The protective effects of sophocarpine on sepsis-induced cardiomyopathy

Fu, Yang Xin; Zhang, Hongjin; Zhou, Wei; Lai, Ze-qun; Dong, Yi-Fei

doi:10.1016/j.ejphar.2023.175745

Cited by 8 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SOP is a type of a tetracyclic quinolizidine alkaloid extracted from the traditional chinese medicine sophora flavescens 17 , which exerts various biological effects in vivo like anti-nociceptive, anti-inflammatory, anti-oxidative stress, neuroprotective, immune regulatory functions, and anti-tumor 12 . Our previous research revealed that SOP can alleviate heart injury induced by lipopolysaccharide, and further found that SOP exerts its cardioprotective effect by inhibiting inflammation, apoptosis, oxidative stress and autophagy 13 . So we speculate that SOP can also alleviate DOX-induced heart injury, and found that SOP could alleviate DOX-induced heart injury by inhibiting oxidative stress and apoptosis (Fig.…”

Section: Discussionmentioning

confidence: 92%

“…Sophocarpine (SOP), a quinolizidine tetracyclic alkaloid, which was extracted from sophora flavescens, has been suggested to have anti-nociceptive, anti-inflammatory, anti-oxidative stress, neuroprotective, immune regulatory functions, and anti-tumor activities 12 . Our previous study have showed that SOP has a protective effect on sepsis-induced heart injury 13 . However, it is unclear whether SOP exerts a cardioprotective effect against DOX-induced heart injury.…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Sophocarpine alleviates doxorubicin-induced heart injury by suppressing oxidative stress and apoptosis

Zhang,

Fu,

Zhang

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

Doxorubicin (DOX) is an effective anti-tumor drug accompanied with many side effects, especially heart injury. To explore what effects of sophocarpine (SOP) on DOX-induced heart injury, this study conducted in vivo experiment and in vitro experiment, and the C57BL/6J mice and the H9C2 cells were used. The experimental methods used included echocardiography, enzyme-linked immunosorbent assay (ELISA), dihydroethidium (DHE) staining, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, western blotting and so on. Echocardiography showed that SOP alleviated DOX-induced cardiac dysfunction, as evidenced by the improvements of left ventricle ejection fraction and left ventricle fractional shortening. DOX caused upregulations of creatine kinase (CK), creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH), while SOP reduced these indices. The relevant stainings showed that SOP reversed the increases of total superoxide level induced by DOX. DOX also contribute to a higher level of MDA and lower levels of SOD and GSH, but these changes were suppressed by SOP. DOX increased the pro-oxidative protein level of NOX-4 while decreased the anti-oxidative protein level of SOD-2, but SOP reversed these effects. In addition, this study further discovered that SOP inhibited the decreases of Nrf2 and HO-1 levels induced by DOX. The TUNEL staining revealed that SOP reduced the high degree of apoptosis induced by DOX. Besides, pro-apoptosis proteins like Bax, cleaved-caspase-3 and cytochrome-c upregulated while anti-apoptosis protein like Bcl-2 downregulated when challenged by DOX, but them were suppressed by SOP. These findings suggested that SOP could alleviate DOX-induced heart injury by suppressing oxidative stress and apoptosis, with molecular mechanism activating of the Nrf2/HO-1 signaling pathway.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 95%

Sophocarpine alleviates doxorubicin-induced heart injury by suppressing oxidative stress and apoptosis

Zhang,

Fu,

Zhang

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…It effectively inhibited LPS-induced cardiac inflammation, oxidative stress, apoptosis, and autophagy. A follow-up mechanistic study suggested that sophocarpine protects cells by inhibiting TLR-4/NF-κB while activating the Nrf2/HO-1 signaling pathway ( Fu et al, 2023 ). These studies provide evidence that sophocarpine has cardioprotective effects on diverse forms of damage by mitigating inflammation, attenuating oxidative stress, and engaging multiple signaling pathways and mechanisms.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A review on the pharmacology, pharmacokinetics and toxicity of sophocarpine

Wei,

Xiao,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Sophocarpine is a natural compound that belongs to the quinolizidine alkaloid family, and has a long history of use and widespread distribution in traditional Chinese herbal medicines such as Sophora alopecuroides L., Sophora flavescens Ait., and Sophora subprostrata. This article aims to summarize the pharmacology, pharmacokinetics, and toxicity of sophocarpine, evaluate its potential pharmacological effects in various diseases, and propose the necessity for further research and evaluation to promote its clinical application. A large number of studies have shown that it has anti-inflammatory, analgesic, antiviral, antiparasitic, anticancer, endocrine regulatory, and organ-protective effects as it modulates various signaling pathways, such as the NF-κB, MAPK, PI3K/AKT, and AMPK pathways. The distribution of sophocarpine in the body conforms to a two-compartment model, and sophocarpine can be detected in various tissues with a relatively short half-life. Although the pharmacological effects of sophocarpine have been confirmed, toxicity and safety assessments and reports on molecular mechanisms of its pharmacological actions have been limited. Given its significant pharmacological effects and potential clinical value, further research and evaluation are needed to promote the clinical application of sophocarpine.

show abstract