test) and isotonic saline (control).…”

Section: Discussionmentioning

confidence: 99%

“…The reports regarding the analgesic efficacy of magnesium sulfate have also been controversial [13,14]. Mostafa et al [15] evaluated the prophylactic effect of intravenous infusion of magnesium on postoperative sore throat after thyroid surgery and reported that it significantly decreased the incidence and severity of sore throat after thyroidectomy. Hamed and Al-Saeed [16] assessed the efficacy of intravenous magnesium sulfate versus intravenous paracetamol on pain in children after tonsillectomy and the need for analgesics and reported that magnesium sulfate had superior analgesic efficacy compared with paracetamol, and decreased the need for analgesics.…”

Section: Introductionmentioning

confidence: 99%

Effect of Paracetamol and Magnesium Sulfate on Level of Pain and Opioid Intake following Orthognathic Surgery: A Clinical Trial

Khalili

Farazmehr²,

Shafaeefard³

et al. 2022

J Res Dent Maxillofac Sci

View full text Add to dashboard Cite

Background and Aim: Considering the side effects of high doses of opioids taken postoperatively for pain control, paracetamol and magnesium sulfate may be able to aid in pain control. This study assessed the effects of paracetamol and magnesium sulfate on the level of pain and opioid intake following orthognathic surgery. Materials and Methods: In this double-blind randomized clinical trial, patients scheduled for bimaxillary orthognathic surgery were randomly assigned to two groups of 25. Group 1 patients received 1 g infusion of intravenous acetaminophen (paracetamol) administered within 20 minutes while group 2 patients received 50 mg/kg magnesium sulfate infusion one hour prior to completion of surgery. The patients were asked to express their level of pain prior to discharge from the recovery, and every 4 hours for 12 hours using a visual analog scale (VAS). Patients with pain score > 5 at any time received 30 mg pethidine. The total received dosage of pethidine postoperatively was recorded and those that received pethidine were not included in pain score analysis. Data were analyzed by generalized estimating equation (GEE), and Mann-Whitney U, Chi-square, and t-tests. Results: The pain score was not significantly different between the two groups at the time of recovery and 4 and 8 hours (P>0.05). The magnesium sulfate group had significantly lower pain score at 12 hours (P=0.009). The difference in pethidine dosage was not significant (P>0.05). Conclusion: Both magnesium sulfate and paracetamol decreased postoperative pain and the need for opioid consumption, but magnesium sulfate was slightly more effective.

show abstract

Effect of intra-operative Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients undergoing lumbar fixation: a randomized controlled trial

Fathy,

Hussein,

Elanwar

et al. 2024

BMC Anesthesiol

View full text Add to dashboard Cite

Background Over the last two decades, a large body of literature has focused on studying the prevalence and outcome of the postoperative delirium and sleep disturbance. The aim of this work was to evaluate the effect of intraoperative administration of Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients undergoing lumbar fixation. Methods This prospective randomized controlled trial was carried out on 80 patients indicated for lumbar fixation; 40 of them received conventional general anesthesia with extra administration of intraoperative magnesium sulphate (Mg sulphate group), and the other 40 received conventional general anesthesia only (control group). Both groups were submitted to pre-operative assessment of depression using Beck Depression inventory (BDI) scale, pre-operative assessment of fatigue using a fatigue questionnaire, pre- and post-operative assessment of insomnia using Insomnia severity index (ISI), post-operative assessment of delirium using Memorial delirium assessment scale (MDAS), post-operative assessment of pain using Visual Analogue Scale (VAS), and pre- and post-operative Quantitative electroencephalography (QEEG). Results Mg sulphate administration, age, pre-operative BDI, pre-operative ISI, and post-operative VAS were independent predictors of post-operative ISI (P-value < 0.001, 0.047, 0.021, < 0.001, and < 0.001 respectively). Age and post-operative VAS were independent predictors of post-operative MDAS (P-value = 0.008, 0.013 respectively). Mg sulphate administration and pre-operative ISI were independent predictors of post-operative VAS (P-value = 0.010, 0.006 respectively). Conclusion There was a significant relationship between intraoperative Mg sulphate administration and both post-operative insomnia and pain in unadjusted and adjusted analysis.

show abstract

The prophylactic effect of intravenous magnesium infusion on postoperative sore throat after thyroid surgery. A randomized clinical trial

Cited by 3 publications

References 0 publications

Comparison of intravenous route versus nebulization of magnesium sulfate (MgSO4) for post-operative sore throat and hoarseness: A randomized comparative double-blinded clinical trial

Comparison of intravenous route versus nebulization of magnesium sulfate (MgSO4) for post-operative sore throat and hoarseness: A randomized comparative double-blinded clinical trial

Effect of Paracetamol and Magnesium Sulfate on Level of Pain and Opioid Intake following Orthognathic Surgery: A Clinical Trial

Effect of intra-operative Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients undergoing lumbar fixation: a randomized controlled trial

Contact Info

Product

Resources

About