The proportion of chronic kidney disease and its associated factors among adult diabetic patients at Tibebe Ghion Specialized Hospital, Bahir Dar, Ethiopia

Tesfe, Daniel; Adugna, Mesert; Nigussie, Zelalem Mehari; Woldeyohanins, Alem Endeshaw; Kifle, Zemene Demelash

doi:10.1016/j.metop.2022.100198

Cited by 4 publications

(3 citation statements)

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“…Finally, sixteen articles were used to extract the determinant factors of DN. Of these, eleven articles were retrieved for age of diabetic patients [5,9,[31][32][33][34][35][36][37][38][39] (Table 1), ten for duration of diabetic illness [5,9,15,31,32,36,[38][39][40][41] (Table 2), ten for poor glycemic control [5,9,[32][33][34]36,39,[41][42][43] (Table 3), eight for elevated systolic blood pressure [9,15,33,34,36,38,41,44] (Table 4), and twelve for co-morbid hypertension [5,15,31,33,36,[38][39]…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Determinants of diabetic nephropathy among diabetic patients in Ethiopia: Systematic review and meta-analysis

Azagew,

Beko,

Mekonnen

2024

PLoS ONE

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Introduction Diabetic nephropathy (DN) is a long-term kidney disease among diabetic patients. It is the leading cause of end-stage renal failure. In Ethiopia, DN affects the majority of diabetic populations, but there were inconsistent findings about the determinant factors across the studies. Methods We have accessed studies using PubMed, Embase, EBSCO, Web of Science, OVID, and search engines including Google and Google Scholar published up to June 2023. The study populations were diabetic patients with nephropathy. The quality of each included article was assessed using the Newcastle-Ottawa quality assessment scale. The odds ratios of risk factors were pooled using a random-effect meta-analysis model. Heterogeneity was assessed using the Cochrane Q statistics and I-Square (I2). The publication bias was detected using the funnel plot and/or Egger’s test (p< 0.05). Trim and fill analysis was carried out to treat the publication bias. The protocol has been registered with the reference number CRD42023434547. Results A total of sixteen articles were used for this reviewed study. Of which, eleven articles were used for advanced age, ten articles for duration of diabetic illness, ten articles for poor glycemic control, and eleven articles for having co-morbid hypertension. Diabetic patients with advanced age (AOR = 1.11, 95% CI: 1.03–120, I2 = 0.0%, p = 0.488), longer duration of diabetic illness (AOR = 1.23, 95% CI = 1.05–1.45, I2 = 0.0%, p = 0.567), poor glycemic control (AOR = 2.57, 95% CI: 1.07–6.14; I2 = 0.0%, p = 0.996), and having co-morbid hypertension (AOR = 4.03, 95% CI: 2.00–8.12, I2 = 0.0%, p = 0.964) were found to be factors associated with DN. Conclusions The findings of the study revealed that diabetic patients with advanced age, longer duration of diabetic illness, poor glycemic control status, and co-morbid hypertension were the determinant factors of DN. Therefore, treatment of co-morbid hypertension and high blood glucose and regular screening of renal function should be implemented to detect, treat, and reduce the progression of DN. Furthermore, healthcare workers should give due attention to diabetes with advanced age and a longer duration of diabetes illness to prevent the occurrence of DN.

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

Determinants of diabetic nephropathy among diabetic patients in Ethiopia: Systematic review and meta-analysis

Azagew,

Beko,

Mekonnen

2024

PLoS ONE

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“…Globally, more than 50% of type 2 DM patients developed CKD 9 . CKD is around 3–4 times more common in Africa than in the developed world 10 . In Ethiopia, like other developing countries, both the prevalence of DM and CKD are increasing rapidly 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

“…A systematic review of the literature conducted in 2020 shows that the prevalence of CKD among patients with DM in Ethiopia was found to be 35.52% 15 . A recent study conducted at Tibebe Ghion Specialized Hospital, Bahir Dar, shows that the prevalence of CKD was found to be 16.7% by using CKD EPI equations 10 . A study conducted in Northwest Ethiopia at the University of Gondar Hospital shows that the prevalence of CKD is 17.3% and 14.3% by the MDRD and CKD EPI equations, respectively 16 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of chronic kidney disease and its associated factors among diabetes mellitus patients in Dessie Referral Hospital, South Wollo, Ethiopia

