The protective effect of lycopene intake on bone loss in ovariectomized rats

Abstract

Antioxidant lycopene supplementation has been shown to decrease oxidative stress and have beneficial effects on bone health. However, it remains unclear whether lycopene exerts its beneficial effect on bone metabolism through mitigation of oxidative stress in vivo. The aim of this study was to investigate whether lycopene intake protects against bone loss by reducing oxidative stress in ovariectomized rats. Female Sprague-Dawley 6-week-old rats were ovariectomized and randomly divided into four groups according to the lycopene content of their diet: 0, 50, 100, and 200 ppm. The tibial bone mineral density (BMD) in the 50, 100, and 200 ppm groups was significantly higher than that in the 0 ppm group. Serum and urinary bone resorption marker levels were significantly lower in the 50, 100, and 200 ppm groups than in the 0 ppm group. There was no significant difference in systemic oxidative stress markers among all groups. However, systemic oxidative stress levels were inversely correlated with the tibial BMD. Our findings suggest that lycopene intake significantly inhibits bone loss by suppressing bone resorption in ovariectomized rats. Further studies are necessary to clarify the effect of lycopene on oxidative stress in local tissues such as bone tissue.

Effect of lycopene on titanium implant osseointegration in ovariectomized rats

“…A number of studies have demonstrated the beneficial effects of lycopene on bone metabolism [ 23 , 24 , 26 , 41 – 43 ]. In vitro studies have shown that lycopene promotes proliferation and differentiation of osteoblasts [ 26 , 44 ] and suppresses osteoclastogenesis and differentiation of osteoclasts in normal and OVX rats [ 26 , 45 ].…”

FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus

“…The femoral bone strength at the middle diaphysis was examined by measuring the mechanical strength as previously reported 29 . Briefly, the force necessary to produce a break at the center of the femur was measured according to the following conditions: the sample space was 1.0 cm, the plunger speed was 100.0 mm/min, the load range was 50.0 kg, and the chart speed was 120.0 cm/min.…”

Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies

“…Lycopene has been shown in multiple studies to dose-dependently increase BMD in ovariectomized rats [ 151 ]. Similarly, lycopene reduced bone fragility in ovariectomized rats and improved femoral bone energy, as assessed using a mechanical breaking test [ 14 ]. More recently, lycopene supplementation in ovariectomized rats was found to significantly alter levels of biomarkers of bone turnover in blood and urine, reducing bone resorption and increasing osteoblast activity.…”

“… Schematic representation of the potential effects of lycopene on bone cells (reference from [ 13 , 14 , 99 ]. …”

“…Diets rich in phytochemicals, particularly carotenoids from fruits and vegetables, have been found to be effective for the maintenance of bone mineral status [ 11 , 12 ]. Among them, the potential protective effects of lycopene against bone loss have been recently documented [ 13 , 14 ]. Lycopene is an acyclic carotenoid, containing 11 conjugated double bonds in the all- trans -isomeric form or various cis -configurations [ 15 ].…”