The Protective Effect of Platelet Rich Plasma Against Cisplatin-Induced Ototoxicity

Yurtsever, Kum Nurcan; Baklacı, Deniz; Güler, İsmail; Kuzucu, İhsan; Kum, Rauf Oğuzhan; Özhamam, Esra; Özcan, Müge; Dere, Hüseyin

doi:10.1097/scs.0000000000006645

Cited by 4 publications

(11 citation statements)

References 14 publications

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“…PRP has a positive effect on healing due to its high growth factor concentration.27 In addition, previous animal studies have shown that these positive effects of PRP application also increase nerve damage regeneration.27 In a study by Yurtsever et al, ITM PRP application was reported to be effective in cisplatin-induced ototoxicity and to reduce hearing loss and cochlear cell damage. 21 Similarly, in the present study, we found that a single dose of ITM PRP application after AT reduced the severity of hearing loss and cochlear cell damage. However, these positive effects of PRP were limited compared to melatonin and steroid treatment.…”

Section: Discussion Discussionsupporting

confidence: 85%

“…[16][17][18] The use of melatonin, an important FOR scavenger, can also prevent and/or correct noise-related cochlear damage and related hearing loss.8-19 Glucocorticoid has been reported to be another pharmacological agent with protective and therapeutic effects after noise exposure.8-20 Platelet-rich plasma (PRP) is also used for the same purpose. 21 In this study, we aimed to investigate the potential therapeutic and/or protective effects of melatonin, PRP, and steroid treatment on NIHL in rats through histopathological and electrophysiological evaluations.…”

Section: Introduction Introductionmentioning

confidence: 99%

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The potential therapeutic and/or protective effects of steroid, PRP and melatonin on noise-induced hearing loss in rats

Baklacı¹,

Kum²,

Çolak³

et al. 2023

ACH Medical Journal

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Introduction: Introduction: To investigate the potential therapeutic and protective effects of steroid, platelet-rich plasma (PRP), and melatonin treatment on noise-induced hearing loss (NIHL).Methods: Methods: A total of 42 rats were divided into five groups: Group 1 did not receive any drug, Group 2 received methylprednisolone via the intratympanic route at 24 hours after acoustic trauma (AT), Group 3 received PRP via the intratympanic route at 24 hours after AT, Group 4 received intraperitoneal melatonin at 24 hours before AT, and Group 5 received intraperitoneal melatonin at 24 hours after AT. Two of the 42 rats were sacrificed and used for blood source material to prepare PRP. Each group was exposed to noise at the 105 dB sound pressure level for 12 hours to induce AT. Auditory brainstem responses (ABRs) were determined before AT and on days 1 and 28 after AT, and then histomorphological assessment was performed to identify cellular changes.Results: Results: In the ABR test performed on day 28 after AT, a statistically significant improvement was found in the hearing thresholds of all the four treatment groups compared to the control group (p < 0.05). The improvement in the melatonin groups (Groups 4 and 5) was statistically significantly better than in the steroid and PRP groups (p < 0.05). Although the hearing thresholds of the steroid group were better than those of the PRP group, this difference was not statistically significant (p > 0.05). As a result of the histopathological examination performed on day 28 after AT, cell loss after AT was statistically significantly reduced in all the experimental groups compared to the control group (p < 0.05). Conclusion: Conclusion: Based on ABR testing and histopathological fin-dings in a rat model, we conclude that melatonin may be effective in reducing NIHL and noise-induced cochlear damage.

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Section: Discussion Discussionsupporting

confidence: 85%

Section: Introduction Introductionmentioning

confidence: 99%

The potential therapeutic and/or protective effects of steroid, PRP and melatonin on noise-induced hearing loss in rats

Baklacı¹,

Kum²,

Çolak³

et al. 2023

ACH Medical Journal

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“…Ototoxicity refers to the occurrence of the symptoms of hearing loss and/or balance disorder via functional impairment or cellular degeneration in the inner ear caused by exposure to different therapeutic agents and chemicals. There should be the development of sensorineural hearing loss of 20 dB or more in at least two subsequent frequencies so that it is possible to talk about ototoxicity in the audiological evaluation ( 1 , 2 , 3 ). Numerous drugs and chemicals such as antibiotics of the aminoglycoside group, many antineoplastic agents including cisplatin, some diuretics, anti-inflammatory and antimalarial drugs and some antiseptic solutions, arsenic, and ethyl and methyl alcohol are known to have ototoxic effects ( 1 , 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…Cisplatin (cis-diamminedichloroplatinum-II) is a chemotherapeutic agent which is effectively, successfully, and commonly used to treat various malignant diseases such as testicular cancers, head and neck cancers, small cell lung cancer, ovarian cancers, central nervous system malignancies, gastric cancers, and bladder cancers ( 2 , 3 ). Cisplatin frequently causes ototoxicity and nephrotoxicity and may have significant adverse effects such as bone marrow suppression, gastrointestinal toxicity, and peripheral neuropathy that limit its use in clinical practice ( 1 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Protective and Therapeutic Effect of Platelet-Rich Plasma on Experimental Cisplatin Ototoxicity

