2004
DOI: 10.1002/lt.20075
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The prophylactic use of tranexamic acid and aprotinin in orthotopic liver transplantation: A comparative study

Abstract: The efficacy of tranexamic acid (TA) and aprotinin (AP) in reducing blood product requirements in orthotopic liver transplantation (OLT) was compared in a prospective, randomized and double-blind study. One hundred and twenty seven consecutive patients undergoing OLT were enrolled; TA was administered to 64 OLT patients at a dose of 10mg /kg/h and aprotinin was administered to 63 OLT patients at a loading dose of 2x10 6 KIU followed by an infusion of 500,000 KIU/h. The portocaval shunt could not be performed i… Show more

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Cited by 97 publications
(67 citation statements)
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“…The higher dose, Dose II, is more frequently used in liver transplant surgery, with no increase in thrombosis, reoperation or mortality in this setting. 34 General anesthesia and liver resection proceeded according to standard institutional practices with no other modifications for the purposes of this trial. Clinicians were not permitted to utilize other systemically administered antifibrinolytic agents.…”
Section: Interventionsmentioning
confidence: 99%
“…The higher dose, Dose II, is more frequently used in liver transplant surgery, with no increase in thrombosis, reoperation or mortality in this setting. 34 General anesthesia and liver resection proceeded according to standard institutional practices with no other modifications for the purposes of this trial. Clinicians were not permitted to utilize other systemically administered antifibrinolytic agents.…”
Section: Interventionsmentioning
confidence: 99%
“…Tranexamic acid infusion is employed to combat fibrinolysis and excessive bleeding. 6 We routinely the vascular anastomotic patency. Infections are common in the early postoperative period and our protocol is to remove the central intravenous catheters and abdominal drains at the earliest.…”
Section: The Recipient Surgerymentioning
confidence: 99%
“…Ensuring integrity of the blood supply to the biliary tree, transecting the bile ducts along with the hilar plate and refinement in techniques of biliary anastomosis in LDLT has resulted in a significant reduction in the incidence of biliary complications from 24.3-40.6% before 2007 to 5. [3][4][5][6][7][8][9][10][11][12].8% in studies published after 2008 (Table 6). [27][28][29][30][31][32][33][34] Overall biliary complications in LDLT in our series was seen in three recipients (16.6%) which compares well with other studies.…”
Section: Biliary Complicationsmentioning
confidence: 99%
“…Finally 7 citations [9,10,[13][14][15][16][17] , including 521 patients, were included in our study ( Figure 1). Of these 7 studies, one used tranexamic acid in the control group [16] ; two studies contained two aprotinin groups, a high dose group and a routine dose group [10,15] ; one study contained two control groups [17] ; and two studies used the same sample [10,15] , the size of which was calculated only once.…”
Section: Recording Of Datamentioning
confidence: 99%
“…Four citations, including 321 procedures, contained results on the requirement for blood products including RBCs and fresh frozen plasma (FFP) [10,14,16,17] . One of these studies contained two control groups [17] (C1 and C2); Neither aprotinin nor any other antifibrinolytic agent was used in either group, so we just took C2 as the control group.…”
Section: Effect Of Aprotinin On Rbc Requirementmentioning
confidence: 99%