The Proposed Usage of Intranasal Steroids and Antihistamines for Otitis Media with Effusion

Roditi, Rachel E.; Caradonna, David S.; Shin, Jennifer J.

doi:10.1007/s11882-019-0879-x

Cited by 10 publications

(5 citation statements)

References 57 publications

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“…It may be associated with nasopharyngeal stenosis, weak self‐resistance and easy infection of respiratory diseases in young children (Kaya et al., 2017; Masna et al., 2021; Yazici et al., 2014). Previous studies (Lai et al., 2017; Roditi et al., 2019) have shown that the incidence of secretory otitis media in young children is higher than that in older children, which is consistent with the results of this study. In addition, studies (Eftekharian et al., 2012; Elicora et al., 2015; Kwon et al., 2013) have reported that the incidence of OME is the highest at the age of 3–4, with an incidence of 65%, and the lowest at the age of 13–14, with an incidence of 16.67%.…”

Section: Discussionsupporting

confidence: 93%

Otitis media with effusion in preschool children with adenoid hypertrophy: Risk factors and nursing care

Hu,

Xia,

Shi

et al. 2024

Nursing Open

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AimTo evaluate the influencing factors of otitis media with effusion (OME) in children with adenoid hypertrophy and to provide evidence for clinical treatment and care of children with adenoid hypertrophy.DesignA retrospective study.MethodsPreschool children with adenoid hypertrophy treated in our hospital from 1 January 2021 to 30 July 2022 were included. We analysed the characteristics of OME and non‐OME children with adenoid hypertrophy. Pearson correlation analysis and logistic regression analysis were performed to evaluate the risk factors for OME in children with adenoid hypertrophy.ConclusionA total of 166 children with adenoid hypertrophy were included; the incidence of OME in children with adenoid hypertrophy was 34.94%. The incidence of OME decreased significantly with the increase in age (p = 0.014). Logistic regression analysis showed that age < 3 years (OR = 3.149, 95%CI: 2.812–3.807) and duration of adenoid hypertrophy ≥12 months (OR = 2.326, 95%CI: 2.066–2.612) were the risk factors of OME in children with adenoid hypertrophy (all p < 0.05).Patient ContributionThe incidence of adenoid hypertrophy with OME is high in preschool children, and it is related to the age and duration of adenoid hypertrophy.

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Section: Discussionsupporting

confidence: 93%

Otitis media with effusion in preschool children with adenoid hypertrophy: Risk factors and nursing care

Hu,

Xia,

Shi

et al. 2024

Nursing Open

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“…Nevertheless, no differences were seen among subjects with and without allergy. Chimona et al 52 assessed the role of antihistamines in OME in an animal experimental model, but no clinical efficacy has been demonstrated for antihistamine alone or in association with topical decongestants in humans, 53 as confirmed by a meta‐analysis 54 . Hurst 55 in a prospective study investigated the effect of immunotherapy in a cohort study of patients cared for in a private community practice.…”

Section: Resultsmentioning

confidence: 99%

“…50 been demonstrated for antihistamine alone or in association with topical decongestants in humans, 53 as confirmed by a meta-analysis. 54 Hurst 55 in a prospective study investigated the effect of immunotherapy in a cohort study of patients cared for in a private community practice. We did not include this article in the qualitative analyses because author included both children and adults, the controls were not age-matched, and the cohort included mainly severe patients classified as difficult to treat middle ear diseases.…”

Section: Does Anti-allergy Treatment Prevent Middle Ear Inflammation?mentioning

confidence: 99%

Otitis media in children: Which phenotypes are most linked to allergy? A systematic review

Corso

Cantone²,

Galli

et al. 2021

Pediatric Allergy Immunology

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Background: Allergic rhinitis is a common childhood disease responsible for a major impact on quality of life and healthcare resources. Many hypotheses have been proposed to explain the link between allergy and otitis media, although a definitive mechanism has not been identified yet. One of the major critical points is that authors failed in distinguishing among different phenotypes of middle ear inflammation. This review pointed out literature evidence from the laboratory and clinical experience linking allergy to different phenotypes of otitis media in children. Methods: We performed a systematic review in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) process. Our search yielded 3010 articles that were finally screened. This resulted in 20 manuscripts of which the full texts were included in a qualitative analysis. We paid particular attention in distinguishing among phenotypes of otitis media. Results: Clinical evidence and analyses of biomarkers suggested that allergy may be linked to some phenotypes of otitis media and, in particular, to otitis media with effusion (OME) and acute re-exacerbations in children with middle ear effusion. It was not possible to perform the analysis for allergy and acute and chronic otitis media because of paucity and heterogeneity of data. Conclusion: Allergy should be considered in the diagnostic workup of children with OME as well as OME should be excluded in children with persistent moderate to severe AR. In these cases, clinicians should evaluate prompt and accurate treatment of allergy in improving outcomes, although futures studies are required to increase evidence supporting that anti-allergy treatment may be effective in the recovery and outcome of otitis media with effusion.

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“… 60 , 62 Subsequently, a meta-analysis by Roditi suggested that INCs and antihistamines were both ineffective in achieving long-term improvement in OME. 63 Therefore, antihistamines have not shown long-term benefits in either ETD or OME, and are not recommended as clinical treatment in multiple guidelines and studies. However, the emergence of second-generation antihistamines and new-generation drugs is worth further research in the future.…”

Section: Application Of Anti-allergic Therapy In the Development Of Etdmentioning

confidence: 99%

Allergy in pathogenesis of Eustachian Tube Dysfunction

Yu,

Zhang,

Zong

et al. 2024

World Allergy Organization Journal

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The Proposed Usage of Intranasal Steroids and Antihistamines for Otitis Media with Effusion

Cited by 10 publications

References 57 publications

Otitis media with effusion in preschool children with adenoid hypertrophy: Risk factors and nursing care

Otitis media with effusion in preschool children with adenoid hypertrophy: Risk factors and nursing care

Otitis media in children: Which phenotypes are most linked to allergy? A systematic review

Allergy in pathogenesis of Eustachian Tube Dysfunction

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