The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

Sun, Yingxin; Zhang, Juan; Yan, Yongjian; Ming-feng, Chi; Chen, Wenwen; Sun, Peng; Qin, Song

doi:10.1016/j.etap.2011.04.008

Cited by 25 publications

(28 citation statements)

References 27 publications

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“…M. chamomilla reduced the oxidative stress possibly by scavenging of free radicals produced by PQ with subsequent restoration in enzymatic activities and oxidative stress indicators, LPO and TAP, concentration in lung homogenates. From previous studies similar results were reported while studying the protective effects of C-phycocyanin[29] and quercetin[5] against PQ-induced lung injury in rat most probably via its antioxidant activity.…”

Section: Discussionsupporting

confidence: 78%

Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats

et al. 2014

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Background:Herbal medicines have been long used for antioxidant properties. The purpose of this study was to investigate the effect of hydroalcholic extract Matricaria chamomilla. L (M. chamomilla) against Paraquat (PQ) induced pulmonary injury in association with its antioxidant activity.Materials and Methods:Effective doses of PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. At the end of the experiment, lung tissue of the animals was separated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), lipid peroxidation (LPO) and total antioxidant power (TAP) were measured.Results:In these samples, the LPO, SOD, and GPx were higher in the PQ group as compared with controls. M. chamomilla extract ameliorated LPO, SOD, GPx and increased TAP in plasma and lung tissue of PQ induced changes. Co administration of PQ with M. chamomilla improved LPO and SOD, and GPx.Conclusion:M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative lung injury in PQ poisoning.

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Section: Discussionsupporting

confidence: 78%

Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats

et al. 2014

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“…Previous studies have shown that PC treatment reduced the expression of NF-κB in lung tissues 15 . However, it is unclear whether PC acts via a TLR-dependent mechanism to protect against PF.…”

Section: Resultsmentioning

confidence: 95%

“…14 found that PC may be the most active component of Spirulina extract for improving immunity, and PC can accelerate immune cell proliferation and differentiation by regulating the TLR2/TLR4 signaling pathway. Our previous research revealed that PC extracted from blue green algae could protect rats from paraquat-induced acute lung injury by preventing oxidative damage and inhibiting NF-κB mediated cytotoxicity 15 . PC also protected rats from lipopolysaccharide (LPS)-induced lung injury 16 .…”

Section: Introductionmentioning

confidence: 99%

Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway

et al. 2017

Sci Rep

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Our aim was to investigate the effects of phycocyanin (PC) on bleomycin (BLM)-induced pulmonary fibrosis (PF). In this study, C57 BL/6 wild-type (WT) mice and toll-like receptor (TLR) 2 deficient mice were treated with PC for 28 days following BLM exposure. Serum and lung tissues were collected on days 3, 7 and 28. Data shows PC significantly decreased the levels of hydroxyproline (HYP), vimentin, surfactant-associated protein C (SP-C), fibroblast specific protein-1 (S100A4) and α-smooth muscle actin (α-SMA) but dramatically increased E-cadherin and podoplanin (PDPN) expression on day 28. Moreover, PC greatly decreased the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO) at the earlier time. Reduced expression of key genes in the TLR2 pathway was also detected. Compared with WT mice, TLR2-deficient mice exhibited less injury, and the protective effect of PC was partly diminished in this background. These data indicate the anti-fibrotic effects of PC may be mediated by reducing W/D ratio, MPO, IL-6, TNF-α, protecting type I alveolar epithelial cells, inhibiting fibroblast proliferation, attenuating epithelial-mesenchymal transitions (EMT) and reducing oxidative stress. The TLR2-MyD88-NF-κB pathway plays an important role in PC-mediated reduction in pulmonary fibrosis.

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“…In this regard, PC has shown to attenuate lung damage; it reduces NF-κB, TNF-α, IκB and secondary oxidation MDA formation, and increases the activity of SOD and GPx compared to the non-exposed group (Sun et al, 2011) (Fig. 6C, Table 4).…”

Section: Lungmentioning

confidence: 88%

Nutraceutical properties of phycocyanin

Fernández-Rojas

Hernández‐Juárez²,

Pedraza‐Chaverrí

2014

Journal of Functional Foods

215

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The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

Cited by 25 publications

References 27 publications

Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats

Ameliorative effect of Matricaria chamomilla.L on paraquat: Induced oxidative damage in lung rats

Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway

Nutraceutical properties of phycocyanin

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