The prospective association of Chlamydia pneumoniae and four other pathogens with development of coronary artery calcium: The Multi-Ethnic Study of Atherosclerosis (MESA)

Laek, Babray; Szklo, Moysés; McClelland, Robyn L.; Ding, Jingzhong; Tsai, Michael Y.; Bluemke, David A.; Tracy, Russell P.; Matsushita, Kunihiro

doi:10.1016/j.atherosclerosis.2013.07.053

Cited by 15 publications

(11 citation statements)

References 28 publications

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“…On the other hand, Laek et al. studied a possible correlation between positivity to infectious agents, such as C. pneumoniae , H. pylori, cytomegalovirus, herpes simplex virus, and hepatitis A virus, and coronary artery calcium (CAC) but with negative findings.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

“…Sealy-Jefferson et al [10] demonstrated that antibody levels to H. pylori predicted the incidence of strokes in a Mexican-American population (OR: 1.58; 95% CI: 1.09-2.28). On the other hand, Laek et al [11] studied a possible correlation between positivity to infectious agents, such as C. pneumoniae, H. pylori, cytomegalovirus, herpes simplex virus, and hepatitis A virus, and coronary artery calcium (CAC) but with negative findings.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

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Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. pylori may possibly play a role. Interestingly, a potential role has also been described for GI neoplastic diseases, including colorectal and pancreatic cancer. Different mechanisms of action have been proposed, ranging from the induction of a low grade inflammatory state to the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic over the last year.

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Section: Cardiovascular Diseasesmentioning

confidence: 99%

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Helicobacter pylori and Extragastric Diseases

Franceschi¹,

Tortora

Gasbarrini³

et al. 2014

Helicobacter

127

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“…A number of epidemiologic studies report a significant correlation of cardiovascular disease or its risk factors with H. pylori infection6891011. However, the results of several other studies failed to confirm the association121314.…”

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confidence: 99%

Helicobacter pylori is associated with dyslipidemia but not with other risk factors of cardiovascular disease

Kim

Lee

Kang

et al. 2016

Sci Rep

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Epidemiologic and clinical data suggest that Helicobacter pylori infection is a contributing factor in the progression of atherosclerosis. However, the specific cardiovascular disease risk factors associated with H. pylori remain unclear. We performed a cross-sectional study of 37,263 consecutive healthy subjects who underwent a routine health check-up. In multivariable log Poisson regression models adjusted for potential confounders, the associations of H. pylori seropositivity with higher LDL-C (relative risk [RR], 1.21; 95% confidence interval [CI], 1.12–1.30) and lower HDL-C level (RR, 1.10; 95% CI, 1.01–1.18) were significant and independent. In multiple linear regression analyses, H. pylori infection was significantly associated with higher total cholesterol level (coefficient = 2.114, P < 0.001), higher LDL-C level (coefficient = 3.339, P < 0.001), lower HDL-C level (coefficient = −1.237, P < 0.001), and higher diastolic blood pressure (coefficient = 0.539, P = 0.001). In contrast, H. pylori infection was not associated with obesity-related parameters (body mass index, waist circumference), glucose tolerance (fasting glucose, glycated hemoglobin), and systolic blood pressure. We found that H. pylori infection was significantly and independently associated with dyslipidemia, but not with other cardiometabolic risk factors, after adjusting for potential risk factors of atherosclerosis.

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“…However, contrary to the results of the clinical studies and a recent meta-analysis that suggested a closer relationship between the HP infection and the risk and outcomes of AMI and ACS, 2 data about a link between HP infection and chronic CAD are inconsistent. 4 – 13 …”

Section: Discussionmentioning

confidence: 99%

“… 2 At the same time, data regarding a link between HP infection and chronic CAD are inconsistent. 4 – 13 Therefore, we aimed to test a correlation between HP infection and the severity of coronary atherosclerosis in patients with chronic CAD. Assuming that HP infection represents an independent CAD risk factor, more severe coronary atherosclerosis was expected in HP-positive patients.…”

Section: Introductionmentioning

confidence: 99%

<em>Helicobacter pylori </em>infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease

Jukić

Božić

Kardum

et al. 2017

TCRM

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AimControversy exists concerning the relation between Helicobacter pylori (HP) infection and coronary artery disease (CAD). We aimed to examine the relationship between HP infection and severity of coronary atherosclerosis in patients with chronic CAD.Patients and methodsA total of 150 patients (109 [73%] men; mean age 62.61±10.23 years) scheduled for coronary artery bypass grafting surgery were consecutively enrolled in the cross-sectional study. According to rapid urease test and/or gastric biopsy samples stained with hematoxylin and eosin and according to Giemsa, patients were classified as HP positive (n=87; 58%) or HP negative (n=63; 42%). Coronary angiograms were scored by quantitative assessment, using multiple angiographic scoring system: 1) vessel score (number of coronary arteries stenosed ≥50%), 2) Gensini score (assigning a severity score to each coronary stenosis according to the degree of luminal narrowing and its topographic importance) and 3) angiographic severity score (number of coronary artery segments stenosed ≥50%).ResultsIn comparison to HP-negative patients, HP-positive patients were more frequently hypertensive (P=0.014), had higher values of systolic (P=0.043) and diastolic (P=0.005) blood pressure and total cholesterol (P=0.013) and had lower values of high-density lipoprotein-cholesterol (HDL-C; P=0.010). There were no significant differences between the groups in the severity of coronary atherosclerosis: vessel score (P=0.152), Gensini score (P=0.870) and angiographic severity score (P=0.734).ConclusionIt is likely that HP infection is not a risk factor for the severity of coronary atherosclerosis in chronic CAD patients.

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The prospective association of Chlamydia pneumoniae and four other pathogens with development of coronary artery calcium: The Multi-Ethnic Study of Atherosclerosis (MESA)

Cited by 15 publications

References 28 publications

Helicobacter pylori and Extragastric Diseases

Helicobacter pylori and Extragastric Diseases

Helicobacter pylori is associated with dyslipidemia but not with other risk factors of cardiovascular disease

<em>Helicobacter pylori </em>infection and severity of coronary atherosclerosis in patients with chronic coronary artery disease

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