The protective effect of the arginine-heparin complex under simulation of insulin-dependent diabetes

Proteolysis of Pro-Gly-Pro-Leu in Rat-Brain Hippocampus, Cerebellum, and Cortex Upon Intranasal Administration

“…Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-ProArg-Pro-Gly-Pro) that were prepared based on it exhibited several unique properties [5 -8]. The same idea was invoked to prepare the peptide Pro-Gly-Pro-Leu (PGPL), which could be used as a neuroprotector and also to prevent and treat diabetes [4].…”

“…The search for more effective and safe agents has currently focused on the possible use of endogenous biologically active compounds. In this respect, regulatory peptides, e.g., peptides belonging to the glyproline class that include the amino-acid sequences Pro-Gly, Pro-Gly-Pro, and Gly-Pro that are constantly formed in vivo during collagen degradation and synthesis, are of great interest [1][2][3][4].…”