The protective antioxidant activity of ginger extracts (Zingiber Officinale) in acute kidney injury: A systematic review and meta-analysis of animal studies

Rostamkhani, Helya; Faghfouri, Amir Hossein; Veisi, Parisa; Rahmani, Alireza; Noshadi, Nooshin; Ghoreishi, Zohreh

doi:10.1016/j.jff.2022.105111

Cited by 9 publications

(6 citation statements)

References 47 publications

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“…In young, adult, and old ginger-treated rats, ginger increased catalase’s catalytic activity, while we noticed decreased SOD activity in the old rats. This was consistent with earlier research that reported ginger extract has potent antioxidant activities and can serve a similar purpose as antioxidant enzymes including catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) ( Rostamkhani et al, 2022 ). Ginger’s anti-inflammatory characteristics benefited type 2 diabetics with insulin resistance by improving glucose tolerance and uptake in the body, which led to a reduction in insulin resistance ( Pakan et al, 2021 ).…”

Section: Discussionsupporting

confidence: 93%

A subcritical water extract of soil grown Zingiber officinale Roscoe: Comparative analysis of antioxidant and anti-inflammatory effects and evaluation of bioactive metabolites

et al. 2023

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Introduction: Ginger (Zingiber officinale Roscoe) can scavenge free radicals, which cause oxidative damage and inflamm-ageing. This study aimed to evaluate the antioxidant and anti-inflammatory effects of soil ginger's sub-critical water extracts (SWE) on different ages of Sprague Dawley (SD) rats. The antioxidant properties and yield of SWE of soil- and soilless-grown ginger (soil ginger and soilless ginger will be used throughout the passage) were compared and evaluated.Methods: Three (young), nine (adult), and twenty-one (old) months old SD rats were subjected to oral gavage treatments with either distilled water or the SWE of soil ginger at a concentration of 200 mg/kg body weight (BW) for three months.Results: Soil ginger was found to yield 46% more extract than soilless ginger. While [6]-shogaol was more prevalent in soilless ginger, and [6]-gingerol concentration was higher in soil ginger (p < 0.05). Interestingly, soil ginger exhibited higher antioxidant activities than soilless ginger by using 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assay. With ginger treatment, a reduced levels of tumour necrosis factor-α (TNF-α) and C-reactive protein (CRP) but not interleukin-6 (IL-6) were observed in young rats. In all ages of SD rats, ginger treatment boosted catalase activity while lowering malondialdehyde (MDA). Reduction of urine 15-isoprostane F2t in young rats, creatine kinase-MM (CK-MM) in adult and old rats and lipid peroxidation (LPO) in young and adult rats were also observed.Discussion: The findings confirmed that the SWE of both soil and soilless grown ginger possessed antioxidant activities. Soil ginger produced a higher yield of extracts with a more prominent antioxidant activity. The SWE of soil ginger treatment on the different ages of SD rats ameliorates oxidative stress and inflammation responses. This could serve as the basis for developing a nutraceutical that can be used as a therapeutic intervention for ageing-related diseases.

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Section: Discussionsupporting

confidence: 93%

A subcritical water extract of soil grown Zingiber officinale Roscoe: Comparative analysis of antioxidant and anti-inflammatory effects and evaluation of bioactive metabolites

et al. 2023

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“…O uso dos extratos herbais na alimentação animal tem sido cada vez mais difundido, evidenciando que os compostos presentes em sua composição podem apresentar benefícios à produção de animais não ruminantes (Pasquali & Pimenta, 2014). Alguns dos efeitos relatados pela literatura são: melhoria do desempenho e imunidade animal, ação antioxidante (Bozkurt et al, 2009;Farahat et al, 2021;SUN et al, 2021;Ghafarifarsani et al, 2022;Rostamkhani et al, 2022), atuação antimicrobiana (BOZKURT et al, 2009), melhora na saúde intestinal (Farahat et al, 2021), ação sobre a mucosa intestinal (Fernandes et al, 2017;Bona et al, 2012), entre outras.…”

Section: Extratos Herbaisunclassified

Potencial de utilização de extratos vegetais como aditivo natural para melhoria da qualidade de ovos – revisão

Ferreira,

Lopes,

Souza

et al. 2024

Braz. J. Anim. Environ. Res.

