The protective effects of trimetazidine against ovary ischemia–reperfusion injury via the TLR4/Nf‐kB signal pathway

Ozturk, Aykut; Topçu, Atilla; Deniz, Esra; Öztürk, Seda Duman; Arpa, Medeni; Yilmaz, Eda Kutlu

doi:10.1002/jbt.23114

Cited by 6 publications

(2 citation statements)

References 48 publications

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“…Based on our observations, another affirming finding is the difference in TBARS level for determined lipid peroxidation-a process by which free radicals destroy lipids' carbon-carbon double bonds [7], which were elevated in the IR group and reduced in the C and IR-PRO groups. Our TBARS results align with those in the literature [27,28].…”

Section: Discussionsupporting

confidence: 93%

The Effect of “Proanthocyanidin” on Ischemia–Reperfusion Injury in Skeletal Muscles of Rats

Özer,

Koçak,

Sezen

et al. 2024

Medicina

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Background and Objectives: Lower limb skeletal muscle ischemia–reperfusion (IR) injury is associated with increased morbidity and mortality, and it is common in several clinical situations such as aortic aneurysms repairment, peripheral arterial surgery, vascular injury repairment, and shock. Although it is generally accepted that oxidative stress mediators have a significant role in IR injury, its precise mechanism is still unknown. Anecdotally, it is sustained not only by structural and functional changes in the organ it affects but also by damage to distant organs. The purpose of this report is to illustrate the effect of proanthocyanidin on IR injury. Materials and Methods: In our study, 18 male Wistar albino rats were used. The subjects were divided into three groups containing six mice each (control, C; ischemia–reperfusion, IR; ischemia–reperfusion and proanthocyanidin; IR-PRO). Intraperitoneal proanthocyanidin was given to the IR and proanthocyanidin groups 30 min before laparotomy, and 1 h ischemia led to these two groups. After one hour, reperfusion started. Muscle atrophy–hypertrophy, muscle degeneration–congestion, fragmentation–hyalinization, muscle oval-central nucleus ratio, leukocyte cell infiltration, catalase enzyme activity, and TBARS were all examined in lower-limb muscle samples after one hour of reperfusion. Results: When skeletal muscle samples were evaluated histopathologically, it was discovered that muscle atrophy–hypertrophy, muscle degeneration–congestion, fragmentation–hyalinization, and leukocyte cell infiltration with oval-central nucleus standardization were significantly higher in the IR group than in the C and IR-P groups. Oval-central nucleus standardization was significantly higher in the IR and IR-PRO groups than in the control group. TBARS levels were significantly higher in the IR group than in the control and IR-PRO groups, while catalase enzyme activity was found to be significantly lower in the IR group than in the control and IR-PRO groups. Conclusions: As a consequence of our research, we discovered that proanthocyanidins administered before IR have a protective impact on skeletal muscle in rats. Further research in this area is required.

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Section: Discussionsupporting

confidence: 93%

The Effect of “Proanthocyanidin” on Ischemia–Reperfusion Injury in Skeletal Muscles of Rats

Özer,

Koçak,

Sezen

et al. 2024

Medicina

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“…Ozturk et al studied role of NF-κB in ovarian IR. The authors found that, after IR, oxidative stress and inflammation were increased and these cellular events upregulated the expression of NF-κB in IR groups 20 . A similar study was done by Deniz et al In their ovarian IR injury model on animals, they found NF-κB expression was increased in ovarian tissues 21 .…”

Section: Discussionmentioning

confidence: 98%

E-cadherin and NF-κB expression in the vagina after ovarian ischemia and reperfusion

Yurci,

Zaman,

Sarı

et al. 2024

Acta Cir. Bras.

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Purpose: To investigate inflammation and cell adhesion molecules in the vagina after ovarian ischemia-reperfusion (IR) injury. Methods: 20 Wistar albino female rats were divided into two groups: control, and IR groups. In IR group, blood flow was restricted for 2 hours for ovarian ischemia. Then, tissues were re-blood 2 hours for reperfusion. Vagina tissues were excised and processed for histopathological analysis. Histopathological and biochemical follow-ups were performed. Results: Both malondialdehyde and myeloperoxidase values were increased in IR group compared to control group. Glutathione content was decreased in IR group compared to control group. Epithelial degeneration, inflammation, dilatation, and nuclear factor-κB (NF-κB) expression were increased in IR group compared to control group. E-cadherin expression was significantly decreased in IR group. In the IR group, E-cadherin showed a positive reaction in adenomas, gland-like cryptic structures, cellular junctions with clustered inflammatory cells. In the IR group, NF-κB expression was increased in basement membrane, inflammatory cells, in blood vessels. Conclusions: Ovarian ischemia caused degeneration of epithelial cells in the vaginal region and disruptions in the cell junction complex, which leads to activation of E-cadherin and NF-κB signaling pathway and alterations in reproductive and embryonal development in the vaginal region.

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New insights on pharmacological and therapeutic potentials of trimetazidine beyond anti-anginal drug: A comprehensive review

Singh,

Oladimeji-Salami,

Akindele

2024

European Journal of Pharmacology

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The protective effects of trimetazidine against ovary ischemia–reperfusion injury via the TLR4/Nf‐kB signal pathway

Cited by 6 publications

References 48 publications

The Effect of “Proanthocyanidin” on Ischemia–Reperfusion Injury in Skeletal Muscles of Rats

The Effect of “Proanthocyanidin” on Ischemia–Reperfusion Injury in Skeletal Muscles of Rats

E-cadherin and NF-κB expression in the vagina after ovarian ischemia and reperfusion

New insights on pharmacological and therapeutic potentials of trimetazidine beyond anti-anginal drug: A comprehensive review

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