The protective effect of Azadirachta excelsa leaves extract and quercetin treatment on the learning and memory impairments in relation with insulin and amylin levels in the brain of streptozotocin-induced diabetic rats

Zin, Noor Syaffinaz Noor Mohamad; Samsulrizal, Nurdiana; Azmi, Nur Syimal ain

doi:10.1016/j.jksus.2018.05.017

Cited by 8 publications

(2 citation statements)

References 44 publications

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“…The architecture of the pancreatic tissue correlates with the stage of diabetes and its severity (29). In the current study after STZ injection, diabetic rats showed damage to the pancreatic islet cells and severe pathological changes to exocrine and endocrine components, which is consistent with previous findings (30). Rats treated with fenugreek, showed protection of pancreatic tissues, possibly due to the presence of diosgenin which is postulated to have several antidiabetic effects, such as the regeneration of pancreatic β-cells and enhancement of insulin secretion in general (1,31).…”

Section: Discussionsupporting

confidence: 92%

Anti-diabetic effects of fenugreek (Trigonella foenum-graecum): A comparison between oral and intraperitoneal administration - an animal study

et al. 2020

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Herbal medicine is used by millions of diabetic patients due to economic and cultural factors. The current study investigates the antidiabetic potential of fenugreek (Trigonella foenum-graecum) seed extract at a dose of 100 mg/kg in a Streptozocin-induced diabetic model. Male Sprague-Dawley rats received either intraperitoneal fenugreek [daily (ED) or every other day (EOD)] or oral fenugreek supplement daily, for four weeks. Results show that fenugreek significantly reduced blood glucose. Urea levels were reduced after daily intraperitoneal injection, and creatinine levels dropped after oral treatment, respectively. AST and ALT levels were reduced following fenugreek treatment, while protein levels significantly increased. High-density lipoprotein (HDL) increased after daily injections, while triglycerides decreased significantly in all groups. Glutathione S-transferase and catalase increased with treatment, while peroxidase antioxidant enzyme levels were reduced. Glutathione peroxidase levels increased only after daily injection. Histologically, fenugreek mildly protected hepatic, renal, and pancreatic tissues. In conclusion, the current study shows some potential benefits of fenugreek use. Oral and injectable fenugreek showed improvement in blood glucose, renal and liver functions. Although triglyceride levels decreased significantly, no significant changes in cholesterol levels were seen after fenugreek use. Higher doses and longer fenugreek treatment duration are recommended for the optimum protection of the liver, kidneys, and pancreatic tissues.

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Section: Discussionsupporting

confidence: 92%

Anti-diabetic effects of fenugreek (Trigonella foenum-graecum): A comparison between oral and intraperitoneal administration - an animal study

et al. 2020

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“…After 1 week, the blood glucose levels were estimated from the animal tail with a digital blood glucose meter (Gluco-Dr). Animals with diabetes are characterized by fasting blood glucose (FBG) exceeding 11 mMol/l ( Zin et al ., 2019 ; Onyibe et al ., 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Titisari,

Fauzi,

Razak

et al. 2023

Open Vet J

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Background: Fish oil, which is regarded as the primary source of omega-3 fatty acids, has been long studied for its potential as an antidiabetic therapy. However, its protective ability against insulin resistance and pancreatic islet alteration remains unclear and controversial. Aim: To investigate the beneficial effects of fish oil consumption on the progression of insulin resistance and pancreatic islet dysfunction in a rat model of diabetes. Methods: Diabetic rats model (n=30) were divided into 5 groups and received; 1) NS injection+NS oral (NC); 2) NS injection+3g/kg fish oil (FC); 3) STZ injection+NS oral (DC); 4) STZ injection+1g/kg fish oil (DFO1) and 5) STZ injection+3g/kg fish oil (DFO3). Fasting blood insulin was analyzed by commercial rat insulin ELISA assay; meanwhile, the determination of insulin sensitivity was calculated by HOMA-IR and HOMA-B. A histological study was conducted on pancreas tissue using H & E staining. Results: Fish oil supplementation reduced hyperglycemia and ameliorated HOMA IR in STZ-induced animal models indicating that fish oil supplementation improved insulin sensitivity. Furthermore, animals treated with fish oil at a dose of 3g/kg (DFO3) showed an enhancement in pancreatic islets, which was displayed by less abnormal structures than diabetic control animals (DC). This could imply that the administration of fish oil, especially rich in bioactive omega-3 fatty acids effectively inhibits insulin resistance and restore islet of Langerhans alteration in rats injected with STZ. Conclusion: Thus, the current study suggested that fish oil supplementation could support the treatment of diabetes but should not be considered as an alternative therapy.

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Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

Khazaei

Pesce

Patruno

et al. 2020

Phytotherapy Research

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Diabetes mellitus is a metabolic defect with many complications for the patients. Deaths due to diabetes and its complications are increasing, and one of the most serious consequences are the neurological disorders. Chemical treatments have irreversible side effect and therefore the aim of this study is to evaluate the medicinal plants used for treatment of cognitive impairments and neurodegenerative diseases associated with diabetes in 2004–2020 period. Electronic databases used were PubMed, Scopus and Cochrane library. The keywords used were “diabetes,” “plant,” “herb,” “neurodegenerative,” “neurodegeneration,” “cognitive,” “cognition,” “Alzheimer,” “dementia.” The non‐English articles, repetitive articles and review studies were excluded. From total of 3,590 results, 58 articles are included in the study. The results show that many chemical treatments considered for this disease simply control hyperglycemia, but cannot improve the complications of diabetes. Herbal medicine could be more effective due to the high antioxidant activity of some medicinal plants. Biologically active substances of medicinal plants can improve the neurological disorders caused by diabetes via several pathways. The most important pathway is related to antioxidant properties. Other pathways include antiinflammatory, anti‐apoptotic, neurotoxicity inhibition, neuronal death, increasing the uptake of glucose by cells and improve neurotransmitters levels involved in learning and memory.

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The protective effect of Azadirachta excelsa leaves extract and quercetin treatment on the learning and memory impairments in relation with insulin and amylin levels in the brain of streptozotocin-induced diabetic rats

Cited by 8 publications

References 44 publications

Anti-diabetic effects of fenugreek (Trigonella foenum-graecum): A comparison between oral and intraperitoneal administration - an animal study

Anti-diabetic effects of fenugreek (Trigonella foenum-graecum): A comparison between oral and intraperitoneal administration - an animal study

Protective potential of fish oil supplementation against insulin resistance and pancreatic islet damage in STZ-induced Wistar rats

Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

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