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Os extratos vegetais são aditivos fitogênicos oriundos de plantas que produzem metabólitos secundários ricos em compostos fenólicos e polifenólicos (fenóis simples e ácidos fenólicos, quinonas, flavonas, taninos), terpenos, alcalóides, lectinas e polipeptídios. Esses compostos apresentam ação antioxidante, antimicrobiana, de melhoria na saúde intestinal e aumento da absorção e digestão de nutrientes. Desta forma, tornam-se alternativas aos aditivos sintéticos comumente utilizados na avicultura com o diferencial de ser um produto natural que não gera resíduos. O potencial antimicrobiano dos extratos acontece devido seu caráter hidrofóbico, que penetra a membrana celular bacteriana causando sua ruptura e morte, sendo assim, são capazes de modular a microbiota intestinal de galinhas poedeiras, melhorando o aproveitamento das dietas e, consequentemente, a produção e qualidade dos ovos. A presença dos polifenóis nos extratos herbais pode promover atividade antioxidante sobre os ovos produzidos, melhorando qualidade e possivelmente aumentando sua vida de prateleira. O uso desses extratos herbais na nutrição avícola tem sido cada vez mais difundido, entretanto, existem mais pesquisas desenvolvidas com frangos de corte do que com aves de postura. Com isso, este trabalho de revisão tem como objetivo apresentar os mecanismos de atuação, as principais plantas utilizadas e as vantagens do uso dos extratos herbais na avicultura de postura.

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“…These compounds function to promote enzyme action, maintain blood circulation, and enhance general physical wellbeing. 40 The health benefits of emprit ginger, or Zingiber oficinale, include enhanced endogenous antioxidant enzymes, 41 xanthine oxidase inhibition, 42 anti-inflammatory effects, 43 antimicrobial activity against a number of pathogenic microorganisms and acting as a chemopreventive agent against carcinogens. 44 The major bioactive phytochemicals in the plants are phenolic substances like shogaol and gingerol which are known for their antioxidant activity.…”

Section: Curcuma Longa L (Turmeric)mentioning

confidence: 99%

Zingiberaceae Rhizome as Traditional Medicine Based on Dayak Linoh, Malay, and Javanese Local Wisdom

2024

TJNPR

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Zingiberaceae rhizomes have been used in the traditional medicine practices of three ethnic groups; Dayak Linoh, Malay, and Javanese, of the Sintang Regency, West Kalimantan, Indonesia for generations. Althogh, it has been around for a long time, the culture of herbal medicine and knowledge about using Zingiberaceae rhizomes as traditional medicine is still not well documented. This research aims to identify, document, and determine the types, methods of processing, and use of Zingiberaceae rhizomes as traditional medicine. The research methodology was an ethnobotanical survey involving participant observation and interviews with informants in the three tribal communities. The research results showed that the three tribal communities use thirteen (13) species of Zingiberaceae rhizomes as herbal medicine. The most commonly used Zingiberaceae rhizomes were the rhizomes of K. galanga, C. longa, Z. officinale, A. galanga, Z. cassumunar, and C. zedoria, each with a percentage use of 11.54%. The most widely used methods of processing these Zingiberaceae rhizomes were by grinding and boiling. The most widely used mode of application of the Zingiberaceae rhizomes as a traditional medicine was by drinking. Fifteen diseases were reported to be treated using Zingiberaceae rhizomes in these tribal communities. The findings from this study indicated that the three tribal communities studied use the same types of Zingiberaceae rhizomes in their traditional medicine practices, but differ in their method of processing and mode of application of these plants.

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The protective antioxidant activity of ginger extracts (Zingiber Officinale) in acute kidney injury: A systematic review and meta-analysis of animal studies

Cited by 9 publications

References 47 publications

A subcritical water extract of soil grown Zingiber officinale Roscoe: Comparative analysis of antioxidant and anti-inflammatory effects and evaluation of bioactive metabolites

A subcritical water extract of soil grown Zingiber officinale Roscoe: Comparative analysis of antioxidant and anti-inflammatory effects and evaluation of bioactive metabolites

Potencial de utilização de extratos vegetais como aditivo natural para melhoria da qualidade de ovos – revisão

Zingiberaceae Rhizome as Traditional Medicine Based on Dayak Linoh, Malay, and Javanese Local Wisdom

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