The protective effects of apocynin on ionizing radiation-induced intestinal damage in rats

Çağın, Yasir Furkan; Parlakpınar, Hakan; Polat, Alaadin; Vardı, Nigar; Atayan, Yahya; Erdogan, M A; Ekici, Kemal; Yıldız, Azibe; Sarıhan, Mehmet Ediz; Aladag, Hulya

doi:10.3109/03639045.2015.1052080

Cited by 25 publications

(17 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In GIS, urological, and gynaecological malignancies, RT is usually applied to the abdominal and pelvic regions. Upon exposure to radiation in these areas, inflammatory cells are activated and, as a result, there is mucosal damage, destruction of crypt cells, a decrease in the number and size of villous structures, and an increase in ulcerative and necrotic areas (6)(7)(8). The most important mechanism in the emergence of this damage is an increase in free radicals associated with RT.…”

Section: Discussionmentioning

confidence: 99%

“…Although the mechanism behind the above phenomena is not yet fully understood, reactive oxygen species that emerge in the mitochondria during radiation are thought to be harmful to proteins, lipids, and nucleic acids (6,9). In previous studies, chemical agents and oral nutritional supplements were used to reduce these complications associated with RT (1,3,7,10,11).…”

Section: Introductionmentioning

confidence: 99%

“…During radiation exposure, inflammatory cells are activated, causing mucosal damage. Several studies have shown that, in the pathology associated with RT, there is crypt cell destruction along the GIS tract, a decrease in the number and size of villous structures, and an increase in ulcerative and necrotic areas (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation

Pişkin¹,

Aydın²,

Baş³

et al. 2018

Haseki

View full text Add to dashboard Cite

Radyasyona Bağlı İntestinal Hasarda Quercetin'in Koruyucu EtkisiAim: The aim of this study was to evaluate the protective use of quercetin in a rat model of radiation-induced enteritis and colitis.Methods: Twenty four adult rats were randomly divided into four groups. Group SHAM was given only physiological saline, group QUER was given quercetin 50 mg/kg for 15 days, group RAD was given only irradiation and group QUER+RAD was given quercetin 50 mg/kg, and then irradiated. Twenty four hours after the exposure to radiation, all rats were euthanized for the evaluation of the ileum and colon morphology and biochemical measurements. Results:Compared with the SHAM group, the serum malondialdehyde (MDA) level was significantly higher in group RAD (p=0.004) and was significantly decreased in group QUER+RAD (p=0.015). The MDA levels in the ileum and colon tissues were significantly higher in group RAD (p=0.004 and p=0.002, respectively), while treatment with quercetin significantly reduced lipid peroxidation in both tissues in group QUER+RAD (p=0.015 and p=0.009, respectively). Compared with the control group, the serum total antioxidant status (TAS) level was significantly lower in Group RAD (p=0.002) and was significantly increased in group QUER+RAD (p=0.009). TAS in the ileum and colon tissues were significantly lower in group RAD (p=0.002 and p=0.002) and were significantly higher in both tissues in group QUER+RAD (p=0.002 and p=0.002, respectively). Conclusion:This study confirmed that, in the model of radiationinduced ileitis and colitis in rats, quercetin effectively decreased oxidative stress and inflammatory damage to both ileum and colon tissues.Keywords: Quercetin, intestine damage, oxidative stress, radiation, rat Amaç: Bu çalışmanın amacı rat modelinde radyasyona bağlı oluşan enterit ve kolit tedavisinde quercetin'in koruyucu rolünü değerlendirmektir. Yöntemler:Yirmi dört yetişkin rat randomize olarak dört gruba ayrıldı. Group SHAM'a sadece salin, grup QUER'e 15 gün boyunca 50 mg/ kg quercetin, grup RAD'a sadece radyasyon ve grup QUER+RAD'a 15 gün boyunca 50 mg/kg quercetin ardından radyasyon uygulandı. Radyasyon maruziyetinden 24 saat sonra ileum ve kolon morfolojisi ve biyokimyasal parametrelerin değerlendirilmesi için ratlara ötenazi uygulandı. Bulgular: SHAM grubuyla karşılaştırıldığında, serum malondialdehit (MDA) seviyesi grup RAD'da istatistiksel olarak anlamlı derecede yüksek (p=0,004) ve grup QUER+RAD'da düşük bulundu (p=0,015). İleum ve kolon dokularındaki MDA seviyesi grup RAD'da anlamlı olarak daha yüksek (sırasıyla; p=0,004 ve p=0,002) idi. Grup QUER+RAD'da ise her iki dokuda azalmış olarak bulundu (sırasıyla; p=0,015 ve p=0,009). Kontrol grubuyla karşılaştırıldığı zaman, serum total antioksidan kapasite (TAK) seviyesi grup RAD'da istatistiksel olarak anlamlı derecede düşük (p=0,002) ve grup QUER+RAD'da ise yüksek bulundu (p=0,009). İleum ve kolon dokularındaki TAK seviyesi grup RAD'da istatistiksel olarak anlamlı derecede düşük iken (sırasıyla; p=0,002 ve p=0,002), grup QUER+RAD'da ise her iki ...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation

