The protective effect of adrenocorticotropic hormone treatment against noise-induced hearing loss

Mutlu, Ahmet; Öçal, Fatma Ceyda Akın; Erbek, Seyra; Özlüoğlu, Levent N.

doi:10.1016/j.anl.2017.12.006

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…The use of ACTH analogs in noise-exposed rats reports significantly better results on ABR thresholds than the control group due to their anti-inflammatory effects. This anti-inflammatory effect would be explained by direct inhibition through their MC1, MC3, and MC5 receptors on several inflammatory cells, while stimulating their down-mediators, aldosterone, and corticosteroids [58], but also because they induce the expression of mineralocorticoid receptors in the SV and other cochlear structures [59]. In fact, aldosterone has interesting effects on hearing.…”

Section: Acthmentioning

confidence: 99%

Hormone Therapy: Challenges for Treating Hearing Impairments

Guerra¹,

Devesa²

2019

SN Compr. Clin. Med.

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The purpose of this review is to summarize the advances and discoveries in the potential treatment with hormone analogs and some challenges still pending, beyond the classic treatment with corticosteroids. We conduct a review of the functions of hormones on hearing, in human and animal models, the presence of their most relevant receptors, and the desirable and undesirable effects for their therapeutic uses. Different hormones play a regulatory role in the development and maintenance of hearing. Hormone receptors in the ear have been identified over the years, which can be a support to use them as new therapeutic targets Moreover, their mediators, that include cells, neurotrophic factors, or other hormones, could be also useful for treating various hearing impairments The use of synthetic analogs could exert a therapeutic effect on hearing. Hormone therapy, in fact, can contribute positively to the treatment and prevention of various auditory pathologies, through the regeneration or protection. Considering that an optimal result has to be a garantee, it is a must to know their unwanted effects and contraindications. The use of hormones may protect, regenerate, and modulate multiple pathological conditions of the ear, but it would be necessary to standardize drug dosages, find alternative routes, and conduct prospective studies in humans.

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Section: Acthmentioning

confidence: 99%

Hormone Therapy: Challenges for Treating Hearing Impairments

Guerra¹,

Devesa²

2019

SN Compr. Clin. Med.

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“…A recent study on manufacturing workers has shown that the mean prevalence of high-frequency NIHL is 41.64% [4]. Although current research on NIHL drug therapy includes anti-inflammatory (such as dexamethasone [5], methylprednisolone [6], and curcumin [7]), antioxidant (such as resveratrol [8] and salicylate Trolox [9]), and antiapoptotic drugs (such as all-trans retinoic acid [10] and AM-111 [11]), there are no specific drugs for NIHL [1]. In clinical practice, hearing aids [12] and cochlear implants [13] are generally supportive treatments for permanent hearing loss, but the patients can neither fundamentally repair damaged or missing hair cells (HCs), nor they can achieve complete reconstruction of hearing function.…”

Section: Introductionmentioning

confidence: 99%

Effects of Astragaloside IV on Hearing, Inflammatory Factors, and Intestinal Flora in Mice Exposed to Noise

Li,

Yang,

Xia

et al. 2024

Metabolites

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Long-term exposure to noise can cause irreversible hearing loss. Considering that there is no effective drug treatment, it is important to seek preventive treatment for noise-induced hearing loss (NIHL). Although astragaloside IV (AS-IV) protects against NIHL by reducing serum inflammatory factors, there is scarce information on the regulation of inflammatory factors by AS-IV to prevent NIHL. We investigated the hearing thresholds and relationship between the serum levels of inflammatory cytokines and intestinal microbiota of c57bl/6j mice exposed to noise (103 dB SPL 4 h·d−1) for 7 days, treated with or without AS-IV. Our results revealed a lower hearing threshold and lower serum levels of TNF-α, TNF-γ, IL-6, IL-1β, and IFN-γ in the mice treated with AS-IV. Additionally, AS-IV increased the abundance levels of the phylum Firmicutes, class Bacillus, order Lactobacillus, and family Lactobacillus (p < 0.05), and decreased those of the phylum Bacteroidetes and order Bacteroidales (p < 0.05). Lactobacillus and Bacilli negatively correlated with TNF-α, TNF-γ, and IL-1β; Erysipelotrichaceae negatively correlated with INF-γ; and Clostridiales positively correlated with IL-1β. In conclusion, AS-IV reduces the elevation of hearing thresholds in mice, preventing hearing loss in mice exposed to noise, and under the intervention of AS-IV, changes in the levels of inflammatory factors correlate with intestinal flora. We suggest that AS-IV improves intestinal flora and reduces inflammation levels in c57bl/6j mice exposed to noise.

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