The protective effect of simvastatin against ultraviolet B-induced corneal endothelial cell death

Ho, Yi-Ru; Lin, Chih‐Hung; Kuo, Chan‐Yen

doi:10.4103/ijo.ijo_93_18

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…In the present study, the cells with UV-B exposure decreased VEGF-A concentration by 84%. Nevertheless, some studies showed that VEGF-A expression in the UV-B irradiated cornea was dramatically increased (7,12,26). An explanation for this contradictory results may be that UV-B radiation at a relatively high level (10 J cm À2 ) may seriously impair normal physiological function of cells and eventually lead to cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, small molecular antioxidants and anti-inflammatory agents (e.g. ascorbic acid, citicoline, fucoxanthin, EGCG, rebamipide, carteolol, cis-UCA, curcumin, simvastatin, nicotinamide, nicotinamide mononucleotide and nicotinamide adenine dinucleotide) have been explored for UVB-induced cornea injuries (5)(6)(7)(8)(9)(10)(11)(12)(13). Among these compounds, cis-UCA (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Efficient Synthesis and Evaluation of Novel Sulfonated Dihydropyrimidinthione Derivatives for the Treatment of UV‐B‐Induced Corneal Damage

Jiang

Qin

et al. 2022

Photochem & Photobiology

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UV-B-induced corneal damage remains a challenge in clinics, and it is needed to develop novel and effective medicines against UV-B induced photodamage. 3,4-Dihydropyrimidine-2 (1H)-thione derivatives have shown many interesting biological activities, including antibacterial, anti-inflammatory, antioxidant, etc. In order to find a promising anticorneal photodamage agent, we designed and synthesized two novel sulfonated dihydropyrimidinthione derivatives to evaluate cytoprotective effect against UV-B-mediated photodamage. With simple structure, compound 6 possessed good water solubility, photostability and biocompatibility. We demonstrated that 6 exhibited significant cytoprotective effects against UV-B-mediated photodamage and the cell viability was up to 93% at 0.2 mg mL À1 . The corneal cells were highly sensitive to UV-B radiation, resulting in the release of inflammatory mediators and DNA damage, which were significantly reversed by 6. Moreover, compound 6 reduced Bax and cleaved Caspase-3 expressions to suppress UV-B mediated the intrinsic apoptosis pathway. Our findings suggest that 6 is a promising UV-B resistant agent with potential to be a promising drug candidate for the treatment of corneal photodamage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficient Synthesis and Evaluation of Novel Sulfonated Dihydropyrimidinthione Derivatives for the Treatment of UV‐B‐Induced Corneal Damage

Jiang

Qin

et al. 2022

Photochem & Photobiology

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Is there a relationship between statin use and corneal specular microscopy and topography findings?

Kurtul¹

2021

Beyoglu Eye J

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Objectives: Information about the possible effect of statins on the human corneal endothelium is still not clear. This study was the first known investigation of the influence of statins on corneal specular microscopy (SM) and topography parameters. Methods: Thirty-four patients using a statin (atorvastatin) as hyperlipidemia treatment (Group 1) and 34 age- and sex-matched healthy subjects (Group 2) were prospectively included in the study. Demographic data and ophthalmic findings of participants were reported and analyzed. Cellular morphology was evaluated using the noncontact SM and corneal endothelial cell density (CECD) (cells/mm 2 ), polymegathism (coefficient of variation in cell size [CV], %), and pleomorphism (% hexagonal cells [Hex]) data. Anterior chamber depth and volume, iridocorneal angle degree, average keratometry diopters were also measured with corneal topography. Results: The mean age was 53.03±7.23 years (range: 38–73 years) for Group 1 and 53.15±10.7 years (range: 34–80 years) for Group 2 (p=0.958). Group 1 consisted of 11 female and 23 male patients and Group 2 included 13 female and 21 male participants (p=0.798). The mean CECD density was significantly higher in Group 1 when compared with that of Group 2 (2544.34±244.76 cells/mm 2 [range: 2126.60–3107.00 cells/mm 2 ] vs 2404.53±285.46 cells/mm 2 [range: 1839.80–2892.30 cells/mm 2 ], p=0.034). There were no significant statistical differences in the CV and Hex values between the groups (p=0.450 and p=0.717, respectively). The corneal topographic measurements were also not significantly different. Conclusion: The findings of this study revealed higher CECD values in statin users. Statins may have beneficial effects on cornea morphology.

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Evaluation of the effect of atorvastatin on corneal endothelial cells during the initial 12-month period after acute coronary syndrome

Karapapak,

Demirtola,

Kelebek

et al. 2024

Indian Journal of Ophthalmology

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Purpose: It was aimed to compare corneal endothelial changes during the initial 12-month period in which patients started using atorvastatin after a diagnosis of acute coronary syndrome (ACS). Methods: Forty-six participants (group 1) who underwent cardiac angioplasty and stenting for ACS and started using 80 mg atorvastatin in the early period were included in the study. In the study, a control group comprising 71 healthy adults (group 2) was included. These individuals did not use medication for any known systemic disease, had never taken statins, had no history of ocular surgery, and did not have any cornea-related eye diseases. Baseline and 12th month endothelial evaluations of group 1 and 2 participants were compared using specular microscopy. Results: There were 28 female and 18 male participants in group 1 and 48 female and 23 male participants in group 2 (P = 0.455). The mean baseline corneal endothelial cell density (CECD) was not significantly higher in group 1 compared to group 2 (2471.4 ± 200 cells/mm2 vs 2428.2 ± 539.8 cells/mm2, P = 0.230). When the change between baseline and 12th month CECD was examined, the decrease in group 2 was significantly different from that in group 1 (-15,2 ± 31,9 and -44,8 ± 49,6, P = 0,002). Although the percentage of hexagonal cells decreased significantly in group 2 participants, no significant change was observed in group 1 (respectively; P < 0.001, P = 0.073). The endothelial cell coefficient of variation did not differ significantly in group 1 participants over a 1-year period (P = 0.192), and a significant increase was observed in group 2 (P < 0.001). Conclusion: This study revealed that atorvastatin may have a positive effect on corneal endothelium cell density and morphology.

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The protective effect of simvastatin against ultraviolet B-induced corneal endothelial cell death

Cited by 3 publications

References 34 publications

Efficient Synthesis and Evaluation of Novel Sulfonated Dihydropyrimidinthione Derivatives for the Treatment of UV‐B‐Induced Corneal Damage

Efficient Synthesis and Evaluation of Novel Sulfonated Dihydropyrimidinthione Derivatives for the Treatment of UV‐B‐Induced Corneal Damage

Is there a relationship between statin use and corneal specular microscopy and topography findings?

Evaluation of the effect of atorvastatin on corneal endothelial cells during the initial 12-month period after acute coronary syndrome

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