Gözaydın,

Ünal,

Özdemir

et al. 2023

TAO

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Objective: Cisplatin is a chemotherapeutic agent with an ototoxic effect that is frequently used in head and neck cancers. There are studies in the literature conducted with various antioxidant substances to protect and/or prevent ototoxicity. This study aims to investigate whether platelet-rich plasma (PRP) has a protective and therapeutic effect on cisplatin ototoxicity. Methods: A total of 40 Sprague Dawley albino rats were divided into six groups as control group (n=6), PRP-only group (n=6), cisplatin group (n=6), cisplatin + PRP group (n=6), PRP + cisplatin group (n=6), and donor group (n=10). At the beginning of the study and the 8 th day, they were tested with distortion product otoacoustic emission (DPOAE). Assessment of DPOAE results was based on the signal-to-noise ratio in 2000, 3000, 4000, 6000, and 8000 Hz frequency bands. On the 8 th day, the rats were sacrificed. For histological examinations, the temporal bones were dissected and fixed. After hematoxylin and eosin staining, the tissues were evaluated by light microscopy. Results: In the DPOAE tests performed on the 0 th and 8 th days of the cisplatin group, it was observed that cisplatin caused hearing loss in the rat ears. It was determined that the cisplatin group at 2000 Hz, 3000 Hz and 4000 Hz had a significant decrease in hearing compared to all groups (p<0.015), while the cisplatin group at 6000 and 8000 Hz was characterized by hearing loss at a higher rate than all groups (p<0.001). At the end of the study, negative effects of cisplatin on both cellular dimensions (cytoplasmic vacuolization, cell degeneration, dilatation, apoptotic cells, nerve degeneration) and hearing function were observed. No protective or therapeutic effect of PRP on cisplatin ototoxicity was observed. Conclusion: Our study showed that platelet-rich plasma did not have a significant effect in the treatment of hearing loss due to cisplatin ototoxicity and in preventing hearing loss in rats.

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“…Different from fluid-like platelet-rich plasma, platelet gel is a gel-like material rich in platelets, as its name suggests ( Figure 1 ), rapidly formed when platelet-rich plasma is mixed with thrombin and calcium chloride ( Figure 2 ). Platelet-rich plasma containing a high concentration of platelets is obtained by centrifugating the autologous whole blood of the patient [ 44 , 45 , 46 , 47 ]. Mixing platelet-rich plasma with thrombin and calcium chloride not only leads to the gelatinization of plasma, but also leads to the activation of platelets that releases numerous growth factors from platelets into the environment of the tissue [ 41 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment Effect of Platelet Gel on Reconstructing Bone Defects and Nonunions: A Review of In Vivo Human Studies

Lin

2022

IJMS

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In ideal circumstances, a fractured bone can heal properly by itself or with the aid of clinical interventions. However, around 5% to 10% of bone fractures fail to heal properly within the expected time even with the aid of clinical interventions, resulting in nonunions. Platelet gel is a blood-derived biomaterial used in regenerative medicine aiming to promote wound healing and regeneration of damaged tissues. The purpose of this paper is to review relevant articles in an attempt to explore the current consensus on the treatment effect of platelet gel on reconstructing bone defects and nonunions, hoping to provide a valuable reference for clinicians to make treatment decisions in clinical practice. Based on the present review, most of the studies applied the combination of platelet gel and bone graft to reconstruct bone defects and nonunions, and most of the results were positive, suggesting that this treatment strategy could promote successful reconstruction of bone defects and nonunions. Only two studies tried to apply platelet gel alone to reconstruct bone defects and nonunions, therefore a convincing conclusion could not be made yet regarding the treatment effect of platelet gel alone on reconstructing bone defects and nonunions. Only one study applied platelet gel combined with extracorporeal shock wave therapy to reconstruct nonunions, and the results were positive; the hypothetical mechanism of this treatment strategy is reasonable and sound, and more future clinical studies are encouraged to further justify the effectiveness of this promising treatment strategy. In conclusion, the application of platelet gel could be a promising and useful treatment method for reconstructing bone defects and nonunions, and more future clinical studies are encouraged to further investigate the effectiveness of this promising treatment method.

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The Protective Effect of Platelet Rich Plasma Against Cisplatin-Induced Ototoxicity

Cited by 4 publications

References 14 publications

The potential therapeutic and/or protective effects of steroid, PRP and melatonin on noise-induced hearing loss in rats

The potential therapeutic and/or protective effects of steroid, PRP and melatonin on noise-induced hearing loss in rats

Protective and Therapeutic Effect of Platelet-Rich Plasma on Experimental Cisplatin Ototoxicity

Treatment Effect of Platelet Gel on Reconstructing Bone Defects and Nonunions: A Review of In Vivo Human Studies

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