Adem,

Mekonen,

Ausman

et al. 2024

Sci Rep

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Diabetes mellitus shares a large proportion of kidney failure. Despite many patients suffering from diabetes mellitus and its complications in Dessie City, no study was conducted in the study area that shows the prevalence and associated factors of chronic kidney disease among diabetes mellitus patients. Therefore, this study aims to assess the prevalence of chronic kidney disease and its associated factors among adult diabetes mellitus patients attending Dessie Referral Hospital, South Wollo, Northeast Ethiopia. An institutional-based cross-sectional study was conducted at Dessie Referral Hospital among 267 randomly selected adult diabetic patients. Data were collected using questionnaires administered by interviewers. The glomerular filtration rate was estimated from serum creatinine levels. Data were entered into Epi-data version 4.6 and analyzed using SPSS version 26 software. Multi-variable logistic regression was used to determine the strength of association for the associated factors of chronic kidney disease. Variables with a p value < 0.05 were used to ascertain statistically significant associations. A total of 267 diabetic patients participated in this study. About 104 (39%) of the respondents were female and from the total, 133 (48.1%) were hypertensive. The overall prevalence of chronic kidney disease in this study was 31.5% (95% CI 25.3–37.1%). Being older (p-value = 0.003) and having hypertension (p-value = 0.043) were significant factors for chronic kidney disease among diabetes mellitus patients. This study found a high prevalence (31.5%) of chronic kidney disease among diabetic patients. Older age, having hypertension, and elevated serum creatinine were statistically significant associated factors of chronic kidney disease among patients with diabetes mellitus. Thus, clinicians should be aware of the high prevalence of chronic kidney disease in Dessie City. Moreover, emphasis should be given for old age and hypertension as contributing factors to the high prevalence in diabetic patients.

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Determinants of Chronic Kidney Disease among Adult Diabetic Patients at Dessie Comprehensive Specialized Hospital,Northeast Ethiopia,2024: An institution-based case control study

Wolle,

Tsegaye,

Azene

2024

Preprint

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Background Chronic kidney disease is a condition where high blood glucose or blood pressure damages the blood vessels in the kidneys and reduces their function. It develops slowly; so many people do not realize they have it until it has reached an advanced stage. Chronic kidney disease can be prevented by controlling blood glucose and blood pressure, avoiding harmful medications, and changing lifestyle. Though prior studies were conducted on chronic kidney disease among adult diabetics in the Amhara region, possible determinant such as glycated hemoglobin level was not assessed. Objective To identify the determinants of Chronic Kidney Disease Among Adult Diabetic Patients at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia,2024. Methods We conducted institutional-based unmatched case-control study between January-1 to June-30-2024. Cases were adult diabetic patient with chronic kidney disease and controls were adult diabetic patient without chronic kidney. All cases were included while systematic random sampling was used to select controls. Data from interview, laboratory and clinical records were collected and entered into Epi info version 7.2, then exported to Statistical Package for Social Science version 27 for analysis. Multivariable binary logistic regression was used to identify determinants of chronic kidney disease and a p-value less than 0.05 was considered as statistically significant. Results A total of 95 cases and 190 controls were recruited in the study. The median (interquartile range) age of cases and controls were 62 (67 − 45) and 37.5 (61-26.75) years respectively. The study revealed that poor glycemic control (HbA1c) (AOR: 3.33, 95% CI: 1.63–6.81), age ≥ 60 years (AOR: 2.70, 95% CI: 1.36–5.37), presence of albuminuria (AOR: 4.83, 95% CI: 2.19–10.73), analgesics used (AOR: 2.43, 95% CI: 1.26–4.70), and duration of diabetes greater than or equal to 10 years (AOR: 2.52, 95% CI: 1.30–4.88) had statistically significant association with chronic kidney disease among adult diabetic patients. Conclusion The study finding indicated that poor glycemic control, older age, positive albuminuria, use of analgesics, and long duration of diabetes were significantly associated with chronic kidney disease among adult diabetic patients. We recommend that individualized glycemic target for older age and long duration of diabetic patients.

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The proportion of chronic kidney disease and its associated factors among adult diabetic patients at Tibebe Ghion Specialized Hospital, Bahir Dar, Ethiopia

Cited by 4 publications

References 18 publications

Determinants of diabetic nephropathy among diabetic patients in Ethiopia: Systematic review and meta-analysis

Determinants of diabetic nephropathy among diabetic patients in Ethiopia: Systematic review and meta-analysis

Prevalence of chronic kidney disease and its associated factors among diabetes mellitus patients in Dessie Referral Hospital, South Wollo, Ethiopia

Determinants of Chronic Kidney Disease among Adult Diabetic Patients at Dessie Comprehensive Specialized Hospital,Northeast Ethiopia,2024: An institution-based case control study

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