The pros and cons of prostate-specific antigen testing

Hinev, A.I.

doi:10.14748/bmr.v12.123

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…PSA is one of the most established tumor markers that is widely used in screening, diagnosis, staging, and monitoring of prostate cancer patients [ 5 , 6 ]. PSA has an established prognostic impact and is one of the three basic parameters (together with the biopsy Gleason score and the clinical stage) that is included in all preoperative prognostic tools [ 5 , 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Radical Prostatectomy as a First-Line Treatment in Patients with Initial PSA >20 ng/mL

Hinev

Anakievski

Hadjiev

2012

International Journal of Surgical Oncology

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Initial PSA >20 ng/mL is generally considered an adverse prognostic feature in prostate cancer (PCa). Our goals were to estimate the impact of radical prostatectomy (RP) on biochemical recurrence- (BCR-) free and cancer-specific survival (CSS) rates of PCa patients with PSA >20 ng/mL, and to identify patients with favorable oncological outcome. Using 20 ng/mL as a cut-point value, 205 PCa patients, who underwent RP, were stratified into two groups. Multivariate analysis was used to determine the significant outcome predictors among patients with PSA >20 ng/mL. Men in this group had significantly lower 10-yr BCR-free and CSS rates than patients with PSA ≤20 ng/mL (20.7% versus 79.6% (P < 0.001) and 65.0% versus 87.9% (P = 0.010), resp.). Pathological stage and lymph node status were found to be the only independent predictors of PSA failure. Patients with favorable combination of these variables (pT2, N0) had significantly longer 10-yr BCR-free and CSS rates (44.3% versus 0% (P = 0.001) and 100.0% versus 33.6% (P = 0.011), resp.). High PSA values do not uniformly indicate poor prognosis after surgery. Patients, who might benefit the most from RP, are those with organ confined PCa and negative lymph nodes.

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