The Protective Effect of Peanut, Walnut, and Almond Consumption on the Development of Breast Cancer

Soriano-Hernández, Alejandro D.; Madrigal-Pérez, Daniela; Galvan-Salazar, Hector R; Arreola-Cruz, Alejandro; Briseño-Gomez, Lorena; Guzmán-Esquivel, José; Dobrovinskaya, Oxana; Lara-Esqueda, Agustín; Rodríguez‐Sánchez, Iram P.; Baltazar-Rodríguez, Luz M.; Espinoza-Gomez, Francisco; Martínez‐Fierro, Margarita L.; De-Leon-Zaragoza, Luis; Olmedo-Buenrostro, Bertha Alicia; Delgado‐Enciso, Iván

doi:10.1159/000369997

Cited by 23 publications

(13 citation statements)

References 13 publications

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“…However, consumption of charcuterie, fresh fish, groundnut and soybean was significantly associated with risk of BC. Our results disagree with a study in Mexico City published 2015, who asserted that large groundnut consumption significantly reduces the risk for BC by 2–3 times [ 45 ]. Regarding soybean consumption, our results are consistent with those in China from 2015, which have also shown the effect of soy-associated BC increased risk [ 46 ].…”

Section: Discussioncontrasting

confidence: 99%

Behavioral risk factors of breast cancer in Bangui of Central African Republic: A retrospective case-control study

et al. 2017

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Breast cancer is recognized as a major public health problem in developing countries; however, there is very little evidence of behavioral factors associated with breast cancer risk. This study was conducted to identify lifestyles as risk factors for breast cancer among Central African women. A case-control study was conducted with 174 cases confirmed histologically by the pathology unit of the National Laboratory and 348 age-matched controls. Data collection tools included a questionnaire with interviews and medical records of patients. Data were analyzed using SPSS software version 20. Odd ratio (OR) and 95% confidence intervals (95% CI) were obtained by unconditional logistic regression. In total, 522 women were studied with a mean age of 45.8 (SD = 13.4) years. By unconditional logistic regression model, women with breast cancer were more likely to have attained illiterate and elementary education level [11.23 (95% CI, 4.65–27.14) and 2.40 (95% CI, 1.15–4.99)], married [2.09 (95% CI, 1.18–3.71)], positive family history [2.31 (95% CI, 1.36–3.91)], radiation exposure [8.21 (95% CI, 5.04–13.38)], consumption charcuterie [10.82 (95% CI, 2.39–48.90)], fresh fish consumption [4.26 (95% CI, 1.56–11.65)], groundnut consumption [6.46 (95% CI, 2.57–16.27)], soybean consumption [16.74 (95% CI, 8.03–39.84)], alcohol [2.53 (95% CI, 1.39–4.60)], habit of keeping money in bras[3.57 (95% CI, 2.24–5.69)], overweight [5.36 (95% CI, 4.46–24.57)] and obesity [3.11(95% CI, 2.39–20.42)]. However, decreased risk of breast cancer was associated with being employed [0.32 (95% CI, 0.19–0.56)], urban residence [0.16 (95% CI, 0.07–0.37)], groundnut oil consumption [0.05 (95% CI, 0.02–0.14)], wine consumption [0.16 (95% CI, 0.09–0.26)], non habit of keeping cell phone in bras [0.56 (95% CI, 0.35–0.89)] and physical activity [0.71(95% CI, 0.14–0.84)]. The study showed that little or no education, marriage, positive family history of cancer, radiation exposure, charcuterie, fresh fish, groundnut, soybean, alcohol, habit of keeping money in bras, overweight and obesity were associated with breast cancer risk among Central African women living in Bangui. Women living in Bangui should be more cautious on the behavioral risk associated with breast cancer.