Pişkin¹,

Aydın²,

Baş³

et al. 2018

Haseki

View full text Add to dashboard Cite

show abstract

“…Yapı-lan çalışmalarda aposininin NOX inhibisyonu yaparak inflamasyon, granülasyon oluşumu ve skar dokusu oluşumunu azalttığı saptanmıştır. 13,25 Yakın zamanda aposinin ile yaptığımız bir deneysel çalış-mada, proliferatif vitreoretinopati (PVR) gelişimini durdurmada etkili olduğu saptanmıştır.…”

Section: Gereç Ve Yöntemlerunclassified

“…9 Aposinin, birçok alanda çalışmalarda kullanılmış ve çeşitli nedenlerden kaynaklanan oksidatif hasarların azaltılmasında etkili bulunmuştur. [10][11][12][13][14] Bu çalışmada, yeni bir travmatik katarakt modeli oluşturarak, aposinin molekülünün travmatik katarakt üzerine olan etkisinin incelenmesi amaç-lanmıştır.…”

unclassified

Investigation of the Effect of Apocynin on Experimental Traumatic Cataract Model

Polat¹,

Özer²,

Parlakpınar³

et al. 2017

Turkiye Klinikleri J Ophthalmol

View full text Add to dashboard Cite

Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes

et al. 2016

View full text Add to dashboard Cite

The aim of the current study was to evaluate the effect of apocynin (APO) on the development of proliferative vitreoretinopathy (PVR). New Zealand-type male rabbits were randomly grouped into three as follows: (1) Sham group rabbits which were applied intraperitoneal (i.p.) vehicle without PVR; (2) PVR group rabbits where PVR was created and an i.p. vehicle was administered for 21 successive days; (3) PVR + APO group rabbits where PVR was created and i.p. APO was administered for 21 successive days. Fundus examination was conducted with an indirect ophthalmoscope before starting the experiments and at each visit afterwards. At the end of the work, the rabbits were sacrificed under high-dose anesthesia and then eye tissues were taken for histopathological analyses. In the PVR + APO group, histopathologic and ophthalmoscopic examination revealed significant decrease in PVR formation. As the result, it has been observed that APO at least partially inhibits PVR formation.

show abstract

The protective effects of apocynin on ionizing radiation-induced intestinal damage in rats

Abstract: Our study shows that APO treatment before radiation improves radiation induced colonic injury in rats, by decreasing oxidative stress and apoptosis.

Cited by 25 publications

References 48 publications

Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation

Protective Effects of Quercetin on Intestinal Damage Caused by Ionizing Radiation

Investigation of the Effect of Apocynin on Experimental Traumatic Cataract Model

Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes

Contact Info

Product

Resources

About