2009
DOI: 10.1016/j.mam.2009.04.001
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The proteasomal system

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Cited by 366 publications
(340 citation statements)
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References 1,379 publications
(1,193 reference statements)
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“…The 20S proteasome plays a key role in the degradation of oxidatively damaged proteins that are not ubiquitin-tagged (Reinheckel et al 1998;Davies 2001). Conversely, ubiquitin-tagged proteins are degraded by the 26S proteasome (Jung et al 2009). To estimate the capacity for degrading ubiquitintagged proteins, 26S proteasome activity was measured in liver and brain tissue samples, generating similar results to 20S proteasome activity.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The 20S proteasome plays a key role in the degradation of oxidatively damaged proteins that are not ubiquitin-tagged (Reinheckel et al 1998;Davies 2001). Conversely, ubiquitin-tagged proteins are degraded by the 26S proteasome (Jung et al 2009). To estimate the capacity for degrading ubiquitintagged proteins, 26S proteasome activity was measured in liver and brain tissue samples, generating similar results to 20S proteasome activity.…”
Section: Resultsmentioning
confidence: 99%
“…The 20S/26S proteasome is a multi-subunit proteolytic complex found in the cytosol and nucleus that performs this task. The 20S proteasome degrades oxidatively damaged proteins (Reinheckel et al 1998;Davies 2001), whereas the 26S proteasome, which is composed of the core 20S barrel with regulatory cap regions on either end, recognizes and degrades ubiquitin-tagged proteins that may or may not be damaged (Jung et al 2009). In addition to a global role in damaged protein degradation, the nuclear 26S proteasome also degrades ubiquitylated RNA polymerase II associated with transcriptional arrest at sites of DNA damage (Daulney and Tansey 2009) and ubiquitin-tagged apoptotic proteins, thus preventing cell death (Bader and Steller 2009).…”
mentioning
confidence: 99%
“…In contrast to the 20S proteasome, the 26S proteasome degrades substrate proteins in an ATP-dependent way and it requires a polyubiquitin sequence to recognize the substrate proteins. Due to the involvement of the ubiquitintargeting machinery in degradation of 26S substrate proteins, this system is also referred to as the ubiquitin-proteasome system (UPS) (81,96). The 19S regulator (also known as PA700) consists of some 19 monomers (Rpt-and Rpnsubunits).…”
Section: Repair and Degradation Of Oxidized Proteinsmentioning
confidence: 99%
“…No entanto, quando há uma quantidade maior de oxidantes em relação aos antioxidantes, o organismo fica vulnerável aos efeitos deletérios das espécies reativas e a inúmeros distúrbios metabólicos e fisiológicos. A essa condição dá-se o nome de estresse oxidativo [15][16][17][18][19][20].…”
Section: Estresse Oxidativo Síndrome Metabólica E Alterações Vascularesunclassified