The protective effect of isoflurane pretreatment on liver IRI by suppressing noncanonical pyroptosis of liver macrophages

Lu, Jiao; Wang, Xiaoying; Feng, Zhihao; Chen, Yu‐Cheng; Wen, Diguang; Liu, Zuojin

doi:10.1016/j.intimp.2021.107977

Cited by 10 publications

(5 citation statements)

References 36 publications

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“…Iisoflurane pretreatment also inhibited caspase-11 expression and noncanonical pyroptosis-related production of cytokines (IL-1beta and IL-18). These findings suggest that isoflurane could be a pharmacological agent for liver IRI prevention and thus deserves more attention and further investigation (71).…”

Section: The Nlrp3 Activation Of Liver Macrophages In Lirimentioning

confidence: 88%

The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury

Zhang

Shao

et al. 2022

Front. Immunol.

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Ischemia-reperfusion injury (IRI) is considered an inherent component involved in liver transplantation, which induce early organ dysfunction and failure. And the accumulating evidences indicate that the activation of host innate immune system, especially hepatic macrophages, play a pivotal role in the progression of LIRI. Inflammasomes is a kind of intracellular multimolecular complexes that actively participate in the innate immune responses and proinflammatory signaling pathways. Among them, NLRP3 inflammasome is the best characterized and correspond to regulate caspase-1 activation and the secretion of proinflammatory cytokines in response to various pathogen-derived as well as danger-associated signals. Additionally, NLRP3 is highly expressed in hepatic macrophages, and the assembly of NLRP3 inflammasome could lead to LIRI, which makes it a promising therapeutic target. However, detailed mechanisms about NLRP3 inflammasome involving in the hepatic macrophages-related LIRI is rarely summarized. Here, we review the potential role of the NLRP3 inflammasome pathway of hepatic macrophages in LIRI, with highlights on currently available therapeutic options.

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Section: The Nlrp3 Activation Of Liver Macrophages In Lirimentioning

confidence: 88%

The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury

Zhang

Shao

et al. 2022

Front. Immunol.

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“…Isoflurane, commonly used as an inhaled anesthesia, has been shown to reduce the LPS-induced NLRP3 activation in murine macrophages. Its usage as graft pre-treatment in a murine model of IRI reduces the effect of ischemia-reperfusion injury, thus becoming a potential therapy for the prevention of LIRI [93]. The use of pharmacological blockers targeting the NLRP3 inflammasome in liver ischemia during static cold storage or through extracorporeal organ support could be a suitable strategy to increase the success of liver transplantation.…”

Section: Type Of Cld Effect Sex and Species Referencesmentioning

confidence: 99%

NLRP3 Inflammasome in Acute and Chronic Liver Diseases

Sayaf,

Battistella,

Russo

2024

IJMS

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NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is an intracellular complex that upon external stimuli or contact with specific ligands, recruits other components, forming the NLRP3 inflammasome. The NLRP3 inflammasome mainly mediates pyroptosis, a highly inflammatory mode of regulated cell death, as well as IL-18 and IL-1β production. Acute and chronic liver diseases are characterized by a massive influx of pro-inflammatory stimuli enriched in reactive oxygen species (ROS) and damage-associated molecular patterns (DAMPs) that promote the assemblage and activation of the NLRP3 inflammasome. As the major cause of inflammatory cytokine storm, the NLRP3 inflammasome exacerbates liver diseases, even though it might exert protective effects in regards to hepatitis C and B virus infection (HCV and HBV). Here, we summarize the current knowledge concerning NLRP3 inflammasome function in both acute and chronic liver disease and in the post liver transplant setting, focusing on the molecular mechanisms involved in NLRP3 activity.

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“…Numerous studies on the role of macrophage pyroptosis in liver disease have been reported by researchers, which have been summarized in Table 1 . Notably, macrophage pyroptosis plays a crucial role in various liver diseases ( 58 ).…”

Section: The Role Of Macrophage Pyroptosis In Liver Diseasesmentioning

confidence: 99%

“…This implies the involvement of non-canonical pyroptosis in the macrophage-driven hepatic IRI. Isoflurane intervention curbs this pyroptosis by inhibiting intracellular Ca 2+ levels, NF-κB translocation, NLPR3 inflammasome activation, and the caspase-11-mediated non-canonical pyroptosis pathway ( 58 ). The downregulation of ApoA-1 during IRI after liver transplantation increases pyroptosis (but not apoptosis) in liver macrophages.…”

Section: The Role Of Macrophage Pyroptosis In Liver Diseasesmentioning

confidence: 99%

Unveiling the flames: macrophage pyroptosis and its crucial role in liver diseases

Ni,

Chen,

Zhao

et al. 2024

Front. Immunol.

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Macrophages play a critical role in innate immunity, with approximately 90% of the total macrophage population in the human body residing in the liver. This population encompasses both resident and infiltrating macrophages. Recent studies highlight the pivotal role of liver macrophages in various aspects such as liver inflammation, regeneration, and immune regulation. A novel pro-inflammatory programmed cell death, pyroptosis, initially identified in macrophages, has garnered substantial attention since its discovery. Studies investigating pyroptosis and inflammation progression have particularly centered around macrophages. In liver diseases, pyroptosis plays an important role in driving the inflammatory response, facilitating the fibrotic process, and promoting tumor progression. Notably, the role of macrophage pyroptosis cannot be understated. This review primarily focuses on the role of macrophage pyroptosis in liver diseases. Additionally, it underscores the therapeutic potential inherent in targeting macrophage pyroptosis.

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The protective effect of isoflurane pretreatment on liver IRI by suppressing noncanonical pyroptosis of liver macrophages

Cited by 10 publications

References 36 publications

The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury

The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury

NLRP3 Inflammasome in Acute and Chronic Liver Diseases

Unveiling the flames: macrophage pyroptosis and its crucial role in liver diseases

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