“…A relationship between helminth infections and protection against hyperinflammatory disorders has also been established in various mouse models for food allergy (Nagler-Anderson 2006), asthma (Smits, Hammad et al 2007;Amu, Saunders et al 2010), T1D (Zaccone, Fehervari et al 2003;Liu, Sundar et al 2009), CIA (Osada, Shimizu et al 2009) and EAE (La Flamme, Ruddenklau et al 2003;Wilson, Taylor et al 2010). Furthermore, different cross-sectional studies show that children living in farming environments are protected from childhood asthma and atopy and this correlation has been attributed to contact with livestock (Ege, Frei et al 2007) and hay and the consumption of raw cow's milk (Douwes, Cheng et al 2008;Loss, Apprich et al 2011). In farming environments, both outdoor and indoor microbial exposure are higher and more diverse compared to nonfarming environments (von Mutius, Braun-Fahrlander et al 2000;Ege, Mayer et al 2011).…”