The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-κB and ROS/AMPK pathway

Luo, Xing; Bao, Xiaoyi; Weng, Xiuzhu; Bai, Xiaoxuan; Feng, Yi; Huang, Jianxin; Liu, Shaoyu; Jia, Haibo; Yu, Bo

doi:10.1016/j.lfs.2021.120064

Cited by 69 publications

(43 citation statements)

References 39 publications

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“…Previous studies have reported that quercetin has a protective effect on atherosclerosis, including inhibition of dendritic cell activation and excessive ROS production [ 23 , 24 ]. Moreover, our in vitro study supported that quercetin improved oxidative stress in pyroptotic macrophages induced by LPS/ATP [ 25 ]. In this study, we will further elucidate the potential mechanisms by which quercetin ameliorates oxidative stress.…”

Section: Introductionmentioning

confidence: 67%

A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

et al. 2022

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Section: Introductionmentioning

confidence: 67%

A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

et al. 2022

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“…Interestingly, QUR can directly reduce the level of serum IL-6, TNF-α and other inflammatory factors in PCOS [ 17 , 82 ], reducing inflammation for ovulation disorders, insulin resistance and other adverse effects. Studies have shown that QUR can inhibit the inflammatory response caused by the activation of NLRP3 inflammasome in macrophages [ 83 , 84 , 85 ]. Other studies confirmed that QUR can regulate the SIRT1/NF-κB signaling pathway to inhibit the transformation and polarization of monocytes into macrophages [ 86 ] and improve the inflammatory injury induced by lipopolysaccharide (LPS) [ 87 , 88 ] so as to reduce the secretion of inflammatory factors.…”

Section: Effect and Mechanism Of Quercetin In Polycystic Ovary Syndromementioning

confidence: 99%

Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review

Chen

Fan

et al. 2022

Molecules

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Polycystic ovary syndrome (PCOS) is a common multisystem disease with reproductive, metabolic and psychological abnormalities. It is characterized by a high prevalence rate in women of childbearing age and highly heterogeneous clinical manifestations, which seriously harm women’s physical and mental health. Quercetin (QUR) is a natural compound of flavonoids found in a variety of foods and medicinal plants. It can intervene with the pathologic process of PCOS from multiple targets and channels and has few adverse reactions. It is mentioned in this review that QUR can improve ovulation disorder, relieve Insulin resistance (IR), reduce androgen, regulate lipid metabolism, regulate gut microbiota and improve vascular endothelial function, which is of great significance in the treatment of PCOS.

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“…Only Liu et al reported that apple polyphenols extract (APE) ameliorated DSS-induced acute ulcerative colitis through inhibiting intestinal epithelial cell apoptosis and pyroptosis pathway [48]. Luo et al reported that Que possessed a protective effect on macrophages pyroptosis via TLR2/Myd88/NF-κB pathway [49]. Until now, there was no other report about the effect of PCA on pyroptosis signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Protocatechuic acid and quercetin attenuate ETEC-caused IPEC-1 cell inflammation and injury associated with inhibition of necroptosis and pyroptosis signaling pathways

Xiao

et al. 2022

Preprint

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Background Necroptosis and pyroptosis are newly identified forms of programmed cell death, which play a vital role in development of many gastrointestinal disorders. Although plant polyphenols have been reported to protect intestinal health, it is still unclear whether there is a beneficial role of plant polyphenols in modulating necroptosis and pyroptosis in intestinal porcine epithelial cell line (IPEC-1) infected with enterotoxigenic Escherichia coli (ETEC) K88. This research was conducted to explore whether plant polyphenols including protocatechuic acid (PCA) and quercetin (Que), attenuated inflammation and injury of IPEC-1 caused by ETEC K88 through regulating necroptosis and pyroptosis signaling pathways. Methods IPEC-1 cells were treated with PCA (40 µM) or Que (10 µM) in the presence or absence of ETEC K88. Results PCA and Que decreased ETEC K88 adhesion and endotoxin level in cell supernatant. PCA and Que increased cell number and decreased lactate dehydrogenases (LDH) activity in cell supernatant. PCA and Que improved transepithelial electrical resistance (TEER) and reduced fluorescein isothiocyanate-labeled dextran (FD4) flux, and enhanced membrane protein abundance of occludin, claudin-1 and ZO-1, and rescued distribution of these tight junction proteins. PCA and Que also declined cell necrosis ratio. PCA and Que reduced mRNA abundance and concentration of tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-8, and down-regulated gene expression of toll-like receptors 4 (TLR4) and its downstream signals. PCA and Que down-regulated protein abundance of total receptor interacting protein kinase 1 (t-RIP1), phosphorylated-RIP1 (p-RIP1), p-RIP1/t-RIP1, t-RIP3, p-RIP3, mixed lineage kinase-like protein (MLKL), p-MLKL, motility related protein 1 (DRP1), phosphoglycerate mutase 5 (PGAM5) and high mobility protein 1 (HMGB1). Moreover, PCA and Que reduced protein abundance of nod-like receptor protein 3 (NLRP3), nod-like receptors family CARD domain-containing protein 4 (NLRC4), apoptosis-related macular protein (ASC), gasdermin D (GSDMD) and caspase-1. Conclusions In general, our data suggest that PCA and Que are capable of attenuating ETEC-caused intestinal inflammation and damage, which is maybe associated with inhibition of necroptosis and pyroptosis signaling pathways.

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The protective effect of quercetin on macrophage pyroptosis via TLR2/Myd88/NF-κB and ROS/AMPK pathway

Cited by 69 publications

References 39 publications

A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

Potential Role of Quercetin in Polycystic Ovary Syndrome and Its Complications: A Review

Protocatechuic acid and quercetin attenuate ETEC-caused IPEC-1 cell inflammation and injury associated with inhibition of necroptosis and pyroptosis signaling pathways

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