The protective effects of beta-carotene against ischemia/reperfusion injury in rat ovarian tissue

Karamese, Selina Aksak; Toktay, Erdem; Ünal, Deniz; Selli, Jale; Karameşe, Murat; Malkoç, Ismail

doi:10.1016/j.acthis.2015.07.006

Cited by 52 publications

(25 citation statements)

References 33 publications

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“…Finally, Aksak Karamese et al reported that betacarotene, which is a kind of carotenoids, exerts protective effects on experimentally induced ovarian I/R injury. In this rat study, biochemical results (MDA, GSH) and histopathological evaluation after betacarotene administration were similar to those in our study (39).…”

Section: Discussionsupporting

confidence: 90%

The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats

Turkler¹,

Kulhan²,

Ata³

et al. 2018

BLL

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OBJECTIVES: The aim of our study is to investigate biochemical and histopathological effects of lutein on the ovarian ischemia-reperfusion (I/R) injury in rats. BACKGROUND: Reactive oxygen species and cytokines have a very important role in the pathogenesis of I/R injury. Lutein and its derivatives may show an anti-infl ammatory effect in relation to the decrease in infl ammatory cytokines and increase in antioxidant enzymes. METHODS: Wistar albino female rats were randomly divided into three groups before surgery as follows: I/R group (IRG; n = 6), 1 mg/kg lutein + I/R group (LIRG; n = 6), and a healthy control group scheduled for a sham operation (SG; n = 6). The condition of ovarian ischemia was created by vascular clips. After two hours, the ovary was reperfused. Then, cyclooxygenase-1, cyclooxygenase-2, malondialdehyde and total glutathione levels were examined in ovary tissues of rats. RESULTS: As the results of our study demonstrated, in ovarian tissues of animals after I/R, there was an increase in the levels of malondialdehyde and cyclooxygenase-2, while total glutathione and cyclooxygenase-1 were decreased. At the same time, it has been observed however that these ratios are reversed in the LIRG group (p < 0.05). CONCLUSION: Lutein ameliorates the I/R-induced ovarian injury in rats by its antioxidative and anti-infl ammatory activities (Fig. 2, Ref. 39). Text in PDF www.elis.sk.

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Section: Discussionsupporting

confidence: 90%

The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats

Turkler¹,

Kulhan²,

Ata³

et al. 2018

BLL

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“…In an elegant study, the possible effect of BETA on oocyte maturation under oxidative stress and the involved underlying mechanisms was explored [46]; while ROS inhibited oocyte development/maturation and parthenogenetic activation, BETA actions vanished such deleterious mechanisms, enhancing ovarian activation and development. Additionally, the protective BETA effects against the oxidative damage in ovarian tissue facing ischemia throughout different expression patterns of the antioxidant enzymes superoxidase dismutase (SOD) and glutathione (GSH), plus the malondialdehyde (MDA) level, which is the end result of lipid peroxidation, have been proposed [47]. Moreover, BETA supply not only restored actin expression, cortical granule-free domain formation, mitochondria homogeneous distribution and nuclear maturation [47] but also reduced both ROS formation and cell apoptosis [1]; such results point out to BETA as an improver of both ovarian function and oocyte quality.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the protective BETA effects against the oxidative damage in ovarian tissue facing ischemia throughout different expression patterns of the antioxidant enzymes superoxidase dismutase (SOD) and glutathione (GSH), plus the malondialdehyde (MDA) level, which is the end result of lipid peroxidation, have been proposed [47]. Moreover, BETA supply not only restored actin expression, cortical granule-free domain formation, mitochondria homogeneous distribution and nuclear maturation [47] but also reduced both ROS formation and cell apoptosis [1]; such results point out to BETA as an improver of both ovarian function and oocyte quality. Unquestionably, the specific site of action of BETA-supply thru the HPG axis will not be recognized without additional enquiries.…”

Section: Discussionmentioning

confidence: 99%

Precision Betacarotene Supplementation Enhanced Ovarian Function and the LH Release Pattern in Yearling Crossbred Anestrous Goats

Lopez-Flores

Meza-Herrera

Marı́n

et al. 2020

Animals

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The possible out-of-season effect of beta-carotene supplementation on ovulation rate (OR), antral follicles (AFN), and total ovarian activity (TOA = OR + AFN) as related to the LH release pattern in yearling anestrous goats was evaluated. In late April, Alpine-Saanen-Nubian x Criollo goats (n = 22, 26 N) were randomly allotted to: (1) Beta-carotene (BETA; n = 10, orally supplemented with 50 mg/goat/d; 36.4 ± 1.07 kg live weight (LW), 3.5 ± 0.20 units, body condition score (BCS) or (2) Non-supplemented (CONT; n = 12, 35.2 ± 1.07 kg LW, 3.4 ± 0.2 units BCS). Upon estrus synchronization, an intensive blood sampling (6 h × 15 min) was accomplished in May for LH quantifications; response variables included (pulsatility-PULSE, time to first pulse-TTFP, amplitude-AMPL, nadir-NAD and area under the curve-AUC). Thereafter, an ultrasonography scanning was completed to assess OR and AFN. The Munro algorithm was used to quantify LH pulsatility; if significant effects of time, treatment or interaction were identified, data were compared across time. Neither LW nor BCS (p > 0.05) or even the LH (p > 0.05); PULSE (4.1 ± 0.9 pulses/6 h), NAD (0.47 ± 0.13 ng) and AUC (51.7 ± 18.6 units) differed between treatments. Nonetheless, OR (1.57 vs. 0.87 ± 0.18 units) and TOA (3.44 vs. 1.87 ± 0.45 units) escorted by a reduced TTFP (33 vs. 126 ± 31.9 min) and an increased AMPL (0.55 vs. 0.24 ± 0.9 ng), favored to the BETA supplemented group (p < 0.05), possibly through a GnRH-LH enhanced pathway and(or) a direct effect at ovarian level. Results are relevant to speed-up the out-of-season reproductive outcomes in goats while may embrace translational applications.

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“…Guney et al 29 demonstrated reduced lymphocyte and eosinophil infiltration in endometrial stroma by vitamins C and E treatment in fluoride toxicity. Aksak et al 30 observed betacarotene provides a partial recovery on intense hemorrhagic areas in the cortex, necrotic cells in the medulla and PMNL adhesion to vascular endothelia in ischemia-reperfusion models of rat ovaries. These results are in accordence with our findings.…”

Section: Histopatlogical Examinationmentioning

confidence: 99%

“…Yet, we are not aware of any study on effects of ML on the ovarian and uterine tissues. In literature, it was shown that similar antioxidants such as vitamin E, vitamin C and beta-caratone protects uterine and ovarian tissues from oxidative injuries to uterine and ovarian tissues 29,30 . Guney et al 29 demonstrated reduced lymphocyte and eosinophil infiltration in endometrial stroma by vitamins C and E treatment in fluoride toxicity.…”

Section: Histopatlogical Examinationmentioning

confidence: 99%

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

et al. 2016

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PURPOSE:To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS:Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS:The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION:The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.

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The protective effects of beta-carotene against ischemia/reperfusion injury in rat ovarian tissue

Cited by 52 publications

References 33 publications

The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats

The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats

Precision Betacarotene Supplementation Enhanced Ovarian Function and the LH Release Pattern in Yearling Crossbred Anestrous Goats

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

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