•The protective effects of omega-3 fatty acids on rat testicular tissue

Zararsız, İsmail; Kuş, İlter; Davarci, Mursel; Kuş, Murat Abdulgani; Kaman, Dilara; Sarsılmaz, Mustafa

doi:10.5798/diclemedj.0921.2011.04.0054

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Fatty acid composition of the spermatozoa may be an important determinant of fertility [22]. In a study concluded that ω-3 fatty acid had favorable effects in rat testis tissue by preventing oxidative damage and increasing the level of testosterone [23]. A, C and E): Oxidative stress is the increase of the rate of cellular damage triggered by oxygen and oxygen-based oxidants known as reactive oxygen species.…”

Section: The Relationship Of Body-mass Index and Infertilitymentioning

confidence: 99%

The Relationship between Infertility and Nutrition

Şanlıer¹,

To²

2018

Journal of Nutrition and Health Sciences

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The problem of infertility could arise from the woman, the man or both of them and sometimes it could stem from without a reason. The reasons of male infertility could be varicocele, idiopathic infertility, obstruction, undescended testis, immunological mechanisms, ejaculation disorder, testicular insufficiency, medicine-radiation effect, endocrine disorders such as diabetes, excessive consumption of alcohol, smoking and environmental toxins such as pesticides and lead. It is also believed that societies, obesity, lack of nutrition and ways of spending time for example excessive use of mobile phones, laptop computers and sauna, etc., as for women, age, smoking, excessive consumption of alcohol, having a skinny or overweight body and having been exposed to physical or emotional stress resulting in amenorrhea might be the causes of infertility. The increase in infertility prevalence draws attention to the effects of factors such as life style, nutritional habits and environmental factors. Male infertility emerges from mostly as a result of the relationship between oxidative stress and antioxidants, whereas, female infertility results from mostly as a result of insulin resistance and the effects of PCOS and BMI. Therefore, in this review, the relationship between nutrition and infertility which is commonly seen in men and women is studied.

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Section: The Relationship Of Body-mass Index and Infertilitymentioning

confidence: 99%

The Relationship between Infertility and Nutrition

Şanlıer¹,

To²

2018

Journal of Nutrition and Health Sciences

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“…Group III: Omega-3 group: rats of this group were orally received omega-3 at a dose 400 mg/kg body weight/day 11 .…”

Section: Experimental Animal and Treatmentmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:The present study was designed to evaluate the protective effect of omega-3 against β-cyfluthrin (β-cyf)-induced neurotransmitters' impairment, oxidative damage, testicular toxicity and genotoxicity. Adult male Wistar rats were divided equally into four groups: Group (I): Control, Group (II): β-cyf (5 mg/kg body weight/day), Group (III): omega-3 (400 mg/kg body weight/da y) + β-cyf (5 mg/kg body weight/day), Group (IV): omega-3 (400 mg/kg body weight/day). β-cyf's treatment for 8 weeks inhibited the activities of AChE, DA, LDH, total ATPase and Na + /K + ATPase. Also, β-cyf resulted in an increase in oxidative stress as indicated by elevations in the levels of MDA and NO while, the levels of TAC, thiol content and TP were decreased in brain and testis. Sperm count, sperm motility and testosterone levels were reduced while, sperm abnormalities, FSH and LH levels were increased in β-cyf-treated group. Also, β-cyf administration led to a significant increase in TNFα, IL-6 and APP mRNA expressions. In addition, β-cyf caused histopathological alterations in brain and testis. The present results showed that omega-3 could improve all the measured parameters. In conclusion, omega-3 could exhibit protective effects against β-cyf induced neurological and testicular damage.

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Short term chronic toxicity of tributyltin on the testes of adult albino rats and the possible protective role of omega-3

et al. 2020

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The declining rate of male fertility is a growing concern. Tributyltin (TBT) is a well-known endocrine disruptor (ED), that induces imposex in female gastropods and is widely used in various industrial applications. The aim of this study was to evaluate the toxic effects of TBT on the testes of adult albino rats and the possible role of omega-3. Forty two adult male albino rats were divided into five groups; control group (Group I) and four experimental groups: omega-3 treated group, TBT treated group, TBT & omega-3 treated group and follow up group. At the end of the study, the rats were subjected to biochemical, histological, immunohistochemical staining for Ki-67 and seminal examinations. Our results clarfied that TBT induced a significant decrease in testosterone, FSH, LH and serum glutathione peroxidase levels and a significant increase in the serum Malondialdehyde as compared to the control group. Tributyltin induced disorganization and shrinkage of seminiferous tubules, apoptosis, cellular damage and marked reduction in the germinal epithelium. A significant decrease in the cell proliferation and arrested spermatogenesis were also detected. Seminal analysis of TBT group showed a significant affection of all parameters as compared to other groups. Omega-3 ameliorated all of these hazardous effects. Follow up group still showed toxic effects. In conclusion, TBT has a toxic effect on the testis. Increased testicular oxidative stress, cellular damage and arrest of spermatogenesis with attenuation in antioxidant defenses are all contributing factors. Omega-3 can protect against TBT induced reproductive toxicity.

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•The protective effects of omega-3 fatty acids on rat testicular tissue

Cited by 4 publications

References 19 publications

The Relationship between Infertility and Nutrition

The Relationship between Infertility and Nutrition

Untitled

Short term chronic toxicity of tributyltin on the testes of adult albino rats and the possible protective role of omega-3

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