The protective effect of the mesoporous host on the photo oxidation of fluorescent guests: a UV-Vis spectroscopy study

Miletto, Ivana; Massa, A.; Ugazio, Elena; Musso, Guido; Caputo, Giuseppe; Berlier, Gloria

doi:10.1039/c4cp01143k

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…The microenvironment plays a key role for the photophysicochemical characteristics of cyanine dyes, and thus their absorption spectra were monitored in the mixed methanol‐water solutions for demonstrating their conformations of Cypate within the nanochannels. CS–NCs exhibited the characteristic absorbance peak of Cypate at 810 nm and shoulder at 725 nm in the solutions of less than 20% methanol, while they had the characteristic absorbance peak at 785 nm in the presence of more than 30% methanol (Figure d).…”

Section: Resultsmentioning

confidence: 99%

Cyanine‐Anchored Silica Nanochannels for Light‐Driven Synergistic Thermo‐Chemotherapy

Deng

Huang

Yang

et al. 2016

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Smart nanoparticles are increasingly important in a variety of applications such as cancer therapy. However, it is still a major challenge to develop light-responsive nanoparticles that can maximize the potency of synergistic thermo-chemotherapy under light irradiation. Here, spatially confined cyanine-anchored silica nanochannels loaded with chemotherapeutic doxorubicin (CS-DOX-NCs) for light-driven synergistic cancer therapy are introduced. CS-DOX-NCs possess a J-type aggregation conformation of cyanine dye within the nanochannels and encapsulate doxorubicin through the π-π interaction with cyanine dye. Under near-infrared light irradiation, CS-DOX-NCs produce the enhanced photothermal conversion efficiency through the maximized nonradiative transition of J-type Cypate aggregates, trigger the light-driven drug release through the destabilization of temperature-sensitive π-π interaction, and generate the effective intracellular translocation of doxorubicin from the lysosomes to cytoplasma through reactive oxygen species-mediated lysosomal disruption, thereby causing the potent in vivo hyperthermia and intracellular trafficking of drug into cytoplasma at tumors. Moreover, CS-DOX-NCs possess good resistance to photobleaching and preferable tumor accumulation, facilitating severe photoinduced cell damage, and subsequent synergy between photothermal and chemotherapeutic therapy with tumor ablation. These findings provide new insights of light-driven nanoparticles for synergistic cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Cyanine‐Anchored Silica Nanochannels for Light‐Driven Synergistic Thermo‐Chemotherapy

Deng

Huang

Yang

et al. 2016

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“…MSNs were prepared by a sol-gel procedure in the presence of the surfactant cetyltrimethylammonium bromide (CTAB) as structure directing agent and functionalized by post-synthesis grafting as previously reported [50,51]. The obtained materials exhibited quasi-spherical particle morphology with an average particle size of ca.…”

Section: Resultsmentioning

confidence: 99%

Delivery of Gemcitabine Prodrugs Employing Mesoporous Silica Nanoparticles

et al. 2016

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Abstract:In this paper, mesoporous silica nanoparticles (MSNs) were studied as vehicles for the delivery of the antitumoral drug gemcitabine (GEM) and of its 4-(N)-acyl derivatives, (4-(N)-valeroyl-(C5GEM), 4-(N)-lauroyl-(C12GEM) and 4-(N)-stearoyl-gemcitabine (C18GEM)). The loading of the GEM lipophilic prodrugs on MSNs was explored with the aim to obtain both a physical and a chemical protection of GEM from rapid plasmatic metabolization. For this purpose, MSNs as such or with grafted aminopropyl and carboxyethyl groups were prepared and characterized. Then, their different drug loading capacity in relation to the nature of the functional group was evaluated. In our experimental conditions, GEM was not loaded in any MSNs, while C12GEM was the most efficiently encapsulated and employed for further evaluation. The results showed that loading capacity increased with the presence of functional groups on the nanoparticles; similarly, the presence of functional groups on MSNs' surface influenced the drug release profile. Finally, the cytotoxicity of the different preparations was evaluated and data showed that C12GEM loaded MSNs are less cytotoxic than the free drug with an activity that increased with the incubating time, indicating that all these systems are able to release the drug in a controlled manner. Altogether, the results demonstrate that these MSNs could be an interesting system for the delivery of anticancer drugs.

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“…MCM-41 nanoparticles (MCM-41 NPs) were synthesized according to the procedure by Miletto et al [ 33 ]. In a typical synthesis, 1 g of CTAB (hexadecyltrimethylammonium bromide) and 3.5 mL of 2M NaOH were added to 480 mL of deionized water in a three-necked flask.…”

Section: Methodsmentioning

confidence: 99%

Adsorption Features of Various Inorganic Materials for the Drug Removal from Water and Synthetic Urine Medium: A Multi-Technique Time-Resolved In Situ Investigation

et al. 2021

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Pharmaceutical active compounds, including hundreds of different substances, are counted among the emerging contaminants in waterbodies, whose presence raises a growing concern for the ecosystem. Drugs are metabolized and excreted mainly through urine as an unchanged active ingredient or in the form of metabolites. These emerging contaminants are not effectively removed with the technologies currently in use, making them a relevant environmental problem. This study proposes the treatment of urine and water at the source that can allow an easier removal of dissolved drugs and metabolites. The treatment of synthetic urine, with dissolved ibuprofen as a model compound, by adsorption, using various classes of inorganic materials, such as clays, hierarchical zeolites and ordered mesoporous silica (MCM-41), is presented. A multi-technique approach involving X-ray powder diffraction, solid-state NMR, UV-Vis and Raman spectroscopies was employed to investigate the adsorption process in inorganic adsorbents. Moreover, the uptake, the ensuing competition, the efficiency and selectivity as well as the packing of the model compound in ordered mesoporous silica during the incipient wetness impregnation process were all thoroughly monitored by a novel approach, involving combined complementary time-resolved in situ 1H and 13C MAS NMR spectroscopy as well as X-ray powder diffraction.

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The protective effect of the mesoporous host on the photo oxidation of fluorescent guests: a UV-Vis spectroscopy study

Cited by 8 publications

References 28 publications

Cyanine‐Anchored Silica Nanochannels for Light‐Driven Synergistic Thermo‐Chemotherapy

Cyanine‐Anchored Silica Nanochannels for Light‐Driven Synergistic Thermo‐Chemotherapy

Delivery of Gemcitabine Prodrugs Employing Mesoporous Silica Nanoparticles

Adsorption Features of Various Inorganic Materials for the Drug Removal from Water and Synthetic Urine Medium: A Multi-Technique Time-Resolved In Situ Investigation

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