The protective effect of the Cornus mas fruits (cornelian cherry) on hypertriglyceridemia and atherosclerosis through PPARα activation in hypercholesterolemic rabbits

Sozański, Tomasz; Kucharska, Alicja Z.; Szumny, Antoni; Magdalan, Jan; Bielska, Katarzyna; Merwid-Ląd, Anna; Woźniak, Anna; Dzimira, Stanisław; Piórecki, Narcyz; Trocha, Małgorzata

doi:10.1016/j.phymed.2014.09.005

Cited by 89 publications

(78 citation statements)

References 38 publications

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“…Ursolic acid ( 112 ) may ameliorate colitis by regulating NF-κB and MAPK signaling pathways via the inhibition of LPS binding to toll-like receptors 4 (TLR4) on immune cells (Jang et al, 2014). Taking into consideration a wide range of ingredients and general mechanisms responsible for induction or prevention of inflammation, in vitro results fit to conclusions obtained from animal experiments and a clinical study (Sung et al, 2009; Sozanski et al, 2014, 2016; Moldovan et al, 2016). In particular, cornuside ( 6 ) was indicated as an immunomodulatory dogwood-derived compound in a model of sepsis in rats (Jiang et al, 2009).…”

Section: Similarities and Differences Of Pharmacological Effects Or Bsupporting

confidence: 72%

“…Both in C. mas and C. officinalis pelargonidin 3- O -galactoside ( 53 ), cyanidin 3- O -galactoside ( 58 ), and delphinidin 3- O -galactoside ( 64 ) were detected and quantified. Pelargonidin 3- O -galactoside ( 53 ) (1.62 mg/g) and cyanidin 3- O -galactoside ( 58 ) (1.66 mg/g) have been noted as the most abundant anthocyanins of C. mas fresh fruit (Jayaprakasam et al, 2006; Vareed et al, 2006; Sozanski et al, 2014; Kucharska et al, 2015). The amount of pelargonidin 3- O -galactoside ( 53 ) in fruit of C. officinalis (0.78 mg/g) was approximately half of the concentration determined in fruit of C. mas .…”

Section: Similarities and Differences In The Chemical Composition Of mentioning

confidence: 99%

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Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times. Cornus mas (cornelian cherry) is native to southern Europe and southwest Asia, whereas C. officinalis (Asiatic dogwood, cornel dogwood) is a deciduous tree distributed in eastern Asia, mainly in China, as well as Korea and Japan. Based on the different geographic distribution of the closely related species but clearly distinct taxa, the ethnopharmacological use of C. mas and C. officinalis seems to be independently originated. Many reports on the quality of C. mas fruits were performed due to their value as edible fruits, and few reports compared their physicochemical properties with other edible fruits. However, the detailed phytochemical profiles of C. mas and C. officinalis, in particular fruits, have never been compared. The aim of this review was highlighting the similarities and differences of phytochemicals found in fruits of C. mas and C. officinalis in relation to their biological effects as well as compare the therapeutic use of fruits from both traditional species. The fruits of C. mas and C. officinalis are characterized by the presence of secondary metabolites, in particular iridoids, anthocyanins, phenolic acids and flavonoids. However, much more not widely known iridoids, such as morroniside, as well as tannins were detected particularly in fruits of C. officinalis. The referred studies of biological activity of both species indicate their antidiabetic and hepatoprotective properties. Based on the available reports antihyperlipidemic and anticoagulant activity seems to be unique for extracts of C. mas fruits, whereas antiosteoporotic and immunomodulatory activities were assigned to preparations of C. officinalis fruits. In conclusion, the comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood. Thus, these phytochemicals are considered the important factor determining the biological activity and justifying the use of C. mas and C. officinalis in the traditional European and Asiatic medicine.

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Section: Similarities and Differences Of Pharmacological Effects Or Bsupporting

confidence: 72%

Section: Similarities and Differences In The Chemical Composition Of mentioning

confidence: 99%

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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“…The plant material was authenticated by Professor Jakub Dolatowski, and the voucher specimen (12402) was deposited at the Herbarium of Arboretum and Institute of Physiography in Bolestraszyce, Poland. The polyphenolic and loganic acid iridoid fractions were prepared in the Department of Fruit, Vegetable and Cereals Technology at Wroclaw University of Environmental and Life Science, according to the procedure described in our previous publication [29] and patent [29]. Ripe Cornelian cherries were washed, frozen, and stored at −20°C until processing.…”

Section: Methodsmentioning

confidence: 99%

Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure

Szumny

Sozański

Kucharska

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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One of the most common diseases of old age in modern societies is glaucoma. It is strongly connected with increased intraocular pressure (IOP) and could permanently damage vision in the affected eye. As there are only a limited number of chemical compounds that can decrease IOP as well as blood flow in eye vessels, the up-to-date investigation of new molecules is important. The chemical composition of the dried Cornelian cherry (Cornus mas L.) polar, iridoid-polyphenol-rich fraction was investigated. Loganic acid (50%) and pelargonidin-3-galactoside (7%) were found as the main components. Among the other constituents, iridoid compound cornuside and the anthocyans cyanidin 3-O-galactoside, cyanidin 3-O-robinobioside, and pelargonidin 3-O-robinobioside were quantified in the fraction. In an animal model (New Zealand rabbits), the influence of loganic acid and the polyphenolic fraction isolated from Cornelian cherry fruit was investigated. We found a strong IOP-hypotensive effect for a 0.7% solution of loganic acid, which could be compared with the widely ophthalmologically used timolol. About a 25% decrease in IOP was observed within the first 3 hours of use.

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“…Hypercholesterolemic rabbits were also used as a model by Sozański et al [172] to evaluate the effects of the components of cornelian cherries on lipid metabolism, augmentation of protein PPARα, lipid peroxidation and antioxidants. During 60 days, rabbits were exposed to standard diet plus 1% of cholesterol.…”

Section: Introductionmentioning

confidence: 99%

Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies

et al. 2016

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Cardiovascular diseases (CVD) are an important cause of death worldwide. Anthocyanins are a subgroup of flavonoids found in berries, flowers, fruits and leaves. In epidemiological and clinical studies, these polyphenols have been associated with improved cardiovascular risk profiles as well as decreased comorbidities. Human intervention studies using berries, vegetables, parts of plants and cereals (either fresh or as juice) or purified anthocyanin-rich extracts have demonstrated significant improvements in low density lipoproteins oxidation, lipid peroxidation, total plasma antioxidant capacity, and dyslipidemia as well as reduced levels of CVD molecular biomarkers. This review discusses the use of anthocyanins in animal models and their applications in human medicine, as dietary supplements or as new potent drugs against cardiovascular disease.

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The protective effect of the Cornus mas fruits (cornelian cherry) on hypertriglyceridemia and atherosclerosis through PPARα activation in hypercholesterolemic rabbits

Cited by 89 publications

References 38 publications

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure

Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies

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