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Section: Discussioncontrasting

confidence: 99%

Behavioral risk factors of breast cancer in Bangui of Central African Republic: A retrospective case-control study

et al. 2017

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“…Toledo et al [111] indicated also that walnut-enriched diets could modulate breast cancer growth. These results are in accordance with those reported by Soriano-Hernandez et al [112] where, in the group that consumed higher amounts of walnuts, almonds and peanuts, the breast cancer risk was between 55 and 67% less likely.…”

Section: Association Between Nuts and Cancersupporting

confidence: 93%

Health Benefits of Nut Consumption in Middle-Aged and Elderly Population

et al. 2019

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Aging is considered the major risk factor for most chronic disorders. Oxidative stress and chronic inflammation are two major contributors for cellular senescence, downregulation of stress response pathways with a decrease of protective cellular activity and accumulation of cellular damage, leading in time to age-related diseases. This review investigated the most recent clinical trials and cohort studies published in the last ten years, which presented the influence of tree nut and peanut antioxidant diets in preventing or delaying age-related diseases in middle-aged and elderly subjects (≥55 years old). Tree nut and peanut ingestion has the possibility to influence blood lipid count, biochemical and anthropometric parameters, endothelial function and inflammatory biomarkers, thereby positively affecting cardiometabolic morbidity and mortality, cancers, and cognitive disorders, mainly through the nuts’ healthy lipid profile and antioxidant and anti-inflammatory mechanisms of actions. Clinical evidence and scientific findings demonstrate the importance of diets characterized by a high intake of nuts and emphasize their potential in preventing age-related diseases, validating the addition of tree nuts and peanuts in the diet of older adults. Therefore, increased consumption of bioactive antioxidant compounds from nuts clearly impacts many risk factors related to aging and can extend health span and lifespan.

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“…Walnuts may be a particularly attractive whole food approach for cancer prevention. They are readily available, widely consumed, and contain an excellent profile of bioactive components that may exert complex and synergistic effects on tumorigenesis (16,22,(24)(25)(26)(27)(28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Effects of Walnut Consumption on Colon Carcinogenesis and Microbial Community Structure

Nakanishi

Chen

Qendro

et al. 2016

Cancer Prevention Research

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Walnuts are composed of a complex array of biologically active constituents with individual cancer-protective properties. Here, we assessed the potential benefit of whole walnut consumption in a mouse tumor bioassay using azoxymethane. In study 1, a modest reduction (1.3-fold) in tumor numbers was observed in mice fed a standard diet (AIN-76A) containing 9.4% walnuts (15% of total fat). In study 2, the effects of walnut supplementation was tested in the Total Western Diet (TWD). There was a significant reduction (2.3-fold; P < 0.02) in tumor numbers in male mice fed TWD containing 7% walnuts (10.5% of total fat). Higher concentrations of walnuts lacked inhibitory effects, particularly in female mice, indicating there may be optimal levels of dietary walnut intake for cancer prevention. Since components of the Mediterranean diet have been shown to affect the gut microbiome, the effects of walnuts were therefore tested in fecal samples using 16S rRNA gene sequencing. Carcinogen treatment reduced the diversity and richness of the gut microbiome, especially in male mice, which exhibited lower variability and greater sensitivity to environmental changes. Analysis of individual operational taxonomic units (OTU) identified specific groups of bacteria associated with carcinogen exposure, walnut consumption, and/or both variables. Correlation analysis also identified specific OTU clades that were strongly associated with the presence and number of tumors. Taken together, our results indicate that walnuts afford partial protection to the colon against a potent carcinogenic insult, and this may be due, in part, to walnut-induced changes to the gut microbiome. Cancer Prev Res; 9(8); 692–703. ©2016 AACR.

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The Protective Effect of Peanut, Walnut, and Almond Consumption on the Development of Breast Cancer

Cited by 23 publications

References 13 publications

Behavioral risk factors of breast cancer in Bangui of Central African Republic: A retrospective case-control study

Behavioral risk factors of breast cancer in Bangui of Central African Republic: A retrospective case-control study

Health Benefits of Nut Consumption in Middle-Aged and Elderly Population

Effects of Walnut Consumption on Colon Carcinogenesis and Microbial Community Structure

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