The protective effect of hyperbaric oxygenation on the small intestine in ischemia-reperfusion injury

Yamada, Takaharu; Taguchi, Tomoaki; Hirata, Yasuhiko; Suita, Sachiyo; Yagi, Hiroshi

doi:10.1016/0022-3468(95)90748-3

Cited by 40 publications

(26 citation statements)

References 17 publications

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“…HBO treatment given prior to and during ischemic insult increased the survival of myocardium and ATP preservation (Yogaratnam et al 2006). This was a significant finding which suggested that undamaged integrity of cellular structure and tissue was a prerequisite to gain the greatest benefit from HBO (Yamada et al 1995;Chen et al 1998). We suggest that improvement in QT dispersion may be associated with various myocardial protection effects induced by HBO therapy.…”

Section: Discussionmentioning

confidence: 81%

Hyperbaric Oxygen Therapy Decreases QT Dispersion in Diabetic Patients

Kardeşoğlu

Aparcı

Uzun

et al. 2008

Tohoku J. Exp. Med.

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Diabetes mellitus is frequently associated with the malignant ventricular arrhythmias and sudden death. The QT dispersion is the difference between the longest and shortest QT interval calculated from the standard 12-lead electrocardiogram. The QT dispersion is suggested as an index of myocardial electrical activity. An increase in QT dispersion is associated with the malignant ventricular arrhythmias and sudden cardiac death. Diabetic patients receive hyperbaric oxygen (HBO) therapy for non-healing lower extremity ulcers. The aim of this study was to determine the effect of HBO therapy on QT dispersion in diabetic patients. Thirty diabetic patients (18 male and 12 female, 59.9 ± 10 years), who were planning to undergo ten sessions of HBO therapy in two weeks for non-healing lower extremity ulcers, were consecutively enrolled into the study. The 12-lead resting electrocardiography recordings were taken before the first HBO therapy and after the 10th HBOtherapy session. QT intervals were measured on electrocardiogram. QT intervals were corrected for heart rate by using Bazett's formula (corrected QT [QTc] = QT/√R -R [seconds]). QTc dispersion was significantly decreased from 59.8 ± 17.4 msec to 52.2 ± 15.5 msec after ten sessions of HBO therapy ( p < 0.05). However, maximum QTc, minimum QTc and mean QTc did not change significantly after HBO therapy. We have concluded that HBO therapy may reduce the risk of malignant ventricular arrhythmia and sudden cardiac death in diabetic patients when applied repetitively. hyperbaric oxygenation; diabetes mellitus; QT interval; electrocardiography.Tohoku

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Section: Discussionmentioning

confidence: 81%

Hyperbaric Oxygen Therapy Decreases QT Dispersion in Diabetic Patients

Kardeşoğlu

Aparcı

Uzun

et al. 2008

Tohoku J. Exp. Med.

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“…The administration of oxygen saturated solution to the intestine may partially restore mitochondrial function. Yamada et al [29] reported that secretion of TNF-α was inhibited after HBO treatment. In another study, the level of TNF-α increased significantly after recovery from trauma/hemorrhagic shock in rats, whereas HBO significantly reduced TNF-α secretion and inhibited excessive infl ammatory response.…”

Section: Discussionmentioning

confidence: 99%

Effects of hyperbaric oxygen on intestinal mucosa apoptosis caused by ischemia-reperfusion injury in rats

Zhou¹,

Sun²,

Wang³

2012

World Journal of Emergency Medicine

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“…Despite numerous reports about the positive effects of HBO in several clinical and experimental situations, their exact mechanism of action are not well known 11,12 , although part of them are currently being attributed to a reduction of the oxidative stress and inhibition of cytokine release 13 . HBO stimulates aerobic metabolism to preserve energy-rich compounds 11,13 and thus can reduce nitric oxide synthase (NOS) activity, increase the superoxide dismutase (SOD) activity, and decrease the levels of malondialdehyde 14 .…”

Section: Discussionmentioning

confidence: 99%

“…HBO stimulates aerobic metabolism to preserve energy-rich compounds 11,13 and thus can reduce nitric oxide synthase (NOS) activity, increase the superoxide dismutase (SOD) activity, and decrease the levels of malondialdehyde 14 . These activities were related to the pathological cascade of free radical reactions and further yields more reactive oxidative specimens (ROS) that were responsible to impair the cellular structure and function.…”

Section: Discussionmentioning

confidence: 99%

Effect of different periods of hyperbaric oxygen on ischemia-reperfusion injury of rat small bowel

et al. 2008

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PURPOSE: To determine whether hyperbaric oxygen (HBO) could effectively protect the small intestine mucosa against an ischemic insult, according to different periods of application. METHODS: The gut of 32 male rats was subjected to 60-min ischemia (clamping the mesenteric artery and vein); After they were further reperfused upon clamp opening during 60 min. Animal groups were as follows. GII = placed on HBO during the ischemia period; GIII = placed on HBO during reperfusion; GIV = treated with HBO throughout the ischemia-reperfusion period. Some animals (GI) did not receive HBO treatment at all and served as reference of ischemia-reperfusion injury (IR). HBO was carried out in a cylindrical acrylic chamber (2.0 ATA). Samples of small bowel were prepared for H.E staining for histological evaluations. RESULTS: The histological injury of mucosa was significantly less when HBO was administered during the ischemia period (17.6 ± 0.6) as compared with the IR (21.3 ± 1.8). HBO was not effective when applied during reperfusion (23.1 ± 2.1) or during the ischemia plus reperfusion period (18.7 ± 1.9). The thickness of the mucosa was preserved by HBO in ischemia (327.50 ± 30.23 µm) in comparison with the IR (172.79 ± 5.95 µm). In the periods of reperfusion (162.50 ± 6.05 µm) and ischemia plus reperfusion (296.49 ± 20.01 µm) the mucosa revealed a structural injury. CONCLUSION: Hyperbaric oxygen affects the ischemic insult of small bowel, being the favorable effect obtained when hyperbaric oxygen was administered early in the ischemic period.

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The protective effect of hyperbaric oxygenation on the small intestine in ischemia-reperfusion injury

Cited by 40 publications

References 17 publications

Hyperbaric Oxygen Therapy Decreases QT Dispersion in Diabetic Patients

Hyperbaric Oxygen Therapy Decreases QT Dispersion in Diabetic Patients

Effects of hyperbaric oxygen on intestinal mucosa apoptosis caused by ischemia-reperfusion injury in rats

Effect of different periods of hyperbaric oxygen on ischemia-reperfusion injury of rat small bowel

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