The protective effects of taurine on experimental acute pancreatitis in a rat model

Abstract

The aim of this study was to investigate the protective effects of taurine (Tau) on experimental acute pancreatitis (AP) in a rat model by measuring cytokines and oxidant stress markers. Forty rats were randomly divided into four groups: sham, AP, Tau and AP + Tau. AP was induced with sodium taurocholate. No treatment was given to the AP. All rats were killed 5 days later. Pancreatic tissues of rats and blood samples were obtained. Tau treatment significantly decreased serum amylase activity (p < 0.001), total injury score (p < 0.001), malondialdehyde levels (p < 0.001) and myeloperoxidase (MPO) activity (p < 0.001). There was no significant difference between the Tau and AP + Tau groups in serum and pancreatic tumor necrosis factor-α, interleukin (IL)-1β and IL-6 levels (p = 1.000). Histopathologic scores in the AP + Tau and Tau groups were significantly lower compared with the AP group (both p < 0.001). These results showed that Tau reduces lipid peroxidation, amylase and MPO activities and the concentrations of proinflammatory cytokines secondary to AP and also increases superoxide dismutase and glutathione peroxidase activities in rats with sodium taurocholate-induced AP. It also has a marked ameliorative effect at histopathologic lesions. With these effects, Tau protects the cells from oxidative damage, reduces inflammation and promotes regression of pancreatic damage.

Phase IV Prospective Clinical Study to Evaluate the Effect of Taurine on Liver Function in Postsurgical Adult Patients Requiring Parenteral Nutrition

“…However, taurine supplementation of PN solutions for therapeutic anti‐inflammation has not been thoroughly investigated. Studies using experimental models suggest a beneficial effect of taurine treatment on inflammation 34 – 40 . In our study, however, the presence of taurine in the PN solution did not seem to exert an effect on the approximately 30% of postsurgical patients who showed increased values of inflammation markers at day 5 of PN.…”

“…Studies using experimental models suggest a beneficial effect of taurine treatment on inflammation. [34][35][36][37][38][39][40] In our study, however, the presence of taurine in the PN solution did not seem to exert an effect on the approximately 30% of postsurgical patients who showed increased values of inflammation markers at day 5 of PN. Taurine-containing nutritional supplements have been shown to reduce markers of inflammation in healthy individuals.…”

Antioxidant Activity of Syringic Acid Prevents Oxidative Stress in l-arginine–Induced Acute Pancreatitis: An Experimental Study on Rats

“…2 The balance between ROS/RNS-generating enzymes and scavenger enzyme systems can be upset in a number of pathologic conditions, such as systemic lupus erythematosus, diabetes mellitus, otitis media, rheumatoid arthritis, Behçet disease, [17][18][19][20][21] endothelial dysfunction, atherosclerosis, hypertension, 22 degenerative diseases, inflammatory bowel disease, and pancreatitis. 2,23 Unchecked ROS/RNS generation leads to oxidative damage and activation of reactive signaling cascades, and thus ROS scavenging therapy has been proposed as a potential treatment for disorders related to excessive ROS/RNS generation. 2 In the study we found that although pancreatic tissue TOS levels, OSI, and LOOH levels were significantly increased in the AP group compared with the control group, TAS andÀSH group levels were significantly decreased.…”

“…In addition, the finding that SA provides protective effects against APinduced oxidative stress is consistent with previous reports on the protective effects of SA. 14,16,23 Cells are equipped with several antioxidant defense systems, including total ÀSH groups, to detoxify the endogenous and exogenous oxidative challenges during aerobic metabolism or when they encounter stress-inducing agents. 26,27 Separate evaluation of the levels under imbalanced conditions or evaluation of these levels for detection of the protective effects of several substances on living organisms may not lead to a definitive conclusion when assessing oxidative balance or imbalance.…”

Novel protective role of curcumin and taurine combination against experimental hepatocarcinogenesis

“…Furthermore, it was shown to protect against genotoxicity induced by anti-neoplastic drugs in somatic and germ tissues, and may be of therapeutic potential in alleviating the risk of secondary tumors following chemotherapy (18,19). Taurine also reduced lipid peroxidation and the levels of proinflammatory cytokines in a rat model of acute pancreatitis by increasing the levels of superoxide dismutase and glutathione peroxidase (20). In addition, taurine has been shown to exert an anti-cancer effect by inducing the apoptosis of cancer cells, although the underlying molecular mechanism of this effect is not well understood (21).…”