1957
DOI: 10.1097/00006254-195702000-00048
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The Pros and Cons of Estrogen Administration After the Menopause

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1957
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“…The sudden drop following this period was ascribed by the authors to the change from the continuous to the cyclic method of treatment. Shelton (11, 12) stated that the death rate from cancer of the genital organs and the breast was no greater in 1929 (when crystalline estrin was discovered) than in 1950. At present the consensus is that estrogenic therapy is relatively safe and that it is strictly an individual problem since there is a wide variation in the requirements during the menopausal state.…”
Section: Hormone Therapymentioning
confidence: 99%
“…The sudden drop following this period was ascribed by the authors to the change from the continuous to the cyclic method of treatment. Shelton (11, 12) stated that the death rate from cancer of the genital organs and the breast was no greater in 1929 (when crystalline estrin was discovered) than in 1950. At present the consensus is that estrogenic therapy is relatively safe and that it is strictly an individual problem since there is a wide variation in the requirements during the menopausal state.…”
Section: Hormone Therapymentioning
confidence: 99%
“…Hence, there has been some reluctance to use this hormone for continuous therapy. However, more recent work tends to dismiss the notion that either testosterone or estrogen can incite prostatic malignancy (10). Estrogen has been found to be useful in reducing neoplastic growths in the prostate and in allaying the discomforts of metastases.…”
Section: Commentmentioning
confidence: 99%