The protective effect of bee venom against verapamil embryotoxicity during prenatal liver and kidney development of mice Mus musculus

Seleem, Amin A.

doi:10.1016/j.jobaz.2016.03.001

Cited by 2 publications

(1 citation statement)

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“…SCN1A plays a critical role during neuronal excitability including the initiation and propagation of action potentials (Lai and Jan, 2006); therefore, the genes of this channel are considered important causative agents in epilepsy (Trimmer and Rhodes, 2004). In addition to Lorincz and Nusser (2010) revealing that dendritic voltage-gated Na+ (Nav) channels support action potentials in cortical pyramidal cells, Seleem (2016) reported that the melittin component of BV could inhibit the activity of Na/K-ATPase. The unequal expression of SCN1A genes that can occur on excitatory pyramidal neurons and inhibitory interneurons may be essential in epileptogenesis (Wei et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Bee venom acupuncture therapy ameliorates neuroinflammatory alterations in a pilocarpine-induced epilepticus model

2021

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Background: Bee venom (BV) is applied in different traditional medicinal therapies and is used worldwide to prevent and treat many acute and chronic diseases. Epilepsy has various neurological effects, e.g., epileptogenic insults; thus, it is considered a life-threatening condition. Seizures and their effects add to the burden of epilepsy because they can have health effects including residual disability and even premature mortality. The use of antiin ammatory drugs to treat epilepsy is controversial; therefore, the alternative nonchemical apitherapy bene ts of BV were evaluated in the present study by assessing neuroin ammatory changes in a pilocarpine-induced epilepticus model. Methods: Levels of electrolytes, neurotransmitters, and mRNA expression for some gate channels were determined. Moreover, ELISA assays were conducted to detect pro-and anti-in ammatory cytokines, whereas RT-PCR was performed to assess mRNA expression of Foxp3 and CTLA-4.Results: BV ameliorated the interruption in electrolytes and ions through voltage-and ligand-gated ion channels, and it limited neuronal excitability via rapid repolarization of action potentials. In addition, BV inhibited the high expression of proin ammatory cytokines.Conclusions: Acupuncture with BV was effective in preventing some of the deleterious consequences of epileptogenesis associated with high levels of glutamate and DOPA in the hippocampus. BV ameliorates changes in the expression of voltage-gated channels, rebalances blood electrolytes and neurotransmitters, and modulates the levels of pro-and antiin ammatory cytokines. Thus, BV could reduce the progression of epileptogenesis as a cotherapy with other antiepileptic drugs.

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