The Protean Manifestations of Mycoplasma Pneumoniae Infection in Adults

Murray, Henry W.; Masur, Henry; Senterfit, Laurence B.; Roberts, Richard B.

doi:10.1097/00006254-197508000-00012

Cited by 25 publications

(34 citation statements)

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“…Up to one-third of patients with M. pneumoniae infection may have nonspecific ear symptoms, including otitis externa, otitis media, and myringitis (301,392). Acute rhabdomyolysis was recently reported in association with M. pneumoniae infection in a 15-year-old patient (41).…”

Section: Extrapulmonary Manifestationsmentioning

confidence: 99%

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

2004

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Mycoplasma pneumoniae is a unique bacterium that does not always receive the attention it merits considering the number of illnesses it causes and the degree of morbidity associated with it in both children and adults. Serious infections requiring hospitalization, while rare, occur in both adults and children and may involve multiple organ systems. The severity of disease appears to be related to the degree to which the host immune response reacts to the infection. Extrapulmonary complications involving all of the major organ systems can occur in association with M. pneumoniae infection as a result of direct invasion and/or autoimmune response. The extrapulmonary manifestations are sometimes of greater severity and clinical importance than the primary respiratory infection. Evidence for this organism's contributory role in chronic lung conditions such as asthma is accumulating. Effective management of M. pneumoniae infections can usually be achieved with macrolides, tetracyclines, or fluoroquinolones. As more is learned about the pathogenesis and immune response elicited by M. pneumoniae, improvement in methods for diagnosis and prevention of disease due to this organism may occur

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Section: Extrapulmonary Manifestationsmentioning

confidence: 99%

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

2004

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“…It is the most common cause of primary atypical pneumonia resistant to ␤-lactam antibiotics in older children and young adults (5,10,15). M. pneumoniae can also be associated with severe extrapulmonary complications (9,21,24). The standard laboratory methods for the specific diagnosis of M. pneumoniae infection have been isolation in culture and serological methods.…”

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confidence: 99%

Evaluation of Four Commercial Immunoglobulin G (IgG)- and IgM-Specific Enzyme Immunoassays for Diagnosis of Mycoplasma pneumoniae Infections

Petitjean¹,

Vabret²,

Gouarin³

et al. 2002

J Clin Microbiol

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routine diagnosis. A good concordance of IgG seroprevalence in healthy adults was found between the four EIAs (66 to 70%), though this concordance was lower with EIA-Platelia (43%). In healthy children, EIA-BMD and EIA-Biotest gave a higher IgG seroprevalence than EIA-Sorin and EIA-Platelia (45% each for the former compared to 17 and 20%, respectively, for the latter). These results confirm that the IgM EIA serology test is a valuable tool for the early diagnosis of M. pneumoniae infections in children, as long as the EIA used is specific. In adults, the difficult interpretation of EIAs suggests that paired sera, combined with PCR detection on respiratory tract specimens collected on admission of patient, should be required for accurate diagnosis.Mycoplasma pneumoniae is a common respiratory pathogen responsible for mild acute respiratory infections such as sore throats, pharyngitis, and tracheobronchitis in younger children. It is the most common cause of primary atypical pneumonia resistant to ␤-lactam antibiotics in older children and young adults (5,10,15). M. pneumoniae can also be associated with severe extrapulmonary complications (9, 21, 24). The standard laboratory methods for the specific diagnosis of M. pneumoniae infection have been isolation in culture and serological methods. Culture is time-consuming and relatively insensitive. The conventional complement fixation test (CFT) using a glycolipid antigen gives unspecific reactions and lacks sensitivity (16,19). Alternative tests have recently been developed to obtain moreaccurate and prompt diagnosis: indirect enzyme immunoassay (EIA) measuring separately immunoglobulin G (IgG) and IgM class antibodies (8,14,27,33,35) and PCR for rapid and sensitive detection of M. pneumoniae in respiratory tract specimens (1,4,6,31,32,36). The objective of this retrospective study was to compare the performance of four commercially available EIAs for the detection of specific M. pneumoniae IgG and IgM antibodies in assessing the antibody response of suspected M. pneumoniae patients on the basis of PCR-positive results for M. pneumoniae in respiratory samples. Furthermore, we evaluated the ability of the serological tests to accurately establish an earlier serodiagnosis of M. pneumoniae infections. MATERIALS AND METHODSPatients and controls. For a 4-year period, January 1997 through December 2000, 39 patients (group I: 27 children and 12 adults), admitted to Caen's hospital with clinical features of upper or lower respiratory tract infection consistent with M. pneumoniae infection, were retrospectively selected on the basis of a specific M. pneumoniae-positive PCR in respiratory tract samples. Serum specimens and respiratory tract specimens were obtained on admission from all 39 patients. In addition, serum specimens were obtained 5 to 22 days later from 13 patients. Upon their receipt, the 52 serum samples were serologically investigated for M. pneumonia-specific IgM and IgG antibodies by the Platelia EIAs IgG and IgM (Diagnostica Pasteur Sanofi) (referred to herein...

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“…Hyperbilirubinemia usually occurs as the indirect type, mostly because of hemolysis in mycoplasma infections. In contrast, adults with M. pneumoniae infection have demonstrated a hepatocellular pattern of liver enzymes without jaundice [14][15][16][17].…”

Section: Pneumoniae-associated Acute Hepatitis Without Pneumoniamentioning

confidence: 99%

“…Some bacterial infections are often associated with acute hepatitis, such as Salmonella, Rickettsia, Brucella or M. pneumonia [14]. Hepatitis due to M. pneumoniae was first described in 1975 [15]. Selected cases of M. pneumoniae-associated acute hepatitis were retrieved from MEDLINE and are summarized in Table 1 [9,14,16,17].…”

Section: Pneumoniae-associated Acute Hepatitis Without Pneumoniamentioning

confidence: 99%

Review Article: Mycoplasma Pneumoniae-Associated Acute Hepatitis

Lee¹

2017

GHOA

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Mycoplasma pneumoniae is a major cause of respiratory infections and a possible etiology of acute hepatitis. Acute hepatitis due to M. pneumoniae infection is often combined with presentation of pneumonia, even without lung involvement. The presentations and etiologies of M. pneumoniae-associated hepatitis with simultaneous, delayed, or without, lung involvement are different, and should be discussed separately. The most widely available and effective drug of treatment is macrolides, and its clinical outcome is extremely good.

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The Protean Manifestations of Mycoplasma Pneumoniae Infection in Adults

Cited by 25 publications

References 0 publications

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

Mycoplasma pneumoniaeand Its Role as a Human Pathogen

Evaluation of Four Commercial Immunoglobulin G (IgG)- and IgM-Specific Enzyme Immunoassays for Diagnosis of Mycoplasma pneumoniae Infections

Review Article: Mycoplasma Pneumoniae-Associated Acute Hepatitis

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