2022
DOI: 10.22271/flora.2022.v10.i5a.829
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The protective effect of glycyrrhizin against chemotherapy-related toxicity in kidneys of rats: An experimental approach

Abstract: Chemotherapy is the most important treatment of neoplastic diseases and many antineoplastic agents have been developed for cancer treatment. A commonly used anticancer agent in chemotherapy is cyclophosphamide (CP). Despite the protective effect of CP against tumors, its use is limited due to nephrotoxicity, hepatotoxicity, urotoxicity, neurotoxicity, cardiotoxicity, teratogenicity, and immunotoxicity. Glycyrrhizin (GLZ) being a triterpenoid saponin, exhibits anti-oxidant, antiinflammatory, nephroprotective, h… Show more

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