The protective effect of Angiotensin AT2-receptor stimulation in Neuromyelitis optica spectrum disorder is independent of astrocyte-derived BDNF

Khorooshi, Reza; Marczynska, Joanna; Dubik, Magdalena; Dieu, Ruthe; Sørensen, Sofie Forsberg; Montanana-Rosell, Roser; Limburg, Hannah Liska; Tygesen, Camilla; Asgari, Nasrin; Steckelings, Ulrike Muscha; Owens, Trevor

doi:10.1016/j.msard.2021.103033

Cited by 2 publications

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“…However, since the therapeutic effect of AT 2 R-stimulation with C21 was preserved in mice with astrocyte-specific, conditional knockout of BDNF, a causal involvement of BDNF in the protective effect of C21 could not be proven. It is possible, however, that neuronal BDNF, which was not affected by the knockout, was responsible for the protective effect (Khorooshi et al, 2021).…”

Section: E Lungmentioning

confidence: 99%

The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target

et al. 2022

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NF-jB to enter the nucleus and initiate transcription. Collectively, these events lead to reduced synthesis of proinflammatory cytokines and of cyclooxygenase 2 (COX-2), the enzyme that mediates synthesis of proinflammatory prostaglandins.Key Points related to Section III.C on intracellular signaling are:• The intracellular signaling pathways coupled to this atypical GPCR are equally atypical and very different from the canonical GPCR-mediated signaling events.

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Section: E Lungmentioning

confidence: 99%

The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target

et al. 2022

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The impact of physical exercise on neuroinflammation mechanism in Alzheimer’s disease

Hu,

Huang,

Chen

2024

Front. Aging Neurosci.

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IntroductionAlzheimer’s disease (AD), a major cause of dementia globally, imposes significant societal and personal costs. This review explores the efficacy of physical exercise as a non-pharmacological intervention to mitigate the impacts of AD.MethodsThis review draws on recent studies that investigate the effects of physical exercise on neuroinflammation and neuronal enhancement in individuals with AD.ResultsConsistent physical exercise alters neuroinflammatory pathways, enhances cognitive functions, and bolsters brain health among AD patients. It favorably influences the activation states of microglia and astrocytes, fortifies the integrity of the blood-brain barrier, and attenuates gut inflammation associated with AD. These changes are associated with substantial improvements in cognitive performance and brain health indicators.DiscussionThe findings underscore the potential of integrating physical exercise into comprehensive AD management strategies. Emphasizing the necessity for further research, this review advocates for the refinement of exercise regimens to maximize their enduring benefits in decelerating the progression of AD.

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The protective effect of Angiotensin AT2-receptor stimulation in Neuromyelitis optica spectrum disorder is independent of astrocyte-derived BDNF

Abstract: The protective effect of Angiotensin AT2-receptor stimulation in Neuromyelitis optica spectrum disorder is independent of astrocyte-derived BDNF, Multiple Sclerosis and Related Disorders (2021), doi:

Cited by 2 publications

References 16 publications

The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target

The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target

The impact of physical exercise on neuroinflammation mechanism in Alzheimer’s disease

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The protective effect of Angiotensin AT2-receptor stimulation in Neuromyelitis optica spectrum disorder is independent of astrocyte-derived BDNF

Abstract: The protective effect of Angiotensin AT2-receptor stimulation in Neuromyelitis optica spectrum disorder is independent of astrocyte-derived BDNF, Multiple Sclerosis and Related Disorders (2021), doi:

Cited by 2 publications

References 16 publications

The Angiotensin AT2Receptor: From a Binding Site to a Novel Therapeutic Target

The Angiotensin AT2Receptor: From a Binding Site to a Novel Therapeutic Target

The impact of physical exercise on neuroinflammation mechanism in Alzheimer’s disease

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Product

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The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target

The Angiotensin AT₂Receptor: From a Binding Site to a Novel Therapeutic Target